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Search Results for " rna-dependent "

Targets

77

Compounds

7

Natural Products

77

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T14495 Baloxavir Baloxavir acid,S-033447 Influenza Virus
Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
T4686 Simeprevir TMC435,TMC-435350,Olysio HCV Protease , SARS-CoV
Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.
T8972 FIT-039 Others , DNA/RNA Synthesis , CDK , HSV
FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...
T5539 GS-443902 Nucleoside Antimetabolite/Analog , HCV Protease , SARS-CoV , DNA/RNA Synthesis , RSV , Drug Metabolite
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks
T6833 Favipiravir T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis
Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
T27696 JTK-109 JTK109 HCV Protease
JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
T1501 Rifabutin LM-427,Ansamycin HSP , DNA/RNA Synthesis , Antibacterial , Antibiotic
Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin...
T15282 Filibuvir PF-00868554 HCV Protease , DNA/RNA Synthesis
Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.
T9617 RdRP-IN-2 SARS-CoV
RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. It significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.It also inhibits Feline coronavirus (FIPV) replication.
T9618 HeE1-2Tyr SARS-CoV
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro.
TQ0090 Nesbuvir HCV-796 HCV Protease
Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons.
T82568 DHX9-IN-2 DNA/RNA Synthesis
DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.
T3489 Dasabuvir ABT-333 HCV Protease
Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...
T1154 Rifaximin DNA/RNA Synthesis , Antibacterial , Antibiotic
Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting...
T11760 KIN101 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene HCV Protease , Influenza Virus , RSV , Antifection
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and R...
T19836 2-Aminopurine DNA/RNA Synthesis , PKA
2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.
T77520 AOH1996 Apoptosis , DNA/RNA Synthesis
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ...
T27260 Emivirine MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302 HIV Protease
Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.
T10491L Galidesivir hydrochloride BCX 4430 hydrochloride,Immucillin-A hydrochloride Others
Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.
T71748 RK-0404678
RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities.
T40267 RdRP-IN-3
RdRP-IN-3 is a promising anti-influenza drug candidate by inhibiting the activity of RNA-dependent RNA polymerase (RdRp) .
T28538 Rifamycin SV
Rifamycin SV, a natural antibiotic, blocks RNA-polymerase transcription initiation, modulating ß2m aggregation; inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis.
T21225 Rifamycin Rifocin,Rifamycin SV
Rifamycin, a natural antibiotic, inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis, leading to the block of RNA-polymerase transcription initiation.
T71825 BEPP monohydrochloride
BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator.
T27485 GSK-625433
GSK-625433, a homochiral inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, has the ability to inhibit the polymerase of both HCV genotypes 1a and 1b.
T63598 DENV-IN-4
DENV-IN-4 is a potent inhibitor of DENV (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). The antiviral effect was demonstrated by the concentration-dependent reduction of DENV2 expression and the inhibition of RNA-depende...
T10493 Beclabuvir BMS-791325 Others
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).
T11062 DmDNA31 Others
dmDNA31 is a rifamycin antibiotic that can inhibit the DNA-dependent RNA polymerase of bacteria and has strong bactericidal activity against Staphylococcus aureus.
T70855 Favipiravir sodium
