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Cat No. | Product Name | Synonyms | Targets |
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T9833 | Opiranserin hydrochloride | P2X Receptor , GlyT , 5-HT Receptor | |
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50... | |||
T6504 | Flupirtine maleate | Katadolon maleate | Potassium Channel , NMDAR , iGluR |
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener. | |||
TP1559L | Ziconotide Acetate (107452-89-1 free base) | Prialt,Ziconotide Acetate | Calcium Channel |
Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan... | |||
T16399 | Opiranserin | P2X Receptor , GlyT , 5-HT Receptor | |
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) an... | |||
T3720 | Tebanicline hydrochloride | ABT-594 hydrochloride,Ebanicline hydrochloride | AChR |
Tebanicline hydrochloride (Ebanicline hydrochloride) , is an effective synthetic nicotinic (non-opioid) analgesic drug. | |||
T39349 | Vocacapsaicin hydrochloride | CA-008 hydrochloride | TRP/TRPV Channel |
Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief. | |||
T0470 | Nefopam hydrochloride | Fenazoxine hydrochloride,Nefopam HCl | Wnt/beta-catenin , Sodium Channel |
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity. | |||
T39529 | AT-121 hydrochloride | Opioid Receptor | |
AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and a... | |||
T8414 | SNC 80 | Snc-80,SNC80,NIH 10815 | Opioid Receptor |
SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 show... | |||
T37610 | AT-121 | Opioid Receptor | |
AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing either μ-opioid receptors or neuropeptide receptors... | |||
T27253 | Elismetrep | ||
Elismetrep is a non-opioid analgesic. | |||
T23972 | DDD028 | DDD 028,DDD-028 | |
DDD-028 is a potential non-opioid and non-cannabinoid analgesic. It was used for treating neuropathic and inflammatory pain. | |||
T34784 | TAN67 | SB-205607 dihydrobromide,SB 205607 dihydrobromide,SB205607 dihydrobromide,TAN-67,TAN 67 | |
TAN67 is the first effective selective non-peptide delta1 opioid receptor. | |||
T31631 | Enkephalin-leu, ala(2)-ser(6)- | DALES,2-Ala-6-ser-leu-enkephalin | |
Enkephalin-leu, ala(2)-ser(6)- is an active compound at the delta (non-complexed) opioid receptor. | |||
T25690 | Levallorphan tartrate | Lorfan | |
Levallorphan tartrate is an opioid antagonist with properties similar to those of NALOXONE. Levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induce... | |||
T26475 | A-286501 | ||
A-286501 is an orally active adenosine kinase inhibitor (IC50=0.47 nM). A-286501 effectively attenuates nociception by a non-opioid, non-non-steroidal anti-inflammatory drug ADO, receptor mediated mechanism. | |||
T23313 | SB 205607 dihydrobromide | Others | |
non-peptide δ1 opioid receptor agonist | |||
T70503 | Exp 631 | ||
Exp 631 is a centrally-acting non-opioid analgesic; exhibits serotonin and norepinephrine reuptake inhibiting activities. | |||
T39747 | Nepinalone hydrochloride | ||
Nepinalone hydrochloride, a non-opioid antitussive, is an alchilaminate derivative of β-tetralone. This orally active compound effectively suppresses coughing. | |||
T39348 | Vocacapsaicin | CA-008,Vocacapsaicin | |
Vocacapsaicin (CA-008), a prodrug of Capsaicin and a first-in-class non-opioid TRPV1 agonist, offers significant and enduring pain relief. | |||
T69422 | Flupirtine HCl | ||
Flupirtine HCl is the salt form of Flupirtine, also known as W-2964, an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the n... | |||
T2806L | Lappaconitine HCl | Lappaconitine hydrochloride | |
Lappaconitine HCl is a centrally acting non-opioid analgesic and class-I antiarrhythmic. It acts by binding to the site-2 receptor and irreversibly blocking hH1 sodium channels. | |||
T68933 | Gaboxadol hydrobromide | ||
Gaboxadol hydrobromide is a GABA agonist. It is an inhibitor of GABA uptake systems. Gaboxadol can also be a non-opioid analgesic and a novel type of hypnotic. | |||
T12169 | Naltrindole hydrochloride | Opioid Receptor | |
Naltrindole hydrochloride is a selective and non-peptide δ opioid receptor antagonist(Ki = 0.02 nM). | |||
T71772 | Bicifadine free base | ||
Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less ... | |||
T27363 | FR 64822 | FR-64822,FR64822 | |
FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), a novel non-opioid antinociceptive compound, displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptiv... | |||
T38192 | Unifiram | Others | |
Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra... | |||
T60473 | Nepinalone | ||
Nepinalone is an alchilaminate derivative of β-tetralone. Nepinalone is an orally active cough suppressant that possesses a non-opioid antitussive activity [1]. | |||
T3694L | Tebanicline tosylate | ||
Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine. Like epibatidine, tebanicline showed potent ... | |||
T73631 | (Rac)-SNC80 | ||
(Rac)-SNC80, a racemate of SNC80 (NIH 10815), is a potent, highly selective non-peptide δ-opioid receptor agonist, characterized by a K_i of 1.78 nM and an IC_50 of 2.73 nM. Demonstrating antinociceptive, antihyperalgesi... | |||
T83709 | LIH383 TFA | Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2 | |
LIH383 is a peptide agonist specifically designed to activate the chemokine (C-X-C motif) receptor 7 (CXCR7), which functions both as a chemokine and an opioid peptide scavenger receptor. Demonstrating a high selectivity... |
Cat No. | Product Name | Synonyms | Targets |
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T2870 | Matrine | Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine | Mitophagy , Ferroptosis , Opioid Receptor , Autophagy |
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. | |||
T23306 | Salvinorin A | Opioid Receptor | |
Salvinorin A is a non-nitrogenous κ-opioid selective agonist. |