morphogenesis

Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.

MGCD-265 analog (Glesatinib) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively.

Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.

AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator.

MreB Perturbing Compound A22 hydrochloride is an effective inhibitor of MreB, a bacterial actin-like protein. It disrupts cell wall assembly and causes morphological changes, used for bacterial morphogenesis and antibiotic research.

CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids.

IHVR-11029 is a potent inhibitor of ER α-glucosidase. IHVR-11029 is active against multiple hemorrhagic fever viruses and efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses.

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W140 in supplemental material). It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

TCSA is an inhibitor of fungal morphogenesis, biofilm formation, and host cell invasion.

Fusarisetin A, a pentacyclic fungal metabolite, acts as an acinar morphogenesis inhibitor.

GRGESP, a collagen gel contraction inhibitor, impedes human fibroblast spreading within collagen gels and significantly reduces gel contraction, making it a valuable agent for research in connective tissue morphogenesis [1].

Mutanocyclin, as a potent antifungal agent, can inhibit the filamentation of Candida albicans and downregulate the mRNA expression levels of HWP1, ECE1, FLO8 and TEC1 genes. In addition, Mutanocyclin can also effectively inhibit yeast morphogenesis in an in vitro mouse model.

Anti-DDR1/CD167a Antibody is a neutralizing monoclonal antibody targeting the receptor tyrosine kinase DDR1, acting by blocking its interaction with extracellular matrix collagen. The compound is an essential tool for investigating how cell-matrix interactions regulate stem cell fate and tissue morphogenesis, aiming to reveal the molecular logic of multi-lineage differentiation and organ regeneration by intervening in the DDR1 signaling axis.