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Search Result

Search Results for " myeloperoxidase "

Targets

Glutathione Peroxidase

29

Compounds

5

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T26389 4-POBN NSC-640,NSC640,4-Aminobenzohydrazide,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH Glutathione Peroxidase
4-POBN (Myeloperoxidase Inhibitor 1) is a potent and irreversible inhibitor of myeloperoxidase (IC50 = 0.3 µM). 4-POBN can be used in studies about subacute stroke.
T5463 Verdiperstat AZD3241,AZD 3241 Glutathione Peroxidase
Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.
T4090 PF-06282999 Glutathione Peroxidase
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potentially useful for the treatment of cardiovascular diseases.
T5340 MPO-IN-28 Glutathione Peroxidase
MPO-IN-28 is a novel potent, irreversible Myeloperoxidase (MPO) inhibitor with IC50 of 44 nM.
T9416 Dansylglycine Others
Dansylglycine is a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase[1].
T14379 AZD5904 Glutathione Peroxidase
AZD5904 is a potent and irreversible human Myeloperoxidase (MPO) inhibitor(IC50 of 140 nM and has similar potency in mouse and rat).
T61028 Mitiperstat AZD4831 Glutathione Peroxidase
Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease.
T8223 Avacopan CCX168 Complement System
Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model o...
TP2334 PMX 53 acetate(219639-75-5 free base) Complement System
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an ag...
T38063 N-Acetyl lysyltyrosylcysteine amide Glutathione Peroxidase
N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO production in vivo. N-Ac...
T25510 HX1 HX 1,HX-1
HX1 is a potent reversible myeloperoxidase (MPO) inhibitor.
T69110 Aseanostatin P5
Aseanostatin P5 inhibits myeloperoxidase (MPO) release from human polymorphonuclear leukocytes.
T38914 MPO-IN-3
MPO-IN-3, a powerful inhibitor of myeloperoxidase (MPO), is described as such in example 191 of WO2013068875A1. MPO, a heme-containing enzyme, is classified under the peroxidase superfamily.
T69287 NAA-004
NAA-004, also known as APAZA, has been shown to significantly inhibit toxin A-induced myeloperoxidase activity, luminal fluid accumulation, and structural damage to the colon in instances of toxin A-induced colitis.
T61711 COX-2-IN-14
COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory ac...
T40137 MPO-IN-1
MPO-IN-1 is a powerful and orally bioavailable indole-containing inhibitor that acts irrevocably on myeloperoxidase (MPO). With IC50 values of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively, MPO-IN-...
T62347 MPO-IN-5
MPO-IN-5 is a potent, irreversible inhibitor of MPO (myeloperoxidase). MPO-IN-5 inhibits MPO peroxidation (IC50: 0.22 μM) and hERG binding (IC50: 2.8 μM). 23000 M 1s 1.
T38384 Nexinhib20
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony...
T38063L N-Acetyl lysyltyrosylcysteine amide acetate N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base) Glutathione Peroxidase
N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide acetate inhibits MPO-dependent hypochlorous acid (HOCl) genera...
T73659 HLF1-11
HLF1-11, derived from human lactoferrin, serves as a broad-spectrum antimicrobial agent. It not only inhibits human MPO (myeloperoxidase) activity but also influences GM-CSF (granulocyte-macrophage colony-stimulating fac...
T60281 MPO-IN-4
MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC 50 of 25 nM. MPO-IN-4 also demonstrates inhibition of thyroid peroxidase (TPO) with IC50 of 2.2 μM. MPO-IN-4 has no effect on me...
T37270 9(E),11(E)-12-nitro Conjugated Linoleic Acid
9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combinat...
T36235 5-Chlorouracil
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell...
T36221 2-chloro Palmitic Acid
2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic aci...
T36830 9-Nitrooleate
Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as p...
T83669 PMX-53 TFA AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53
PMX-53, a macrocyclic complement 5a (C5a) peptidomimetic and C5a receptor antagonist (IC50 = 0.3 µM), effectively inhibits the C5a-induced secretion of myeloperoxidase (MPO) in isolated human polymorphonuclear leukocytes...
T36418 O-Desmethyl-N-deschlorobenzoyl Indomethacin
O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-...
T36660 Olsalazine-13C6 Olsalazine-13C6
Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that...
T35881 Resolvin E2
Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-...

