juvenile

Juvenile hormone B 3 (Juvenile hormone III bisepoxide) (mixture of diastereomers) is a sesquiterpenoid hormone. It can be isolated from the corpora allata (CA) of higher dipteran insects such as fruit flies and Drosophila melanogaster. This hormone exhibits anti-metamorphic activity and induces the expression of Kr-h1 by directly interacting with juvenile hormone (JH) receptors (Met and Gce). Juvenile hormone B 3 (mixture of diastereomers) is applicable in insect lethality studies.

Methoprene (ZR-515) is a juvenile hormone (JH) mimic and a biological pesticide. Methoprene acts as an insect growth regulator interfering with the lifecycles of insects and preventing insects from reaching maturity or reproducing.

(Rac)-Juvenile hormone III, derived from farnesoic acid, represents the most prevalent homologue of juvenile hormones [1].

FMC 23509 is a bioactive chemical.

Pyriproxyfen (S-31183) is an insecticide that acts as a biomimetic of juvenile hormone.

LG100268 is a potent, selective, and orally active retinoid X receptor (RXR) agonist that agonizes RXR-α, RXR-β, and RXR-γ at the nanomolar level, selectively exceeding the RAR by three orders of magnitude.LG100268 is capable of inducing transcriptional activation in adipocytes; affecting the RXRs and their chaperone receptor, Foxl2/Dmrt1, to induce flounder masculinization in juvenile flounder; inhibits keratin 17 expression in nigrostriatal epithelial cells; and increases PD-L1 expression in HER2 or triple-negative breast cancer.

S-Methoprene (ZR2458) is an analog of juvenile hormone and can be used as an insecticide. S-Methoprene alters redox activity of cytochrome oxidase and induces male sex differentiation.

(E/Z)-Droloxifene is a mixture comprising (E)-Droloxifene, known as a selective estrogen receptor modulator, and (Z)-Droloxifene. (E)-Droloxifene binds to estrogen receptors (ER) in rabbit uterine homogenate with an IC50 of 24 nM. It increases uterine weight in immature rats and reduces the uterine weight increase caused by estradiol in juvenile rats. Additionally, (E)-Droloxifene inhibits the growth of human breast cancer cells MCF-7, ZR-75-1, and T47D stimulated by 17β-estradiol. In contrast, (Z)-Droloxifene shows weak binding to ER and exhibits neither estrogenic nor anti-estrogenic activity.

Precocene II (Ageratochromene), an antiallotropin compound, inhibits juvenile hormone biosynthesis. Precocene II has insecticidal, antifungal, antibacterial, and antioxidant activities.

Farnesane (2,6,10-Trimethyldodecane; Hemisqualane) is an isoprene derivative used to modulate juvenile hormone activity in insects.

IWP 12 is a highly efficient Porcupine (Porcn) inhibitor that inhibits the Wnt signaling pathway, blocking tail fin regeneration in both adult and juvenile fish.

AI 3-34137 is a juvenile hormone analog.

Cyclopren can be used as a juvenile hormone.

Juvabione is the methyl ester of todomatuic acid, both of which are sesquiterpenes (C15) found in the wood of true firs of the genus Abies. They exist as part of a mixture of sesquiterpenes based on the bisabolane scaffold. Sesquiterpenes of this family,

Juvocimene I and II isolated from the essential oil of sweet basil,Ocimum basilicum L are potent juvenile hormone mimics.

Juvocimene I and II are isolated from the essential oil of sweet basil,Ocimum basilicum L are effective juvenile hormone mimics.

C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]

TFM is a piscicide.1It is toxic to sea lamprey (P. marinus) with LC50values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. TFM (50 μM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively.2Formulations containing TFM have been used as lampricides in the control of larval sea lamprey populations. 1.Boogaard, M.A., Bills, T.D., and Johnson, D.A.Acute toxicity of TFM and a TFM/niclosamide mixture to selected species of fish, including lake sturgeon (Acipenser fulvescens) and mudpuppies (Necturus maculosus), in laboratory and field exposuresJ. Great Lakes Res.29(Suppl 1)529-541(2003) 2.Birceanu, O., McClelland, G.B., Wang, Y.S., et al.The lampricide 3-trifluoromethyl-4-nitrophenol (TFM) uncouples mitochondrial oxidative phosphorylation in both sea lamprey (Petromyzon marinus) and TFM-tolerant rainbow trout (Oncorhynchus mykiss)Comp. Biochem. Physiol. C. Toxicol. Pharmacol.153(3)342-349(2011)

Glycerol is an important component of triglycerides (fats and oils) and phospholipids. It is widely used in the food industry as a sweetener, humectant, and in pharmaceutical formulations. Additionally, glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis and can be employed to induce acute kidney injury models.

Gepotidacin hydrochloride, also known as GSK-2140944 hydrochloride, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin hydrochloride is a novel antibacterial drug candidate. Gepotidacin hydrochloride Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin hydrochloride is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, Gepotidacin hydrochloride inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

Asfotase alfa (ENB-0040), a bone-targeted genetically engineered glycoprotein, enhances survival, bone mineralization, and growth while preventing mineralization defects in the feet, rib cage, lower limbs, and jaws of Akp2 −/− knockout mice. It has applications in researching perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) [1].

Type A Allatostatin III (allatostatin 3), a neuropeptide capable of crossing the blood-brain barrier and exhibiting reversibility, suppresses hormone production in juvenile female cockroaches, with applications in pesticide research [1].

Methoprene (Standard) is the standard substance of Methoprene, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Methoprene (ZR-515) is a juvenile hormone (JH) mimic and a biological pesticide. Methoprene acts as an insect growth regulator interfering with the lifecycles of insects and preventing insects from reaching maturity or reproducing.

Thymic factor X (TFX-Jelfa) is an aqueous extract derived from the thymus of a juvenile calf and serves as a natural stimulator of lymphocyte function.