t-channels — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10024	1-Octanol	Octanol	Calcium Channel , Endogenous Metabolite
	1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized ...		Calcium Channel , Endogenous Metabolite
T13059	T16Ainh-A01		Chloride channel
	T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated chloride channel (CaCC).		Chloride channel
T8944	TTA-A2		Calcium Channel
	TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ...		Calcium Channel
T0283	Trimethadione	3,5,5,-Trimethyloxazolidine-2,4-dione	Calcium Channel
	Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity.		Calcium Channel
T1814	ICILIN	AG-3-5	TRP/TRPV Channel
	ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.		TRP/TRPV Channel
T8867	RO2959 Hydrochloride	RO2959 HCl	IL Receptor , Calcium Channel , Interleukin
	RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.		IL Receptor , Calcium Channel , Interleukin
T5632	Suvecaltamide	MK-8998	Calcium Channel
	Suvecaltamide (MK-8998) as potent inhibitors of T-type calcium channels.		Calcium Channel
T6571	Lomerizine dihydrochloride	Terranas,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796	Calcium Channel
	Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.		Calcium Channel
T23497	UK 78282 hydrochloride		Potassium Channel
	UK 78282 hydrochloride, a novel potent and selective Kv1.3 blocker.UK 78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.		Potassium Channel
T2323	Efonidipine	(±)-Efonidipine,NZ-105	Calcium Channel
	Efonidipine (NZ-105)(NZ-105) is a dihydropyridine calcium channel blocker, blocking both T-type and L-type calcium channels.		Calcium Channel
T12032	Mibefradil dihydrochloride	Ro 40-5967 (dihydrochloride)	Calcium Channel
	Mibefradil dihydrochloride (Ro 40-5967 (dihydrochloride)) is an blocker of calcium channel with moderate selectivity for T-type Ca2+ channels (T-type and L-type currents with IC50s of 2.7 μM and 18.6 μM, respectively).		Calcium Channel
T37427	(2R/S)-6-PNG	6-Prenylnaringenin,(±)-6-Prenylnaringenin	Calcium Channel , HDAC
	(2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and blocks T-type calcium channels to reduce neuropathic and visceral pain in mice.		Calcium Channel , HDAC
T0267	Zonisamide	AD 810,CI 912	Calcium Channel , Sodium Channel , Carbonic Anhydrase
	Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...		Calcium Channel , Sodium Channel , Carbonic Anhydrase
T25874	NMP-7	NMP7,NMP 7
	NMP-7 is a non-selective CB1 and CB2 cannabinoid receptor agonist that works by blocking T-type calcium channels.
TQ0153	Mibefradil	Ro 40-5967	Calcium Channel
	Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).		Calcium Channel
T12076	ML218 hydrochloride		Others
	ML218 hydrochloride is a selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor (Cav3.2 and Cav3.3 with IC50s of 310 nM and 270 nM , respectively).		Others
T75792	Huwentoxin XVI TFA
	Huwentoxin XVI TFA, a potent analgesic derived from the Chinese tarantula Ornithoctonus huwena, acts as a highly reversible and selective antagonist of mammalian N-type calcium channels (IC 50 of ~60 nM), with no impact ...
T61393	IAA65
	IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].
T63606	Cav 3.2 inhibitor 2
	Cav 3.2 inhibitor 2 is an inhibitor of Cav3.2 T-type Ca2+channels with an IC50=0.09339 μM at a constant potential of -80 mV. Cav 3.2 inhibitor 2 exhibits potent inhibition of T-channel-dependent somatic and visceral pain...
T61747	TTA-P1
	TTA-P1 is a highly potent compound that effectively inhibits human T-type calcium channels, which are involved in various physiological processes such as neuronal burst firing, hormone secretion, and cell growth. With it...