Search Result

Search Results for " k562 "

Targets

Apoptosis Adrenergic Receptor Autophagy Imidazoline Receptor

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T6641	Rilmenidine Phosphate		Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor
	Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.
T1448	Dasatinib	BMS-354825	Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy
	Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitumor activity and is used in the treatment of leukemia and ly...		Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy
T13224	Tubulin inhibitor 6	iHAP1	Microtubule Associated
	Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.		Microtubule Associated
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl
T2394	Pixantrone dimaleate	BBR-2778,Pixantrone Maleate,BBR 2778 dimaleate	Topoisomerase
	Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.		Topoisomerase
T1448L	Dasatinib monohydrate	BMS-354825 Monohydrate	Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy
	Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit...
T24838	Stafib-1	Stafib 1,Stafib1	STAT
	Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.		STAT
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T6018	Zosuquidar trihydrochloride	Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride	P-gp
	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.		P-gp
T16940	STAT5-IN-2		Apoptosis , STAT
	STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).		Apoptosis , STAT
T2539	Fingolimod hydrochloride	Fingolimod (FTY720) HCl,FTY720	TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
	Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).		TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
T1937	Spautin-1	Spautin 1	Apoptosis , DUB , Autophagy
	Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.		Apoptosis , DUB , Autophagy
T74186	PROTAC-O4I2		Apoptosis , PROTACs
	PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells.		Apoptosis , PROTACs
T13226	Tubulin inhibitor 8		Microtubule Associated
	Tubulin inhibitor 8 is an inhibitor of tubulin and various cancer cell lines and inhibits tubulin polymerisation and K562 cell growth with an IC50 of 0.73 μM and 14 nM respectively.		Microtubule Associated
T12341	P-gp inhibitor 1		Others , P-gp
	P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).		Others , P-gp
T28475	Pyrazoloacridine	PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934	Apoptosis , Topoisomerase
	Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.		Apoptosis , Topoisomerase
T77728	Tubulin polymerization-IN-55		Microtubule Associated
	Tubulin polymerization-IN-55 is a potent Tubulin Polymerization inhibitor with potential anti-angiogenic and anti-tumour activity, showing anti-proliferative effects against A549, K562, HepG2, MDA-MB-231 and HFL-1.		Microtubule Associated
T6691	TAI-1		Apoptosis , Microtubule Associated
	TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.		Apoptosis , Microtubule Associated
T12926	SJB3-019A		Others , DUB
	SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits...		Others , DUB
T62745	AMPK-IN-3		VEGFR , AMPK
	AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cell...		VEGFR , AMPK
T4595	YHO-13177	YHO 13177,YHO13177	BCRP
	YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.		BCRP
T24912	Tyrphostin AG 568	Tyrphostin AG-568,Tyrphostin AG568
	Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate.
T82715	Cisplatin-resistant cells-IN-1
	Cisplatin-resistant cells-IN-1 (Compound 8) exhibits high cytotoxicity against Cisplatin-resistant cells and effectively diminishes metabolic activity at low nanomolar concentrations, with an IC50 ranging from 0.14 to 1....
T23617	Aclacinomycin	Aclacinomycins,Siwenmycin
	Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer.
T24911	Tyrphostin AG 1112	Tyrphostin AG-1112,Tyrphostin AG1112
	Tyrphostin AG 1112 is a Bcr-Abl kinase blocker. It can activate the terminal differentiation of K562 cells and the purging of Ph+ cells.
T82774	Caspase-3 activator 3		Caspase
	Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively...		Caspase
T13225	Tubulin inhibitor 7		Microtubule Associated
	Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (IC50: 11 nM)).		Microtubule Associated
T28092	MPT0B206
	MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1...
T63159	Anticancer agent 28
	Anticancer agent 28 showed good anti-tumour effects in vivo in H22 allograft mice. anticancer agent 28 was 50 times more potent than Oridonin against K562 cells with an IC50 value of 0.09 μM.
T37544	Anhydroophiobolin A
	Anhydroophiobolin A is an ophiobolin fungal metabolite that has been found in C. heterostrophus fermentation broths. It is cytotoxic to HepG2 and K562 cancer cells (IC50s = 55.7 and 39.5 μM, respectively).
T1817	GNF-2	GNF2	SARS-CoV , Bcr-Abl
	GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.		SARS-CoV , Bcr-Abl
T33510	MS-073	CP162398,CP-162398,CP 162398,MS 073
	MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp). The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, an...
T73451	BAY-364	BAY-299N
	BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+ cells, and K562 cells with respective IC50 values of 1.0 µM, 10....
T63932	BCR-ABL-IN-4
	BCR-ABL-IN-4 is a BCR-ABLL inhibitor that exhibits anticancer activity.BCR-ABL-IN-4 has an inhibitory effect on cancer cell growth and is able to act on K562 cells (IC50: 0.67 nM) and BCR-ABL T315I-transfected Ba/F3 cell...
T37804	8MDP
	Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively. Lin et al (2011) Design, synthesis, and evaluat...
T62637	EIF2α activator 2
	EIF2α activator 2 (Compound 1) is a phosphorylated activator of eukaryotic initiation factor 2α (eIF2α). EIF2α activator 2 is anti-proliferative in K562 cells (IC50: 4.79 μM) and PBMC cells (IC50: 10.52 μM).
T82775	Caspase-3 activator 2		Caspase
	Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM, respectively [1]. It facilitates apoptosis, rendering it usef...		Caspase
T78815	MOZ-IN-3		Histone Acetyltransferase
	MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemia cell lines, including HL-60, U937, SKNO-1, and K562. This comp...		Histone Acetyltransferase
T77974	PROTAC BCR-ABL Degrader-1		PROTACs
	PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway and demonstrates antiproliferative effects on K562 cells, suggesting its...		PROTACs
T79754	JNK-IN-14		JNK
	JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3. It induces early-stage apoptosis, arrests cell population at the G2/M phase, and moderately inhibits be...		JNK
T37423	Reveromycin D
	Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μ...
T62217	Tubulin polymerization-IN-9
	Tubulin polymerization-IN-9 is a potent inhibitor of tubulin (IC50: 1.82 μM). Tubulin polymerization-IN-9 arrests the cell cycle of K562 cells in G2/M phase and induces apoptosis and mitochondrial depolarization. Tubulin...
T63665	EIF2α activator 1
	EIF2α Activator 1 (Compound 40) is a chemical compound that activates the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α), enhancing the expression of downstream proteins ATF and CHOP. It demonstrates ant...
T38044	Reveromycin B
	Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 μg/ml) and exhibits pH-dependent antifungal activity against...
T78844	MET/PDGFRA-IN-2		c-Met/HGFR
	MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positive cells with IC50 values of 9.7, 6.1, 12.0, 11.5, 8.6, and 34.4 μ...		c-Met/HGFR
T21911	Rilmenidine hemifumarate	Rilmenidine (hemifumarate),S-3341 hemifumarate	Apoptosis , Imidazoline Receptor
	Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulate...		Apoptosis , Imidazoline Receptor
T78608	Anticancer agent 164		Apoptosis
	CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid leukemia (CML) cell line K562. It diminishes protein phosph...		Apoptosis
T79322	Antiproliferative agent-30
	Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against HCT-116, K562, and MV-4-11 cancer cell lines, respectively. It...
T78843	MET/PDGFRA-IN-1		c-Met/HGFR
	MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET. It impedes MET phosphorylation, thereby promoting apoptosis, and curtails the proliferation of var...		c-Met/HGFR
T79683	HDAC/CD13-IN-1		Others
	HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μM for HDAC1, HDAC2, and HDAC3, respectively. This compound ef...		Others