Favipiravir sodium is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as o...
T11352 Galidesivir triphosphate BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870 Others
Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA pol...
T25106 Aranotin L53185,Lilly 53185,L 53185,L-53185,Antibiotic A 21101-IL
Aranotin is a fungal toxin isolated from Arachniotus aureus with activity against RNA viruses such as poliovirus, coxsackie virus, and rhino- and parainfluenza viruses. Aranotin inhibits viral RNA synthesis by impeding t...
T10491 Galidesivir BCX4430,Immucillin-A Others
Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and re...
T73323 RdRP-IN-5 Influenza Virus
RdRP-IN-5 (compound 20), a potent inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), has potential application in influenza research [1].
T38616 Teprasiran QPI-1002
Teprasiran (QPI-1002) is an RNA-based compound that transiently suppresses p53-dependent apoptosis, a process involved in the development of acute kidney injury (AKI).
T41177 Galidesivir dihydrochloride BCX 4430
Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arena...
T72792 Trans-RdRP-IN-5
trans-RdRP-IN-5 is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. trans-RdRP-IN-5 can be used in research of influenza virus .
T63073 Cap-dependent endonuclease-IN-19
Cap-dependent endonuclease-IN-19 is a spirocyclic pyridinone derivative and a potent inhibitor of cap-dependent nucleic acid endonuclease (CEN). cap-dependent endonuclease-IN-19 potently inhibits the RNA polymerase activ...
T38761 GS-443902 trisodium GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium
GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC 50 s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the act...
T62160 AS-136A
AS-136A is an orally active, non-nucleoside inhibitor of measles virus RNA-dependent RNA polymerase (RdRp) that acts against measles virus (IC50: 2 μM).
T72896 Cis-RdRP-IN-5
cis-RdRP-IN-5 is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. cis-RdRP-IN-5 can be used in research of influenza virus .
T83251 7-51A Influenza Virus
7-51A is an effective inhibitor of the PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRP), with a dissociation constant (K_D) of 1.64 nM as determined by isothermal titration calorimetry (ITC).
T64177 Cap-dependent endonuclease-IN-2
Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent nucleic acid endonucleases (CEN). Cap-dependent endonuclease-IN-2 significantly inhibits influenza A virus RNA polymerase activity.
T16749 Rifalazil KRM-1648,ABI-1648 DNA/RNA Synthesis
Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is an antibiotic, exhibits high potency agains...
T79233 RdRP-IN-6 DNA/RNA Synthesis
RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM. It has potential applications in antiviral and anticancer research [1].
T83295 5-Azacytidine 5′-triphosphate sodium
5-Azacytidine 5'-triphosphate sodium, a cytidine analog, selectively inhibits the incorporation of [3 H]CTP into RNA by DNA-dependent RNA polymerase, without affecting the incorporation of [3 H]UTP [1].
T83296 5-Azacytidine 5′-triphosphate
5-Azacytidine 5′-triphosphate (5-aza-CMP), a cytidine analog, selectively inhibits the incorporation of [^3H]CTP into RNA during the DNA-dependent RNA polymerase reaction, while not affecting the incorporation of [^3H]UT...
T67814 TMC-649128 PM
TMC-649128 PM is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC(50) value of 1.2 muM and showing moderate in vivo bioavailability in rat (F=14%).
T40616 8-Azido-ATP 8-Azidoadenosine 5'-triphosphate,8-N3-ATP,8-Azido-ATP
8-Azido-ATP is a nucleotide analog that demonstrates photo-reactivity properties. It offers utility in the precise labeling and identification of proteins, particularly those involved in DNA-dependent RNA polymerase acti...
T35533 6-Hydroxypyridin-3-ylboronic Acid
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B)...
T35657 3'-Deoxyuridine-5'-triphosphate
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into ...

