antimicrobial activity

Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.

LL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

Dermaseptin acetate, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration[1].

SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.

rCRAMP (rat) acetate, a cathelin-related antimicrobial peptide, exhibits antibacterial activity in rat brain peptide/protein extracts.

Magainin 1 acetate is an antimicrobial peptide. Magainin 1 acetate exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.

Alamethicin is a channel-forming antibiotic peptide isolated from Trichoderma viride with potential antimicrobial activity, inhibits methanogenesis and promotes acetogenesis in bioelectrochemical systems. alpha-Amanitin (BI-9627) is a channel-forming antibiotic peptide isolated from Trichoderma viride.

Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.

Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.

P-113 is a peptide with antimicrobial activity.

β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but not of resistantM. tuberculosisRM22 when used at a concentration of 128 μg/ml.3,4It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 μM, respectively).5Overexpression of β-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.6 1.Lehrer, R.I.Primate defensinsNat. Rev. Microbiol.2(9)727-738(2004) 2.Schroeder, B.O., Ehmann, D., Precht, J.C., et al.Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptideMucosal Immunol.8(3)661-671(2015) 3.Ouhara, K., Komatsuzawa, H., Yamada, S., et al.Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cellsJ. Antimicrob. Chemother.55(6)888-896(2005) 4.Fattorini, L., Gennaro, R., Zanetti, M., et al.In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosisPeptides25(7)1075-1077(2004) 5.Feng, J., Xie, Z., Yang, W., et al.Human beta-defensin 1, a new animal toxin-like blocker of potassium channelToxicon113(2016) 6.Han, Q., Wang, R., Sun, C., et al.Human beta-defensin-1 suppresses tumor migration and invasion and is an independent predictor for survival of oral squamous cell carcinoma patientsPLoS One9(3)e91867(2014)

Lactoferricin B (4-14), bovine (TFA), is a peptide derived from residues 4-14 of bovine lactoferrin, exhibiting broad-spectrum antimicrobial activity against various microorganisms[1].

CAP18 (rabbit) is a 37-amino-acid antimicrobial peptide derived from rabbit granulocytes, exhibiting extensive antimicrobial activity against both Gram-positive [IC50, 130-200 nM] and Gram-negative bacteria [IC50, 20-100 nM]. CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research.

Temporin L, a potent antimicrobial peptide, exhibits activity against Gram-negative bacteria and yeast strains, as well as demonstrating antiendotoxin properties.

Omiganan is a cationic antimicrobial peptide with activity against both gram-positive and gram-negative bacteria, as well as Candida spp. isolates. This compound, serving as an analogue of indolicidin, is utilized for research purposes related to alcohol nose and acne.

Poly-L-lysine hydrochloride plays a key role in promoting cell attachment to solid substrates by enhancing the electrostatic interaction between the negatively charged ions present on the cell membrane and the surface of the culture substrate as a non-specific attachment factor.Poly-L-lysine hydrochloride is a peptide that at low concentrations Due to its cationic peptide nature, Poly-L-lysine hydrochloride is antimicrobially active. These properties make it an important component for enhancing cell adhesion, regulating phase separation kinetics and demonstrating antimicrobial activity.

rCRAMP (rat), the rat cathelin-related antimicrobial peptide, plays a crucial role in the antibacterial activity found in rat brain peptide/protein extracts. As a potential key player in the innate immune system of the rat central nervous system, rCRAMP (rat) serves to enhance immune response.

Human β-defensin-1 (HβD-1) is a cysteine-rich, cationic skin antimicrobial peptide (SAP) produced by epithelial surfaces, circulatory cells, and cells of the reproductive tract, exhibiting antimicrobial activity against a broad spectrum of sperm-related bacteria.

IDR-1 is an antimicrobial peptide active against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.

Defensin HNP-1, human acetate is an antimicrobial peptide and human α -defensin found mainly in neutrophils with broad-spectrum antimicrobial activity against bacteria and viruses, triggers NF-κB and IRF1 thereby increasing IFN-α, induces apoptosis in tumor cells, inhibits vascular endothelial cell function, mediates immunity to infections and more.

Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic with antimicrobial activity that inhibits neuraminidase N1 of influenza A virus.

HLF1-11, derived from human lactoferrin, serves as a broad-spectrum antimicrobial agent. It not only inhibits human MPO (myeloperoxidase) activity but also influences GM-CSF (granulocyte-macrophage colony-stimulating factor)-driven monocyte differentiation into macrophages, thereby augmenting immune responses [1] [2].

Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, serves as a highly potent, specific antibiotic with remarkable antimicrobial activity against P. aeruginosa, demonstrated by MIC 50 and MIC 90 values of 0.12 mg/L. It uniquely targets the lipopolysaccharide transport protein D, showing potential for research on bacterial resistance [1] [2].

Beta-defensin 1, pig, is an antimicrobial peptide predominantly located in the tongue mucosa of pigs. It exhibits activity against a variety of bacteria including Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, Bordetella pertussis, and the fungus Candida albicans [1] [2].