cap 3

CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 μM.

1,2-Dipalmitoyl-sn-glycero-3-PE-N- (cap biotin) (sodium salt)can be used to construct lipid vesicles and form lipid bilayer (SLB). 1,2-Dipalmitoyl-sn-glycero-3-PE-N- (cap biotin) (sodium salt)as a biotinylated phospholipid can be used to study the interaction between protein and lipid-binding ligands.

Cap-dependent endonuclease-IN-3 is a potent inhibitor of cap-dependent nucleic acid endonucleases (CEN), demonstrating potential for investigating influenza A and B infections.

CAPm7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU is a monomeric material utilized in nucleotide synthesis.

CAP 37 (20-44), a peptide derived from amino acid residues 20 to 44 of CAP37, embodies a segment of the cationic antimicrobial protein of 37 kDa. This multifunctional protein plays significant roles as indicated in its description [1].

Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.

Rabdosin C is an ent-kaurane diterpenoid natural product that can be isolated and extracted from Isodon rubescens var. lushanensis. Existing studies confirm that Rabdosin C exhibits certain cytotoxic activity.

Anti-PACAP38 Antibody represents a highly specialized monoclonal antibody specifically engineered to target the human pituitary adenylate cyclase-activating polypeptide 38 isoform with exceptional binding affinity and selectivity, effectively facilitating the measurable neutralization of ligand-mediated signaling within the GPCR/G Protein pathway to evaluate its functional role in neurovascular regulation during strictly monitored laboratory observation periods and functional cyclic AMP accumulation assays to ensure high experimental sensitivity.

PACAP-38 (31-38), human, mouse, rat (TFA), exhibits potent, efficacious, and sustained stimulatory effects on sympathetic neurons.

PACAP-38 (31-38), [human, mouse, rat], exhibits potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production.

PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production and can

PACAP-38 (16-38), human, mouse, rat, exhibits potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production.

MYC-IN-4 is a MYC inhibitor that disrupts the interaction between MYC/MAX proteins with an IC50 of 3.06 μM. It inhibits MYC-aberrant PC-3 prostate cancer cells, exhibiting an IC50 of 0.440 μM. In FVB mice with Myc-CaP prostate tumor xenografts, MYC-IN-4 demonstrates significant antitumor efficacy. This compound is useful for prostate cancer research.

3'-O-Bn-GTP (3'-O-Benzyl-5'-O-guanosine triphosphate) sodium (CAP-164) is an analog of GTP. This compound demonstrates increased stability against esterases.

2',3'-O-Isopropylideneguanosine is an alkylated guanosine building block.1,2It has been used in the synthesis of ordered honeycomb microporous films and mRNA cap analogs. 1.Gao, Y.-F., Huang, Y.-J., Xu, S.-Y., et al.Ordered honeycomb microporous films from self-assembly of alkylated guanosine derivativesLangmuir27(6)2958-2964(2011) 2.Kore, A.R., Shanmugasundaram, M., and Vlassov, A.V.Synthesis and application of a new 2',3'-isopropylidene guanosine substituted cap analogBioorg. Med. Chem. Lett.18(17)4828-4832(2008)

eIF4E-IN-3 is a small-molecule inhibitor targeting eIF4E that disrupts cap-dependent mRNA translation initiation. By inhibiting eIF4E function, eIF4E-IN-3 modulates translation of specific proteins and has potential applications in mechanistic studies of eIF4E-dependent diseases such as cancer.

3'Ome-m7GpppAmpG, a trinucleotide cap analogue with a locked nucleic acid (LNA) molecule, demonstrates notable translational efficiency. It serves as a promising tool in molecular biology, applicable in mRNA vaccines and transfection processes, including protein production, gene therapy, and anti-cancer immunization [1].

3'Ome-m7GpppAmpG ammonium, a trinucleotide Cap analogue with a locked nucleic acid (LNA) component, demonstrates substantial translational efficiency. It emerges as a promising tool in molecular biology, applicable in mRNA vaccines and transfection processes including protein production, gene therapy, and anti-cancer immunization [1].

M7G(3'-OMe-5')pppA(2'-OMe) is an analogue used for mRNA cap synthesis in vitro.

3'-O-Me-m7G(5')ppp(5')A (ARCAcap) solution (100mM) is an anti-reverse cap analog (ARCA) with a unique RNA cap structure. This RNA cap structure is a common feature of mRNA in certain RNA viruses and eukaryotes, serving as a signal for the initiation of translation.