nt13

NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.

NT 13 acetate is a partial agonist of NMDA receptor and can be used for research on depression, anxiety, and other related diseases.

(2E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one is also known as DMPVP.It is a novel synthetic compound belonging to the class of cathinones that is psychoactive.

Antiproliferative agent-13 is a compound with antiproliferative activity.

Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent.

Antibiofilm agent-13 (compound 14b) is an effective broad-spectrum antibacterial agent that functions by disrupting the integrity of bacterial cell membranes. It achieves this through the degradation of transmembrane potential and increased membrane permeability, which leads to the production of intracellular ROS and the leakage of DNA and proteins, ultimately resulting in bacterial death. Antibiofilm agent-13 effectively inhibits both Gram-positive bacteria (MIC ranging from 0.5-1 μg/mL) and Gram-negative bacteria (MIC ranging from 1-32 μg/mL).

Antituberculosis agent-13 (Compound 11) demonstrates antituberculosis activity, effectively inhibiting both wild-type and mutant strains of Mycobacterium tuberculosis, with an IC50 range of 4-62.5 nM. Additionally, Antituberculosis agent-13 exhibits anti-leukemia properties, inhibiting MOLM-13 with an IC50 of 3.8 μM.

Antifungalagent 131 (compound A20) is an antifungal agent with a minimum inhibitory concentration (MIC) of 64 μg/mL. When used in combination with Fluconazole, it demonstrates exceptional antifungal potential.

Antifungalagent 132 (compound 25) is a selective and potent antifungal agent. It inhibits Cryptococcus neoformans May1 with a Ki value of 180 pM.

Antifungalagent 130 (Compound A7) is an orally active antifungal agent exhibiting significant inhibitory activity against Candida glabrata [MIC= 0.12 ng/mL] and Cryptococcus neoformans [MIC= 0.12 ng/mL]. It effectively disrupts fungal cell iron homeostasis and induces oxidative stress, leading to antifungal effects. Additionally, Antifungalagent 130 inhibits the formation of fungal virulence factors, such as biofilms, capsules, urease, and melanin. This compound shows strong antifungal properties, making it suitable for research on drug-resistant fungal infections.

Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.

Antitumor agent-135 (Compound 13) is an effective anticancer drug that induces apoptosis. It exhibits IC50 values of 3.79, 10.55, 1.14, and 4.14 μM against NSCLC cell lines (A549, H460, PC-9, and PC-9/GR), respectively.

Antitumor agent-132 (Compound F9) is a compound with antitumor properties. It induces apoptosis, increases intracellular ROS, and decreases MMP.

Antitumor agent-139 (compound 9b) is a gold (I) complex targeting liver and mitochondria, capable of generating reactive oxygen species (ROS) and facilitating DNA excretion. It inhibits tumor growth in patient-derived liver cancer xenograft models.

Anti-MRSA agent 13 (Compound 9b) is an effective antimicrobial against methicillin-resistant Staphylococcus aureus (MRSA) with a minimal inhibitory concentration (MIC) of 0.5–2 μg/mL for clinically isolated strains. It exhibits excellent biocompatibility, stable plasma tolerance, and a low propensity for resistance. Anti-MRSA agent 13 disrupts the cell wall and membrane, reduces metabolic activity, induces oxidative damage, and impairs DNA function, leading to MRSA death through a multi-target synergistic mechanism.

Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.

Antifungalagent 133 (compound D2) is an orally active antifungal compound with an MIC80 value of 0.13 µg/mL against C. neoformans H99. It is suitable for research on cryptococcal meningitis.

Antifungalagent 135 (Compound C2) is an antifungal agent that functions as a succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.99 μM. It demonstrates potent antifungal efficacy against Valsa mali, Sclerotinia sclerotiorum, and Phytophthora capsici, with EC50 values of 0.280 mg/L, 1.11 mg/L, and 0.130 mg/L, respectively. This compound provides protective and therapeutic effects on P. capsici and V. mali by effectively disrupting mycelial structural integrity and inhibiting mycelial growth.

Antifungalagent 136 (Compound M-15) is an irreversible inhibitor of fungal lanosterol 14α-demethylase (CYP51). It exhibits potent antifungal activity against drug-resistant Candida albicans and can downregulate the expression of IL-6. Antifungalagent 136 shows promise for research into fungal infections and inflammatory diseases.

Neuroprotective agent 13 is a 1H-benzimidazole [d] class compound with neuroprotective properties that can penetrate the blood-brain barrier. It activates autophagy (autophagy) and mitigates the accumulation of SCMAS in induced pluripotent stem cell (iPSC) derived neural progenitor cells. Neuroprotective agent 13 is applicable in the study of neurological disorders such as neuronal ceroid lipofuscinoses (NCLs).

Antifungalagent 137 (Compound 4S) is an antifungal compound that inhibits Phomopsis sp. (PS) with an EC50 value of 0.15 μg/mL. It targets lanosterol 14α-demethylase (CYP51) with an IC50 value of 5.00 μg/mL. Additionally, it disrupts PS mycelial morphology, compromises cell membrane integrity, and increases intracellular ROS levels, inducing oxidative stress. This compound is useful for research on fungal infections.

Herbicidal agent 13 (Compound II-13) is a herbicide. It targets both PDS and ZDS, with dissociation constants (Kd) for SynPDS and AtZDS of 71.8 μM and 0.586 mM, respectively. Herbicidal agent 13 enhances ROS production and shows post-emergence herbicidal activity against dicotyledonous and monocotyledonous weeds POLFU.

Antifungalagent 139 (Compound li) is an antifungal agent that demonstrates antifungal activity against Colletotrichum gloeosporioides by inhibiting CgSfu1 and CgRidA. It completely inhibits the growth of hyphae, conidial germination, and appressorium formation, with an EC50 of 18 μg/mL. Antifungalagent 139 effectively blocks the infection of host plants, such as tulip trees and cedar, by the pathogen. This compound is valuable for studying anthracnose disease.

Anti-TNBC agent-13 is a NO donor-Aurovertin B conjugate that can induce ferroptosis. It inhibits GPX4 activity, leading to cell death in triple-negative breast cancer (TNBC) cells. Anti-TNBC agent-13 is useful for research in triple-negative breast cancer.