Compounds

Baloxavir
T14495
Synonym: Baloxavir acid,S-033447
Target: Influenza Virus
Simeprevir
T4686
Synonym: TMC435,TMC-435350,Olysio
Target: HCV Protease, SARS-CoV
FIT-039
T8972
Synonym:
Target: Others, DNA/RNA Synthesis, CDK, HSV
GS-443902
T5539
Synonym:
Target: Nucleoside Antimetabolite/Analog, HCV Protease, SARS-CoV, DNA/RNA Synthesis, RSV, Drug Metabolite
Favipiravir
T6833
Synonym: T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide
Target: Others, SARS-CoV, Influenza Virus, DNA/RNA Synthesis
JTK-109
T27696
Synonym: JTK109
Target: HCV Protease
Rifabutin
T1501
Synonym: LM-427,Ansamycin
Target: HSP, DNA/RNA Synthesis, Antibacterial, Antibiotic
Filibuvir
T15282
Synonym: PF-00868554
Target: HCV Protease, DNA/RNA Synthesis
RdRP-IN-2
T9617
Synonym:
Target: SARS-CoV
HeE1-2Tyr
T9618
Synonym:
Target: SARS-CoV
Nesbuvir
TQ0090
Synonym: HCV-796
Target: HCV Protease
DHX9-IN-2
T82568
Synonym:
Target: DNA/RNA Synthesis
Dasabuvir
T3489
Synonym: ABT-333
Target: HCV Protease
Rifaximin
T1154
Synonym:
Target: DNA/RNA Synthesis, Antibacterial, Antibiotic
KIN101
T11760
Synonym: 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene
Target: HCV Protease, Influenza Virus, RSV, Antifection
2-Aminopurine
T19836
Synonym:
Target: DNA/RNA Synthesis, PKA
AOH1996
T77520
Synonym:
Target: Apoptosis, DNA/RNA Synthesis
Emivirine
T27260
Synonym: MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302
Target: HIV Protease
Galidesivir hydrochloride
T10491L
Synonym: BCX 4430 hydrochloride,Immucillin-A hydrochloride
Target: Others
RK-0404678
T71748
Synonym:
Target:
RdRP-IN-3
T40267
Synonym:
Target:
Rifamycin SV
T28538
Synonym:
Target:
Rifamycin
T21225
Synonym: Rifocin,Rifamycin SV
Target:
BEPP monohydrochloride
T71825
Synonym:
Target:
GSK-625433
T27485
Synonym:
Target:
DENV-IN-4
T63598
Synonym:
Target:
Beclabuvir
T10493
Synonym: BMS-791325
Target: Others
dmDNA31
T11062
Synonym:
Target: Others
Favipiravir sodium
T70855
Synonym:
Target:
Galidesivir triphosphate
T11352
Synonym: BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870
Target: Others
Aranotin
T25106
Synonym: L53185,Lilly 53185,L 53185,L-53185,Antibiotic A 21101-IL
Target:
Galidesivir
T10491
Synonym: BCX4430,Immucillin-A
Target: Others
RdRP-IN-5
T73323
Synonym:
Target: Influenza Virus
Teprasiran
T38616
Synonym: QPI-1002
Target:
Galidesivir dihydrochloride
T41177
Synonym: BCX 4430
Target:
trans-RdRP-IN-5
T72792
Synonym:
Target:
Cap-dependent endonuclease-IN-19
T63073
Synonym:
Target:
GS-443902 trisodium
T38761
Synonym: GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium
Target:
AS-136A
T62160
Synonym:
Target:
cis-RdRP-IN-5
T72896
Synonym:
Target:
7-51A
T83251
Synonym:
Target: Influenza Virus
Cap-dependent endonuclease-IN-2
T64177
Synonym:
Target:
Rifalazil
T16749
Synonym: KRM-1648,ABI-1648
Target: DNA/RNA Synthesis
RdRP-IN-6
T79233
Synonym:
Target: DNA/RNA Synthesis
5-Azacytidine 5′-triphosphate sodium
T83295
Synonym:
Target:
5-Azacytidine 5′-triphosphate
T83296
Synonym:
Target:
TMC-649128 PM
T67814
Synonym:
Target:
8-Azido-ATP
T40616
Synonym: 8-Azidoadenosine 5'-triphosphate,8-N3-ATP,8-Azido-ATP
Target:
6-Hydroxypyridin-3-ylboronic Acid
T35533
Synonym:
Target:
3'-Deoxyuridine-5'-triphosphate
T35657
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T17143 Toyocamycin Vengicide Apoptosis , Others , IRE1 , Antibiotic , Antifungal
Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.
TN1258 3-Acetyl-beta-boswellic acid 3-O-Acetyl-beta-boswellic acid DNA/RNA Synthesis
3-Acetyl-beta-boswellic acid has antitumor activity, it inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 microM.
T8347 Rifamycin S Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
T5003 Rifamycin sodium Rifamycin sodium salt Antibacterial , Antibiotic
Rifamycin sodium (Rifamycin sodium salt) salt is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase. It is effective against Gram-positive bacteria.
T5075 Phytic acid potassium Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt Others , Endogenous Metabolite
Phytic acid potassium (Inositol polyphosphate dipotassium salt) exists in all eukaryotic cells. In plants, it is known to function as a [PO4]3 storage depot and precursor for other inositol phosphates and pyrophosphates....
TN2222 Sotetsuflavone Others
Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 μM, is the most active compound of this series.
T11233 Erythromycin thiocyanate Antibacterial
Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nuc...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-06071 SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His) SARS-CoV-2 Baculovirus-Insect Cells
TMPY-02219 Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) H1N1 E. coli
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the N...
TMPH-00681 SsPB Protein, E. coli O157:H7, Recombinant (His) E. coli E. coli
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. RNA-dependent NTPase wh...
TMPY-05024 Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS5 protein (His) ZIKV Baculovirus-Insect Cells
Zika virus NS5 is involved in methytransferase and RNA guanylytransferase activities and capping and synthesis of RNA. And, NS5 is also an RNA-dependent RNA polymerase.
TMPH-02864 Wnt1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Rna-dependent RNA polymerase part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them.
TMPY-05749 SARS-CoV-2 NSP8 Protein (Avi) SARS-CoV-2 E. coli
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarka...
TMPY-06416 SARS-CoV-2 NSP8 Protein SARS-CoV-2 E. coli
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarka...
TMPH-03071 TAP Protein, Ornithodoros moubata, Recombinant (His & Myc & SUMO) Ornithodoros moubata E. coli
Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase...
TMPH-00672 Metalloprotease stcE Protein, E. coli O157:H7, Recombinant (His) E. coli E. coli
GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splici...
TMPH-01184 CYP2A6 Protein, Human, Recombinant (His & Myc) Human E. coli
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary str...
TMPH-01132 Complement C8a Protein, Human, Recombinant (His) Human E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs....
TMPH-02140 CYP21A2 Protein, Human, Recombinant (E. coli, His) Human E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precurs...
TMPH-02145 MMP-3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary ...
TMPH-02907 Sialidase-3 Protein, Mouse, Recombinant (His) Mouse E. coli
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from...
TMPY-05752 SARS-CoV-2 3CLpro/3C-like protease Protein (His) SARS-CoV-2 Baculovirus-Insect Cells
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPH-01484 SMYD3 Protein, Human, Recombinant (His & Myc) Human E. coli
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory...
TMPH-01247 POLR3K Protein, Human, Recombinant (His) Human Baculovirus
ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged ...
TMPH-01133 Complement C8b Protein, Human, Recombinant (His) Human E. coli
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
TMPH-01134 Complement C8g Protein, Human, Recombinant (His) Human E. coli
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
TMPY-05727 SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi) SARS-CoV-2 E. coli
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPJ-01428 SARS-CoV-2 NSP8 Protein (His) SARS-CoV-2 E. coli
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are...
TMPH-00518 StxB2 Protein, Enterobacteria phage 933W, Recombinant (His & SUMO) Enterobacteria phage 933W E. coli
One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.; With S5 and S12 plays an important role in translational accuracy; ma...
TMPH-02905 TRPC1 Protein, Mouse, Recombinant (His) Mouse in vitro E. coli expression system
Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction w...
TMPH-01920 P4HA3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mR...
TMPH-01958 Wnt2 Protein, Human, Recombinant (His) Human Baculovirus
RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized withi...
TMPH-02906 Sialidase-1 Protein, Mouse, Recombinant (His) Mouse E. coli
Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction w...
TMPY-02311 AGO3 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Argonaute (Ago) protein family plays a key role in the RNA interference (RNAi) process in different insects including Lepidopteran. AGO3 also coexists and interacts with Armitage in the mitochondrial fraction. Furthermo...
TMPH-03734 Zaire ebolavirus (strain Mayinga-76) L Protein (His) ZEBOV E. coli
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras...
TMPH-03735 Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc) ZEBOV E. coli
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras...
TMPH-02144 Striatin-3 Protein, Human, Recombinant (His) Human E. coli
