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Poly(A) polymerase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    32
    TargetMol | Inhibitors_Agonists
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    2
    TargetMol | Dye_Reagents
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Poly(A) polymerase
T799269026-30-6
Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP. This modification enhances RNA stability and augments mRNA translation efficiency in eukaryotic cells, evidencing the enzyme's high tailing efficiency [1] [2].
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Niraparib metabolite M1
Niraparib carboxylic acid metabolite M1, M1 metabolite of niraparib
T122291476777-06-6In house
Niraparib metabolite M1 (Niraparib carboxylic acid metabolite M1) is the carboxylic acid metabolite of Niraparib. Niraparib is a novel poly (ADP-ribose) polymerase (PARP) inhibitor used in cancer research.
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6-8 weeks
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Daphnetin
Daphnetol, 7,8-Dihydroxycoumarin
T2851486-35-1
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-inflammatory activities.
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Benzamide
Amid kyseliny benzoove, Phenylcarboxyamide, Benzoylamide
T678055-21-0
Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
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Niraparib metabolite M1 HCl
Niraparib metabolite M1 HCl (1476777-06-6 Free base), Niraparib carboxylic acid metabolite M1 HCl, M1 metabolite of niraparib HCl
T12229L
Niraparib metabolite M1 HCl is the active metabolite of Niraparib, as a novel targeted ADP ribose polymerase (PARP) inhibitor, it can competitively inhibit PARP1 and PARP2 to block the DNA repair mechanism of tumor cells and thus effectively inhibit the growth and proliferation, which is commonly used in the study of ovarian cancer, fallopian tube cancer and primary peritoneal cancer, and is commonly used in the study of ovarian, fallopian tube and primary peritoneal cancers.
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PARPYnD
T411762561483-27-8In house
PARPYnD is a potent photoaffinity probe for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). PARPYnD labels PARP1 and PARP2 in the cell when an N3 functionalized fluorescent probe is attached and can inhibit isolated PARP6.
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8-10 weeks
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A-966492
T6366934162-61-5
A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.
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TargetMol | Inhibitor Sale
PARP/PI3K-IN-1
T123652337386-47-5
PARP PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.
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6-8 weeks
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WD2000-012547
T13333283172-68-9
WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221).
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6-8 weeks
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DR2313
DR 2313
T22749284028-90-6
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.
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TargetMol | Inhibitor Sale
CAY10753
T36702
CAY10753 is an inhibitor of tankyrase 2 (TNKS2; IC50= 0.3 nM).1It is selective for TNKS2 over TNKS1 (IC50= 6.1 nM), as well as poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 89.6 and 37.8 nM, respectively). CAY10753 inhibits proliferation of DLD-1 colorectal cancer cells when used at a concentration of 1 μM. 1.Tomassi, S., Pfahler, J., Mautone, N., et al.From PARP1 to TNKS2 inhibition: A structure-based approachMed. Chem. Lett.(2020)
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CAY10760
T36703391889-85-3
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib . 1.Bagnolini, G., Milano, D., Manerba, M., et al.Synthetic lethality in pancreatic cancer: Discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparibJ. Med. Chem.63(5)2588-2619(2020)
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6-8 weeks
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Benzamide-15N
Phenylamide-15N,Benzenecarboxamide-15N,NSC-3114-15N,Benzamide-15N
T4039431656-62-9
Benzamide-15N (NSC-3114-15N) is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP).
    7-10 days
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    pNP-ADPr
    pNP-ADPr, ADP-ribose-pNP
    T41083939028-75-8
    pNP-ADPr is a colorimetric substrate used in continuous activity assays for Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3), aiding research on poly(ADP-ribose) polymerase (PARP) enzymes.
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    TIQ-A
    T50098420849-22-5
    TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions includi
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    INO-1001
    T62527501364-82-5
    INO-1001 is a potent, selective poly(ADP-ribose) polymerase (PARP) inhibitor with antitumor activity.INO-1001 is a potent radiosensitization enhancer that uses interference with DNA repair mechanisms to enhance radiation-induced cell killing and necrotic cell death.
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    7-10 days
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    WP-1034
    T68536857064-42-7
    WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP).
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    6-8 weeks
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    ku-0058948
    T68736763111-49-5
    KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor that induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro.
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    6-8 weeks
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    NU1064
    T6895263916-38-1
    NU1064 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which can potentiate the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1064 potentiated a sublethal concentration of a DNA methylating agent in a concentration-dependent manner.
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    6-8 weeks
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    BIM-46174
    BIM46174, BIM 46174
    T70039195450-11-4
    BIM-46174 is a 5,6,7,8-tetrahydroimidazole [1,2-a] pyrazine derivative that inhibits the heterotrimeric Galpha Gbetagamma protein complex and has anticancer activity, inhibiting the growth of a large number of human cancer cell lines, inducing caspase-3-dependent cancer cell apoptosis, and inducing poly (ADP-ribose) polymerase cleavage.
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    6-8 weeks
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    NU1085
    T71908188106-83-4
    NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP + - NU1085 (10 microM) for 72 h.
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    6-8 weeks
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    PD-128763
    T71966129075-56-5
    PD-128763 is a selective inhibitor of poly(ADP-ribose) polymerase. PD-128763 has an IC50 value against the purified enzyme approximately 50X lower than 3-aminobenzamide (3-AB), a widely used specific inhibitor of the enzyme. Exposure of exponentially growing cells to a noncytotoxic concentration (0.5 mM) of PD 128763 for 2 h immediately following X irradiation increased their radiation sensitivity, modifying both the shoulder and the slope of the survival curve. When recovery from sublethal damage and potentially lethal damage was examined in exponential and plateau-phase cells, respectively, postirradiation incubation with 0.5 mM PD 128763 was found not only to inhibit both these processes fully, but also to enhance further the level of radiation-induced cell killing. This is in contrast to the slight effect seen with the less potent inhibitor, 3-AB. The results presented suggest that the mechanism of radiosensitization by PD 128763 is related to the potent inhibition of pol......
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    6-8 weeks
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    6(5H)-Phenanthridinone
    T720171015-89-0
    6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimental autoimmune encephalomyelitis (EAE). It also decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels.
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    6-8 weeks
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    ARTD10/PARP10-IN-1
    T725531708103-76-7
    ARTD10 PARP10-IN-1 is a potent PARP inhibitor of the mono-ADP ribosyltransferases ARTD7 PARP15, ARTD8 PARP14, ARTD10 PARP10 and poly ADP-ribose polymerase-1 (ARTD1 PARP1), with potential anticancer and antitumour activity for the study of prostate and breast cancers.
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    6-8 weeks
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