endonuclease-1

Cap-dependent endonuclease-IN-1 is a highly potent, orally active cap-dependent endonuclease inhibitor with antiviral activity for studying influenza virus infection.

pUL89 Endonuclease-IN-1 (Compound 13d), with an IC50 of 0.88 μM, is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease, demonstrating significant antiviral activity [1].

Compound 23, also known as PAN endonuclease-IN-1, demonstrates potent inhibitory activity against PAN endonuclease, a vital element of the influenza virus replication machinery and a significant antiviral target [1]. It exhibits dissociation constants (Kd) of 277 μM, 384 μM, and 328 μM for the wild type (WT), I38T, and E23K variants of PAN endonuclease respectively.

APE1-IN-1 is a potent inhibitor of purine pyrimidine endonuclease 1 (APE1) that crosses the blood-brain barrier, exhibits potential antitumor activity, and enhances the cytotoxicity of the alkylating agent [methyl methanesulfonate] on cancer cells.

FEN1-IN-1 (LNT-1) is an inhibitor of flap endonuclease 1 (FEN1). FEN1-IN-1 binds to the active site of FEN1. It partly achieves inhibition by the co-ordination of Mg2+ ions.

It is an inhibitor of the Human Apurinic apyrimidinic Endonuclease 1 (APE1)

FEN1-IN-3 is a human flap endonuclease-1 ( hFEN1 ) inhibitor that stabilizes hFEN1 with an EC 50 of 6.8 μM .

Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding(KD: 10 nM).

FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair.

Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).

Influenza virus-IN-1 (compound 14) is a potent inhibitor of influenza A virus, demonstrating anti-influenza A virus activities with a CC50 of >200 μM and an EC50 of 2.46 μM. It exhibits concentration-dependent inhibition activity for PAN endonuclease with an EC50 of 312.36 nM [1].

Influenza virus-IN-2 (compound 19) is a potent inhibitor of influenza A virus with anti-influenza activities, exhibiting a CC50 of 150.85 μM and an EC50 of 2.58 μM. Concentration-dependently, Influenza virus-IN-2 inhibits the PAN endonuclease with an EC50 of 489.39 nM [1].

ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1].

Cap-dependent endonuclease-IN-26, a potent inhibitor of cap-dependent endonuclease (CEN) with an IC50 of 286 nM, exhibits significant antiviral activity against a broad spectrum of influenza A and B strains [1].

pUL89 Endonuclease-IN-2 (Compound 15k) is a highly effective inhibitor of the pUL89 endonuclease of human cytomegalovirus (HCMV), demonstrating potent antiviral activities with an IC50 of 3.0 μM [1].

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

JFD00950 is a human flap endonuclease 1 (FEN1) inhibitor with in vitro inhibition of flap cleavage activity as well as cytotoxic activity against a colon cancer cell line, DLD-1.

NSC-13755 is a human flap endonuclease 1 (FEN1) inhibitor.

Cap-dependent endonuclease-IN-9 is a potent cap-dependent endonuclease (CEN) inhibitor with notable efficacy against the influenza virus, minimal cytotoxicity, enhanced in vivo pharmacokinetics, and robust pharmacodynamics. It effectively suppresses the RNA polymerase activity of Influenza A virus[1].

Influenza virus-IN-6 (Compound 35) is a potent inhibitor of the N-terminal domain of the polymerase acidic protein (PA N) endonuclease subunit of the influenza virus, with an inhibitory concentration 50 (IC 50) value of 0.20 μM [1].

APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic apyrimidinic endonuclease 1 (APE1). Exhibiting anticancer properties, APE1-IN-2 prompts the intracellular accumulation of platinum and initiates the activation of DNA damage response and apoptosis pathways [1].

Ribonuclease T1 (Rnase T1), widely utilized in biochemical research, is an endonuclease targeting single-stranded RNA. It cleaves the phosphodiester bond between 3'-guanosine residues and adjacent nucleoside 5'-OH groups, thereby producing 3'-GMP terminal oligonucleotides, and forms nucleoside 2', 3'-cyclic phosphoric acid intermediates in the process [1].

Cap-dependent Endonuclease-IN-12 (EXP-35) is a potent inhibitor of Cap-dependent endonuclease, demonstrating low cytotoxicity. This compound exhibits inhibitory effects on H1N1 [1].

Cap-dependent endonuclease-IN-22 is a potent inhibitor of cap-dependent endonuclease (CEN) [1].