Compounds

Rilmenidine Phosphate

T6641

Synonym:

Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor

Dasatinib

T1448

Synonym: BMS-354825

Target: Apoptosis, Bcr-Abl, Src, c-Kit, Autophagy

Tubulin inhibitor 6

T13224

Synonym: iHAP1

Target: Microtubule Associated

Pivanex

T16545

Synonym: Pivalyloxymethyl butyrate,AN-9

Target: Apoptosis, HDAC, Bcr-Abl

Pixantrone dimaleate

T2394

Synonym: BBR-2778,Pixantrone Maleate,BBR 2778 dimaleate

Target: Topoisomerase

Dasatinib monohydrate

T1448L

Synonym: BMS-354825 Monohydrate

Target: Apoptosis, Bcr-Abl, Src, c-Kit, Ephrin Receptor, Autophagy

Stafib-1

T24838

Synonym: Stafib 1,Stafib1

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Zosuquidar trihydrochloride

T6018

Synonym: Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride

Target: Apoptosis, STAT

Fingolimod hydrochloride

T2539

Synonym: Fingolimod (FTY720) HCl,FTY720

Target: TRP/TRPV Channel, S1P Receptor, PAK, LPL Receptor

Spautin-1

T1937

Synonym: Spautin 1

Target: Apoptosis, DUB, Autophagy

PROTAC-O4I2

T74186

Synonym:

Target: Apoptosis, PROTACs

Tubulin inhibitor 8

T13226

Synonym:

