nik

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

NIK-12192 is an indole derivative and inhibitor of vacuolar-H(+)-ATPase.

B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM) and a chemical probe for treating liver inflammation and injury, protecting the liver from inflammation and injury caused by oxidative stress and toxins.

Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.

Ipidacrine (NIK‐247) (NIK‐247) is an Antidementia Agent

Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.

NIK ligand 1 (compound 2) is a ligand for the NF-κB-inducing kinase (NIK).

(S)-NIK SMI1 is the isomer of NIK SMI1 and can be used as a control compound in experiments. NIK SMI1 serves as a potent and selective inhibitor of NF-κB-inducing kinase (NIK), effectively blocking the NIK-catalyzed hydrolysis of ATP to ADP, with an IC50 of 0.23±0.17 nM.

NIK-250 is a P-glycoprotein inhibitor. NIK250 could reverse multidrug resistance in human glioma cells.

NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.

TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 μM. Additionally, TNIK-IN-3 demonstrates inhibitory activity against Flt4 (IC50 = 0.030 μM), Flt1 (IC50 = 0.191 μM), and DRAK1 (IC50 = 0.411 μM). This compound holds potential for carrying out research on colorectal cancer (CRC) [1].

TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.

TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.

Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overtreatments, before the advent of end

TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor with an IC50 of 1.27 nM. It effectively suppresses the production of pro-inflammatory cytokines and nitric oxide. In sepsis models, TNIK-IN-9 demonstrates significant anti-inflammatory effects, reduces mortality, and provides liver protection.

TNIK-IN-8 (Compound 35b) is a potent and orally active TNIK inhibitor with an IC50 of 6 nM, demonstrating antitumor properties.

Nikkomycin is used as an insecticide.

Nikkomycin J is used as an insecticide from Streptomyces tendae.

Nikkomycin M is used as an insecticide.

Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.

TNIK-IN-1 is an inhibitor of Traf2- and Nck-interacting kinase (TNIK).

Nikkomycin N is a bioactive chemical.

Nikkomycin pseudo-J is a nikkomycin isolated from Streptomyces tendae.

TNIK-IN-4, a powerful TNIK inhibitor, exhibits an IC50 value of 0.61 μM. Furthermore, it demonstrates inhibitory effects on the HCT116 cell line, which is representative of colorectal cancer [1].