neuromodulator

Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) is a biogenic monoamine structurally associated with noradrenaline. It can serve as a neurohormone, a neurotransmitter, and a neuromodulator in invertebrates.

Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain.

2-Phenylethylamine hydrochloride (benzeneethanamine hydrochloride) acts as neuromodulator in the central nervous system. It stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases as well as other enzymes.

3-Methoxytyramine (3-O-methyl Dopamine) is a cellular metabolite of dopamine (3-hydroxytyramine), a neuromodulator that induces behavioral effects, induces significant ERK and CREB phosphorylation, and is capable of inducing a complex set of aberrant involuntary movements in acutely depleted dopamine-containing mice.

Acamprosate, an orally active neuromodulator, is used to study and treat alcohol dependence and alcoholism. Acamprosate is an analog of amino acid neurotransmitters (e.g., taurine and homocysteic acid) that modulates NMDA receptor activity via binding to a spermidine-sensitive site. Research indicates Acamprosate acts as a 'partial co-agonist' at NMDA receptors.

Neurotensin TFA (39379-15-2 free base) is an endogenous 13 amino acid neuropeptide with profound opioid-independent analgesic effects. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders, and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems. It has a role as a human metabolite, a mitogen, a neurotransmitter and a vulnerary.

Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace amounts in the brains of mammals and is recognized to play a role as a neuro

17a-Hydroxypregnenolone, a pregnane steroid, is a prohormone involved in the synthesis of dehydroepiandrosterone (DHEA).

m-Tyramine has effects on the adrenergic and dopaminergic receptor.m-Tyramine is an endogenous trace amine neuromodulator.

N-Methylphenethylamine (NMPEA) hydrochloride is a potent TAAR1 agonist and also functions as a trace amine neuromodulator.

Arginylphenylalaninamide, an FMRamide fragment, may be utilized as a neurotransmitter or neuromodulator by optic lobe neurons of different types.

Carisbamate (RWJ-333369) is an orally active neuromodulator that suppresses the development and propagation of epileptiform discharges, confers neuroprotection following epilepticus-like injury in vitro, and demonstrates robust antiepileptic efficacy in genetic models of generalized and nonconvulsive epilepsy, supporting its translational relevance in epilepsy research.

Biotin-Substance P acts as a neurotransmitter and neuromodulator in the central nervous system. Neurokinin 1 receptor (NK1R) is the endogenous receptor of Biotin-Substance P.

Homocarnosine TFA, a unique dipeptide of γ-aminobutyric acid (GABA) and histidine found in the brain, acts as an inhibitory neuromodulator synthesized from GABA within neurons. It exhibits anticonvulsant effects [1], and possesses antioxidant and anti-inflammatory properties, prevents DNA damage, and inhibits the formation of advanced glycation end-products [2].

Substance P (7-11) acetate is a specific fragment of the neuropeptide Substance P, acting as a neurotransmitter and neuromodulator in the central nervous system, with its endogenous receptor being neurokinin 1 (NK1R), making it useful for neurophysiological and pharmacological research.

[Gly11] Substance P, an analog of Substance P itself, functions as a neuropeptide within the CNS, serving dual roles as both a neurotransmitter and neuromodulator [1].

[His11]Substance P, an analog of Substance P (Substance P), functions as both a neurotransmitter and neuromodulator in the central nervous system (CNS) [1].

[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is a synthetic analog of Substance P, a neuropeptide that functions as both a neurotransmitter and neuromodulator in the central nervous system (CNS).

Octopamine-D4 hydrochloride is the deuterated form of Octopamine hydrochloride. Octopamine ( (±)-p-Octopamine) hydrochloride is a bioamine structurally related to noradrenaline, functioning as a neurohormone, neuromodulator, and neurotransmitter in invertebrates. It stimulates Chinese hamster ovary cells transfected with human alpha2-adrenergic receptors (α2-ARs). Additionally, Octopamine hydrochloride (T0469) enhances glycogenolysis, glycolysis, oxygen consumption, gluconeogenesis, and portal perfusion pressure.

12-HETE-D8 is a deuterated form of 12-HETE. As the primary metabolite of arachidonic acid catalyzed by 12-LOX, 12-HETE (T35507) inhibits apoptosis. It facilitates NF-κB activation and nuclear translocation via the integrin-linked kinase (ILK) pathway. Additionally, 12-HETE (T35507) exhibits both antithrombotic and prothrombotic effects and serves as a neuromodulator.

Octopamine hydrochloride (Standard) is the standard substance of Octopamine hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) is a biogenic monoamine structurally associated with noradrenaline. It can serve as a neurohormone, a neurotransmitter, and a neuromodulator in invertebrates.

Tryptamine (Standard) is the standard substance of Tryptamine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace amounts in the brains of mammals and is recognized to play a role as a neurotransmitter or neuromodulator.

17a-Hydroxypregnenolone (Standard) is a reference standard for research and analysis in studies involving 17a-Hydroxypregnenolone. 17a-Hydroxypregnenolone is a progestational steroid, the hormone principle for the formation of dehydroepiandrosterone.17a-Hydroxypregnenolone is a neuromodulator.17a-Hydroxypregnenolone is a neuromodulator.

Nervonoyl ethanolamide (NEA), an endogenous cannabinoid, functions as both a presynaptic and postsynaptic neuromodulator. Additionally, it is utilized in inflammation research [1].