Target: Microtubule Associated

Synonym: PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934

Target: Apoptosis, Topoisomerase

Tubulin polymerization-IN-55

T77728

Synonym:

Target: Microtubule Associated

TAI-1

T6691

Synonym:

Target: Apoptosis, Microtubule Associated

Synonym: YHO 13177,YHO13177

Target: BCRP

Tyrphostin AG 568

T24912

Synonym: Tyrphostin AG-568,Tyrphostin AG568

Target:

Cisplatin-resistant cells-IN-1

Synonym: Aclacinomycins,Siwenmycin

Target:

Tyrphostin AG 1112

T24911

Synonym: Tyrphostin AG-1112,Tyrphostin AG1112

Target:

Caspase-3 activator 3

Target: Microtubule Associated

Target: SARS-CoV, Bcr-Abl

MS-073

T33510

Synonym: CP162398,CP-162398,CP 162398,MS 073

Caspase-3 activator 2

Target: Histone Acetyltransferase

PROTAC BCR-ABL Degrader-1

Tubulin polymerization-IN-9

Rilmenidine hemifumarate

T21911

Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate

Target: Apoptosis, Imidazoline Receptor

Antiproliferative agent-30

Cat No.	Product Name	Synonyms	Targets
T0974	Novobiocin Sodium	Albamycinsodium,Cathomycin,Albamycin	Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
	Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T3138	Astaxanthin	β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin	Reactive Oxygen Species , PPAR
	Astaxanthin (trans-Astaxanthin) is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity. It is present in most red-colored aqu...		Reactive Oxygen Species , PPAR
T1511	Daunorubicin hydrochloride	Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy
	Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
T7939	Fingolimod	FTY-720A,FTY-720	S1P Receptor , PAK , LPL Receptor
	Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).		S1P Receptor , PAK , LPL Receptor
T6S1843	Tenacissoside I	Tenacissimoside B	Others
	Tenacissoside I (Tenacissimoside B),Tenacissosides B, C and marsdenoside K inhibit the proliferation of Raji, NB4 and K562 cells in vitro significantly, in a dose and time dependent manner.		Others
TN2755	2-Desoxy-4-epi-pulchellin		Anti-infection
	2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig...		Anti-infection
TN2211	Silybin B	Silibinin B	Apoptosis , Beta Amyloid , Bcr-Abl
	Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-dipheny...		Apoptosis , Beta Amyloid , Bcr-Abl
T4S1943	Kirenol	Kirel	Wnt/beta-catenin
	1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid...		Wnt/beta-catenin
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T3398	Icaritin	Anhydroicaritin,Cycloicaritin	Apoptosis , JAK , STAT , Autophagy
	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica...		Apoptosis , JAK , STAT , Autophagy
T6S1315	Oroxylin A	6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...		Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T81232	S-30-Hydroxygambogic acid
	"S-30-Hydroxygambogic acid, a polyprenylated xanthone epimer isolated from the gamboges of Garcinia hanburyi, exhibits cytotoxicity against Human Leukemia K562 cell lines with IC50 values of 4.49 μM for K562/R and 3.61 μ...
T81318	R-30-Hydroxygambogic acid
	R-30-Hydroxygambogic acid, a polyprenylated xanthone epimer isolated from the gamboge of Garcinia hanburyi, exhibits cytotoxicity against human leukemia K562 cell lines, with IC50 values of 2.89 μM for the resistant stra...
TN5358	Eupahualin C
	Eupahualin C shows significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).
TN5934	2-Hydroxydiplopterol	2,22-Hopanediol
	2-Hydroxydiplopterol exhibits cytotoxicity against K562 cells with an IC50 value of 22 microM.
TN5274	Yunnancoronarin A		Others
	Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM.		Others
TN4011	Erythrodiol 3-palmitate		Others
	Erythrodiol 3-palmitate has antitumor activity, it inhibited the proliferation of K562 cells with the inhibition rate of 47% at 100 ug/mL.		Others
TN4284	Isodonal		Others
	Isodonal shows abilities to inhibit K562 cells camparable to that of cisplatin.		Others
TN3760	Danshenol A		Reductase
	Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and B...		Reductase
T80995	Theasaponin E2
	Theasaponin E2, isolated from Camellia sinensis [1], exhibits cytotoxicity against K562 and HL60 cells with an IC50 of 14.7 μg/mL.
TN4976	Scutebata E		Others
	Scutebata E shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines.		Others
TN2192	Scutebarbatine B		Others
	Scutebarbatine B shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines and HL60 cell lines.		Others
TN2128	Quercetin 3-O-robinobioside		Others
	Quercetin-3-O-robinobioside is a quercetin-derived flavonol, exhibits antioxidant activities. It exhibits in-vitro inhibitory activities against leukemia K562 cells.		Others
TN4215	Hispidanin B		Others
	Hispidanin B shows significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.7, 9.8, and 13.7 uM, respectively.		Others
TN1144	Enmein		Antifection , Immunology/Inflammation related
	Enmein shows significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml		Antifection , Immunology/Inflammation related
TN6054	Norglaucine hydrochloride
	(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and...
T75677	Protoneogracillin
	Protoneogracillin, a furostanol glycoside, demonstrates anti-fungal activity against the plant pathogenic fungus P.oryzae (MMDC=94.0 μM) and exhibits cytotoxic activity against K562 cancer cells (IC 50 =6.6 μM) [1] [2].
TN3417	Angophorol		Apoptosis
	Angophorol is a flavonoid compound from the culm fern, Pterocarpus indicus, in the family Pterocarpaceae.Angophorol exerts potential anticancer activity through growth inhibition and apoptosis in K562 cells.1,2,3 Angopho...		Apoptosis
T80996	Theasaponin E1
	Theasaponin E1 is a saponin derived from tea seeds, demonstrating antitumor potential in human tumor cell lines K562 and HL60. Additionally, it possesses quinone reductase (QR)-inducing activity, suggesting its efficacy ...
TN3528	Bonducellpin D		Antifection
	Bonducellpin D may show inhibitory activities on the Para3 virus. It also exhibits moderate activity against four tested human cancer cell lines, HepG-2, K562, HeLa, and Du145.		Antifection
TN4404	Ladanein		HCV Protease
	Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radicals DPPH and ABTS +.scavenging activity, it also displays m...		HCV Protease
T0194	Chloroquine phosphate	Chloroquine diphosphate,Aralen phosphate,Chingamin phosphate	SARS-CoV , TLR , HIV Protease , Antibiotic , Parasite , Autophagy
	Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T37543	Anhydroepiophiobolin A
	Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, an...
T37451	Stachybotrysin B
	Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cy...
T37008	Reveromycin A
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antip...
T38243	Hygrolidin
	Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC...
T1507	Streptozocin	STZ,Streptozotocin,NSC-85998,U 9889	DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy
	Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th...
TN2646	16-Hydroxycleroda-3,13-dien-15,16-olide		Autophagy
	16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-d...		Autophagy