Compounds

4-POBN
T26389
Synonym: NSC-640,NSC640,4-Aminobenzohydrazide,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH
Target: Glutathione Peroxidase
Verdiperstat
T5463
Synonym: AZD3241,AZD 3241
Target: Glutathione Peroxidase
PF-06282999
T4090
Synonym:
Target: Glutathione Peroxidase
MPO-IN-28
T5340
Synonym:
Target: Glutathione Peroxidase
Dansylglycine
T9416
Synonym:
Target: Others
AZD5904
T14379
Synonym:
Target: Glutathione Peroxidase
Mitiperstat
T61028
Synonym: AZD4831
Target: Glutathione Peroxidase
Avacopan
T8223
Synonym: CCX168
Target: Complement System
PMX 53 acetate(219639-75-5 free base)
TP2334
Synonym:
Target: Complement System
N-Acetyl lysyltyrosylcysteine amide
T38063
Synonym:
Target: Glutathione Peroxidase
HX1
T25510
Synonym: HX 1,HX-1
Target:
Aseanostatin P5
T69110
Synonym:
Target:
MPO-IN-3
T38914
Synonym:
Target:
NAA-004
T69287
Synonym:
Target:
COX-2-IN-14
T61711
Synonym:
Target:
MPO-IN-1
T40137
Synonym:
Target:
MPO-IN-5
T62347
Synonym:
Target:
Nexinhib20
T38384
Synonym:
Target:
N-Acetyl lysyltyrosylcysteine amide acetate
T38063L
Synonym: N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)
Target: Glutathione Peroxidase
HLF1-11
T73659
Synonym:
Target:
MPO-IN-4
T60281
Synonym:
Target:
9(E),11(E)-12-nitro Conjugated Linoleic Acid
T37270
Synonym:
Target:
5-Chlorouracil
T36235
Synonym:
Target:
2-chloro Palmitic Acid
T36221
Synonym:
Target:
9-Nitrooleate
T36830
Synonym:
Target:
PMX-53 TFA
T83669
Synonym: AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53
Target:
O-Desmethyl-N-deschlorobenzoyl Indomethacin
T36418
Synonym:
Target:
Olsalazine-13C6
T36660
Synonym: Olsalazine-13C6
Target:
Resolvin E2
T35881
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T5280 3-Chloro-L-Tyrosine 3-Chlorotyrosine,Chlorotyrosine Others , Endogenous Metabolite
3-Chloro-L-Tyrosine (Chlorotyrosine), a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low-density lipoprotein isolated from human atherosclerotic intima. In particular, myeloperoxidase h...
TJS0338 4-Methylesculetin 4-Methyl-6,7-dihydroxycoumarin,Methylesculetin Antioxidant , Glutathione Peroxidase
4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
TN4303 Isokaempferide ATPase , Potassium Channel , Calcium Channel , TNF , Prostaglandin Receptor
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, m...
T75618 Sorbifolin
Sorbifolin, a flavone glucoside isolated from Pterogyne nitens, exhibits myeloperoxidase (MPO) inhibitory and radical scavenging activities. This compound functions as an effective MPO inhibitor, demonstrated by its IC 5...
T37770 Taurohyodeoxycholic acid
Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol ...

Natural Products

3-Chloro-L-Tyrosine
T5280
Synonym: 3-Chlorotyrosine,Chlorotyrosine
Target: Others, Endogenous Metabolite
4-Methylesculetin
TJS0338
Synonym: 4-Methyl-6,7-dihydroxycoumarin,Methylesculetin
Target: Antioxidant, Glutathione Peroxidase
Isokaempferide
TN4303
Synonym:
Target: ATPase, Potassium Channel, Calcium Channel, TNF, Prostaglandin Receptor
Sorbifolin
T75618
Synonym:
Target:
Taurohyodeoxycholic acid
T37770
Synonym:
Target:

Recombinant Proteins

Species：
Human (1)
Mouse (1)
Expression System：
HEK293 Cells (2)
Tag：
C-10xHis (1)
C-His (1)
Cat No. Product Name Species Expression System
TMPY-05252 Myeloperoxidase/MPO Protein, Human, Recombinant (His) Human HEK293 Cells
MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important en...
TMPJ-00833 MPO Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride,...
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