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras...
TMPH-03491 SARS-CoV-2 Non-structural protein 9/NSP9 Protein (His) SARS-CoV-2 E. coli
The recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 9 (NSP9) is a full-length protein expressed in E.coli. It contains the 1-113 amino acid sequence of human SARS-CoV-2 and...
TMPH-01922 Promotilin Protein, Human, Recombinant (GST & His & Myc) Human E. coli
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the b...
TMPH-02152 Sucrase-isomaltase/SI Protein, Human, Recombinant (His) Human Baculovirus
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host...
TMPH-02151 OXCT1 Protein, Human, Recombinant (His) Human E. coli
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host...
TMPH-00493 IL-13 Protein, Canine, Recombinant (His) Canine E. coli
Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short tr...
TMPH-02126 SORBS2 Protein, Human, Recombinant (His) Human E. coli
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host...
TMPH-01131 Complement C4-B Protein, Human, Recombinant (His & SUMO) Human E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs,...
TMPH-00704 PatZ Protein, E. coli, Recombinant (His & Myc) E. coli E. coli
The authors present evidence that the transcription of the Gcn5-like acetyltransferase YfiQ of Escherichia coli (proposed name: PatZ) is regulated by cAMP-CRP and its implications on acetate metabolism regulation. PMID: ...
TMPH-00120 Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc) Aspergillus clavatus E. coli
The authors present evidence that the transcription of the Gcn5-like acetyltransferase YfiQ of Escherichia coli (proposed name: PatZ) is regulated by cAMP-CRP and its implications on acetate metabolism regulation. PMID: ...
TMPH-01529 INMT Protein, Human, Recombinant (His & SUMO) Human E. coli
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in ...
TMPH-00468 Interferon-inducible MxA protein Protein, Danio rerio, Recombinant (His) Danio rerio (Zebrafish) E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors a...
TMPY-04775 CDK1 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote...
TMPY-04549 CDK1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote...
TMPH-01966 PADI2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active de...
TMPH-02632 TRIM21 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic c...
TMPJ-01425 SARS-CoV-2 NSP1 Protein (His) SARS-CoV-2 E. coli
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, po...
TMPY-03288 USP30 Protein, Human, Recombinant (SUMO) Human Baculovirus-Insect Cells
Ubiquitin specific peptidase 30, also known as USP30, is a deubiquitinating enzyme that is embedded in the mitochondrial outer membrane. Depletion of USP30 expression by RNA interference induced elongated and interconnec...
TMPH-02514 APOA4 Protein, Mouse, Recombinant (His) Mouse Yeast
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ...
TMPH-02097 PPP5C Protein, Human, Recombinant (His & Myc) Human E. coli
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitme...
TMPH-00778 IFN gamma Protein, Guinea Pig, Recombinant (His) Guinea pig E. coli
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stran...
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SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His)
TMPY-06071
Species: SARS-CoV-2
Expression System: Baculovirus-Insect Cells
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
TMPY-02219
Species: H1N1
Expression System: E. coli
ssPB Protein, E. coli O157:H7, Recombinant (His)
TMPH-00681
Species: E. coli
Expression System: E. coli
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS5 protein (His)
TMPY-05024
Species: ZIKV
Expression System: Baculovirus-Insect Cells
Wnt1 Protein, Mouse, Recombinant (His & Myc)
TMPH-02864
Species: Mouse
Expression System: E. coli
SARS-CoV-2 NSP8 Protein (Avi)
TMPY-05749
Species: SARS-CoV-2
Expression System: E. coli
SARS-CoV-2 NSP8 Protein
TMPY-06416
Species: SARS-CoV-2
Expression System: E. coli
TAP Protein, Ornithodoros moubata, Recombinant (His & Myc & SUMO)
TMPH-03071
Species: Ornithodoros moubata
Expression System: E. coli
Metalloprotease stcE Protein, E. coli O157:H7, Recombinant (His)
TMPH-00672
Species: E. coli
Expression System: E. coli
CYP2A6 Protein, Human, Recombinant (His & Myc)
TMPH-01184
Species: Human
Expression System: E. coli
Complement C8a Protein, Human, Recombinant (His)
TMPH-01132
Species: Human
Expression System: E. coli