Natural Products

Novobiocin Sodium

T0974

Synonym: Albamycinsodium,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

Astaxanthin

T3138

Synonym: β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin

Target: Reactive Oxygen Species, PPAR

Daunorubicin hydrochloride

T1511

Synonym: Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Fingolimod

T7939

Synonym: FTY-720A,FTY-720

Target: S1P Receptor, PAK, LPL Receptor

Tenacissoside I

T6S1843

Synonym: Tenacissimoside B

Target: Others

2-Desoxy-4-epi-pulchellin

TN2755

Synonym:

Target: Anti-infection

Silybin B

TN2211

Synonym: Silibinin B

Target: Apoptosis, Beta Amyloid, Bcr-Abl

Kirenol

T4S1943

Synonym: Kirel

Target: Wnt/beta-catenin

Paris saponin VII

T4085

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Icaritin

T3398

Synonym: Anhydroicaritin,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

Oroxylin A

T6S1315

Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Crebanine

T2S2215

Synonym:

Target: Apoptosis, Others, Akt

S-30-Hydroxygambogic acid

T81232

Synonym:

Target:

R-30-Hydroxygambogic acid

Synonym: 2,22-Hopanediol

Erythrodiol 3-palmitate

Quercetin 3-O-robinobioside

Target: Antifection, Immunology/Inflammation related

Norglaucine hydrochloride

Chloroquine phosphate

T0194

Synonym: Chloroquine diphosphate,Aralen phosphate,Chingamin phosphate

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Anhydroepiophiobolin A

Synonym: STZ,Streptozotocin,NSC-85998,U 9889

Target: DNA Alkylator/Crosslinker, DNA Alkylation, DNA/RNA Synthesis, Antibacterial, Antibiotic, Autophagy

16-Hydroxycleroda-3,13-dien-15,16-olide

TN2646

Synonym:

Target: Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01250	IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-01462	IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPH-01648	MED1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory...
TMPY-00304	IL-11R alpha/IL-11RA Protein, Canine, Recombinant (hFc)	Canine	HEK293
	Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-04097	IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His)	Canine	HEK293
	Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-03900	IL-11R alpha/IL-11RA Protein, Canine, Recombinant	Canine	HEK293
	Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...