acylase

ML318 is a biaryl nitrile PvdQ acylase inhibitor (IC50 of 20 nM for binding in the acyl-binding site). ML318 inhibits P. aeruginosa (PAO1) with IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting

AMG 118 Immobilized cephalosporin C acylase is an enzyme in immobilized form used primarily in industrial catalysis for the production of the vital pharmaceutical intermediate, 7-aminocephalosporanic acid (7-ACA). The CPC acylase it contains is a highly specialized β-lactam acylase or peptidase capable of cleaving the amide bond within β-lactams.

Aminoacylase (Acylase I) is a biochemical reagent used as a biomaterial or organic compound in life science research.

Sphingolipid ceramide N-deacylase (SCDase) is an enzyme that catalyzes the cleavage of the N-acyl linkage between fatty acids and sphingosine bases in various glycosphingolipids, converting them into lysoglycosphingolipids [1].

FR179642 is the cyclic peptide nucleus of the lipopeptide antifungal FR901379 and an intermediate in the synthesis of the echinocandin antifungal FK463 .1,2 1.Tomishima, M., Ohki, H., Yamada, A., et al.FK463, a novel water-soluble echinocandin lipopeptide: Synthesis and antifungal activityJ. Antibiot. (Tokyo)52(7)674-676(1999) 2.Ueda, S., Shibata, T., Ito, K., et al.Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907J. Antibiot. (Tokyo)64(2)169-175(2011)

Penicillin amidase (Penicillin acylase) is an enzyme utilized for cleaving the acyl side chains from penicillins. It facilitates the production of 6-aminopenicillanic acid and is also employed in resolving racemic mixtures, peptide synthesis, and the creation of semi-synthetic β-lactam antibiotics [1] [2] [3].

AMK-GX (Immobilized Penicillin G acylase) is a stabilized form of penicillin acylase with enhanced temperature and pH resistance. It exhibits high recovery rates and maintains most of its original activity even after 12 cycles of use. AMK-GX catalyzes the conversion of Penicillin G (PG) into 6-aminopenicillanic acid (6-APA) and 7-amino-desacetoxycephalosporanic acid, which are crucial intermediates in the production of β-lactam antibiotics.

AMK318 (Immobilized cephalexin acylase) is a biocatalyst and a critical enzyme in novel biocatalyst technology. Enzyme engineering focuses on improving enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions (such as low or high pH). By incorporating stimulus responsiveness into these enzyme modifications, dynamic control of activity becomes feasible.

AMK218 (Immobilized amoxicillin acylase) serves as a biocatalyst and is a key enzyme in new biocatalyst technologies. Enzyme engineering focuses on improving enzyme reaction kinetics, substrate selectivity, and activity under extreme conditions (e.g., low or high pH). Modifications that introduce stimulus responsiveness enable dynamic control of their activity.

AMK518 (Immobilized cefradine acylase) is an important biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on improving reaction kinetics, substrate selectivity, and activity under challenging conditions, such as low or high pH. By incorporating stimulus responsiveness into these enzyme modifications, dynamic control of activity is also achievable.

AMK328 (Immobilized cefaclor acylase) is a biocatalyst and a crucial enzyme in advanced biocatalyst technology. Enzyme engineering focuses on improving reaction kinetics, substrate specificity, and activity under extreme conditions such as low or high pH. Introducing stimulus responsiveness to these enzyme modifications enables dynamic control of their activity.

AMK618 (Immobilized cefadroxil acylase) is a biocatalyst and a key enzyme in innovative biocatalysis technology. Enzyme engineering focuses on improving enzyme reaction kinetics, substrate selectivity, and activity under extreme conditions (such as low or high pH). Introducing stimulus responsiveness to these enzyme modifications enables dynamic control of their activity.