CYP21A2 Protein, Human, Recombinant (E. coli, His)
TMPH-02140
Species: Human
Expression System: E. coli
MMP-3 Protein, Human, Recombinant (His & SUMO)
TMPH-02145
Species: Human
Expression System: E. coli
Sialidase-3 Protein, Mouse, Recombinant (His)
TMPH-02907
Species: Mouse
Expression System: E. coli
SARS-CoV-2 3CLpro/3C-like protease Protein (His)
TMPY-05752
Species: SARS-CoV-2
Expression System: Baculovirus-Insect Cells
SMYD3 Protein, Human, Recombinant (His & Myc)
TMPH-01484
Species: Human
Expression System: E. coli
POLR3K Protein, Human, Recombinant (His)
TMPH-01247
Species: Human
Expression System: Baculovirus
Complement C8b Protein, Human, Recombinant (His)
TMPH-01133
Species: Human
Expression System: E. coli
Complement C8g Protein, Human, Recombinant (His)
TMPH-01134
Species: Human
Expression System: E. coli
SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)
TMPY-05727
Species: SARS-CoV-2
Expression System: E. coli
SARS-CoV-2 NSP8 Protein (His)
TMPJ-01428
Species: SARS-CoV-2
Expression System: E. coli
StxB2 Protein, Enterobacteria phage 933W, Recombinant (His & SUMO)
TMPH-00518
Species: Enterobacteria phage 933W
Expression System: E. coli
TRPC1 Protein, Mouse, Recombinant (His)
TMPH-02905
Species: Mouse
Expression System: in vitro E. coli expression system
P4HA3 Protein, Human, Recombinant (His & SUMO)
TMPH-01920
Species: Human
Expression System: E. coli
Wnt2 Protein, Human, Recombinant (His)
TMPH-01958
Species: Human
Expression System: Baculovirus
Sialidase-1 Protein, Mouse, Recombinant (His)
TMPH-02906
Species: Mouse
Expression System: E. coli
AGO3 Protein, Human, Recombinant (His)
TMPY-02311
Species: Human
Expression System: Baculovirus-Insect Cells
Zaire ebolavirus (strain Mayinga-76) L Protein (His)
TMPH-03734
Species: ZEBOV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc)
TMPH-03735
Species: ZEBOV
Expression System: E. coli
Striatin-3 Protein, Human, Recombinant (His)
TMPH-02144
Species: Human
Expression System: E. coli
SARS-CoV-2 Non-structural protein 9/NSP9 Protein (His)
TMPH-03491
Species: SARS-CoV-2
Expression System: E. coli
Promotilin Protein, Human, Recombinant (GST & His & Myc)
TMPH-01922
Species: Human
Expression System: E. coli
Sucrase-isomaltase/SI Protein, Human, Recombinant (His)
TMPH-02152
Species: Human
Expression System: Baculovirus
OXCT1 Protein, Human, Recombinant (His)
TMPH-02151
Species: Human
Expression System: E. coli
IL-13 Protein, Canine, Recombinant (His)
TMPH-00493
Species: Canine
Expression System: E. coli
SORBS2 Protein, Human, Recombinant (His)
TMPH-02126
Species: Human
Expression System: E. coli
Complement C4-B Protein, Human, Recombinant (His & SUMO)
TMPH-01131
Species: Human
Expression System: E. coli
PatZ Protein, E. coli, Recombinant (His & Myc)
TMPH-00704
Species: E. coli
Expression System: E. coli
Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc)
TMPH-00120
Species: Aspergillus clavatus
Expression System: E. coli
INMT Protein, Human, Recombinant (His & SUMO)
TMPH-01529
Species: Human
Expression System: E. coli
Interferon-inducible MxA protein Protein, Danio rerio, Recombinant (His)
TMPH-00468
Species: Danio rerio (Zebrafish)
Expression System: E. coli
CDK1 Protein, Mouse, Recombinant (His & GST)
TMPY-04775
Species: Mouse
Expression System: Baculovirus-Insect Cells
CDK1 Protein, Human, Recombinant (GST)
TMPY-04549
Species: Human
Expression System: Baculovirus-Insect Cells
PADI2 Protein, Human, Recombinant (His & SUMO)
TMPH-01966
Species: Human
Expression System: E. coli
TRIM21 Protein, Mouse, Recombinant (E. coli, His)
TMPH-02632
Species: Mouse
Expression System: E. coli
SARS-CoV-2 NSP1 Protein (His)
TMPJ-01425
Species: SARS-CoV-2
Expression System: E. coli
USP30 Protein, Human, Recombinant (SUMO)
TMPY-03288
Species: Human
Expression System: Baculovirus-Insect Cells
APOA4 Protein, Mouse, Recombinant (His)
TMPH-02514
Species: Mouse
Expression System: Yeast
PPP5C Protein, Human, Recombinant (His & Myc)
TMPH-02097
Species: Human
Expression System: E. coli
IFN gamma Protein, Guinea Pig, Recombinant (His)
TMPH-00778
Species: Guinea pig
Expression System: E. coli
Cat No. Product Name
L6120 Flavonoid Natural Product Library

477 compounds
A unique collection of 477 flavonoids can be used for high throughput and high content screening;
L1710 Anti-COVID-19 Compound Library

1160 compounds
A unique collection of 1160 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents;
TargetMol