clone

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, demonstrating greater selectivity for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). It does not increase global histone H4 acetylation or reduce total intracellular HDAC activity but can induce tubulin acetylation[1][2].

Anti-Human MSLN Antibody (Clone HN1) is a humanised monoclonal antibody targeting MSLN (Mesothelin), composed of the mesothelin-specific HN1, which blocks the interaction between MSLN and CA125 with cancer cells, and can be used for cancer research.

C-Fos Lentiviral CDNA ORF Clone, Human, C-GFPSpark Tag is an ORF clone of the FOS plasmid, where Fos encodes a leucine zipper protein and forms the transcription factor complex AP-1, which regulates cell proliferation, differentiation, and transformation.

Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.

Suriclone (RP 31264) is a selective cyclic pyrrolidone analog with sedative and anxiolytic activity, but not significant sedative effects.Suriclone shows its effects by modulating GABA-A receptors.

Compound PDK0219, with CAS No. 43200-81-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0219 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Gestaclone is a progesterone receptor agonist, designed specifically for the activation of these receptors.

Suproclone, a member of the cyclopyrrolone compound class, functions as a sedative and anxiolytic. Its mechanism of action involves the modulation of GABAA receptors to achieve its calming and anti-anxiety effects.

Pimeclone hydrochloride is a psychostimulant or a respiratory stimulant drug.

2, 3-Dichloro-1, 4-naphthoquinone is an inhibitor of Itch, a HECT domain-E3 ligase. It is also used in pesticide formulations.

Cycloneroside E is a sesquiterpene aminoglycoside compound isolated from Trichoderma sp. SCSIOW21. It exhibits activity in inhibiting NO production, with an IC50 value of 48.0 µM in macrophage RAW 264.7 cells. Cycloneroside E can be used in anti-inflammatory research.

Cycloneroside B is a novel sesquiterpene aminoglycoside compound discovered in Trichoderma sp. SCSIOW21. It exhibits activity in inhibiting nitric oxide (NO) production, with an IC50 value of 50.7 µM for NO suppression. Cycloneroside B may be utilized in research related to inflammation.

Cycloneroside A is a sesquiterpene aminoglycoside compound identified from Trichoderma sp. SCSIOW21. It exhibits activity in inhibiting nitric oxide (NO) production, with an IC50 value of approximately 100 µM in RAW 264.7 macrophage cells. Cycloneroside A is applicable in anti-inflammatory research.

Cycloneroside C is a novel sesquiterpene aminoglycoside compound discovered in the deep-sea sediment fungus Trichoderma sp. SCSIOW21. This compound exhibits activity in inhibiting NO production, with an IC50 value of 57.1 μM in macrophage RAW 264.7 cell assays. Cycloneroside C can be utilized for research in the field of anti-inflammatory studies.

Cycloneroside D, a novel sesquiterpene aminoglycoside, was isolated from the deep-sea sediment fungus Trichoderma sp. SCSIOW21. It demonstrates activity in inhibiting NO production, with an IC50 value of 42.0 μM in macrophage RAW 264.7 cell experiments. Cycloneroside D is a potential candidate for anti-inflammatory research.

Stemazole is a novel small molecule human stem/progenitor cell proliferation activator that promotes the survival of human embryonic stem cells and maintains stemness, and promotes the survival of oligodendrocyte precursor cells in vitro. Stemazole significantly increased cell survival and clone formation in a dose-dependent manner, reduced apoptosis, and promoted recovery of motor dysfunction and myelin repair. Stemazole can be used as a therapeutic agent in demyelinating disorders, promoting OPC survival in vitro and regeneration in vivo.

GLP-1 receptor agonist 3 is a GLP-1 receptor agonist,Example 4A-1, has EC50s of 1.1 nM and 13 nM in Clone H6 and Clone C6 cell lines assay, respectively.

EA25 has been identified in the clone library of the bacterial 16S rRNA gene sequence.

PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.

Neuraminidase-IN-15 is an inhibitor of neuraminidase, effectively suppressing the activity of La Sota Clone 30 NDV-HN with an IC50 value of 0.06 µM. Neuraminidase-IN-15 is applicable for studies on Newcastle disease virus (NDV).

Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) stained splenic CD8+ T cells from NOD or 8.3-TCRαβ transgenic NOD mice.

Integrase-LEDGF/p75 allosteric inhibitor 1 is an orally active inhibitor that targets integrase-LEDGF/p75 (IN-LEDGF/p75), impeding HIV-1 DNA integration and exhibiting antiviral effects against the HIV-1 recombinant molecular clone NL432 with an EC50 of 3.9 nM.

GLP-1R agonist 9 acts as a GLP-1R agonist, demonstrating efficacy with EC50 values of 1.1 nM and 11 nM against CHO GLP-1R Clone H6 and Clone C6, respectively.

Elsilimomab (B-E8) is a monoclonal antibody targeting interleukin-6 (IL-6), inhibiting DNMT3A mutant clone-induced hematopoietic stromal cell senescence, used in the study of multiple myeloma and renal cell carcinoma.