cu/zn-superoxide

Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases

Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis.Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases

Cu/Zn Superoxide dismutase (Cu/ZnSOD; SOD1) is a cytoplasmic copper-zinc dimeric form of superoxide dismutase. It functions by catalyzing the dismutation of superoxide radicals.

AKV-9 is a mutant Cu/Zn superoxide dismutase (SOD1) inhibitor that effectively suppresses SOD1-induced protein aggregation and demonstrates significant protective effects against SOD1-induced cytotoxicity in PC-12 cells, with an EC50 of 0.3 μM. AKV-9 also ameliorates amyotrophic lateral sclerosis (ALS)-related phenotypes and significantly prolongs survival in mouse models, making it suitable for ALS pathogenesis and targeted therapy research.

CuATSM is a cell-permeable copper complex and PET tracer for selective hypoxia imaging. It also exhibits neuroprotective potential in ALS and Parkinson's disease by mitigating oxidative damage.

SOD1 (147-153) human, a peptide segment within Cu/Zn superoxide dismutase (SOD1), exhibits a high propensity for forming amyloid fibrils. This segment is involved in the formation of aggregates and serves as a common molecular determinant in both familial amyotrophic lateral sclerosis (fALS) and sporadic amyotrophic lateral sclerosis (sALS).