glun1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T82297	GluN1(356-385)
	GluN1 (356-385) is an antigenic peptide implicated in N-methyl-D-aspartate receptor (NMDAR) encephalitis and has been shown to decrease the density of NMDAR surface clusters in hippocampal neurons. It serves as a tool to...
T82296	GluN1(359-378)
	GluN1 (359-378) is an antibody targeting the N-methyl-D-aspartate receptor (NMDAR) capable of crossing the blood-brain barrier and is utilized in researching therapies for anti-NMDAR encephalitis that focus on the immune...
T7870	TCN 201	TCN-201	NMDAR , iGluR
	TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.		NMDAR , iGluR
T16801	(RS)-(Tetrazol-5-yl)glycine	LY 285265,D,L-(tetrazol-5-yl)glycine	NMDAR , iGluR
	(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1...		NMDAR , iGluR
T15684	L-689560		NMDAR , iGluR
	L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in diseases. At the GluN1 glycine binding site, L-689560 is an...		NMDAR , iGluR
T10781	CGP 78608 hydrochloride	PAMQX	NMDAR , iGluR
	CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-...		NMDAR , iGluR
T8450	TCN 213	TCN213	NMDAR
	TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B		NMDAR
T1186L	Ifenprodil	RC 61-91,RC-61-91,RC61-91,RC 6191	Adrenergic Receptor , NMDAR
	Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibit...		Adrenergic Receptor , NMDAR
T19881	UBP608	UBP-608,UBP 608
	UBP608 is an allosteric modulator of NMDA receptor family. It selectively inhibits GluN1/GluN2A receptors with a 23-fold selectivity compared to GluN1/GluN2D receptors.
T24915	UBP618	UBP-618,UBP 618
	UBP618 is a GluN1/GluN2 receptors pan-inhibitor.
T69906	PEAQX sodium
	PEAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the K...
T24551	NSC339614 potassium	NSC 339614 potassium,NSC-339614 potassium,NSC339614 potassium salt
	NSC339614 potassium is a selective GluN1/GluN2C and GluN1/GluN2D receptors potentiator.
T24916	UBP646	UBP-646,UBP 646
	UBP646 is a GluN1/GluN2 receptors potentiator.
T24917	UBP684	UBP-684,UBP 684
	UBP684 is an NMDAR pan-PAM. UBP684 increases the maximal l-glutamate/glycine response while having minor subunit-specific effects on agonist potency. It robustly potentiates responses at all GluN1/GluN2 subtypes and at n...
T71290	EVT-101 HCl
	EVT-101 is a GluN2B antagonist, binding at the same GluN1/GluN2B dimer interface as ifenprodil but adopting a remarkably different binding mode involving a distinct subcavity and receptor interactions.
T62376	GNE-9278
	GNE-9278 is a highly selective NMDAR orthosteric modulator that acts on the GluN1 transmembrane structural domain (TMD).GNE-9278 acts on activated NMDAR and increases peak current and agonist affinity.
T61227	NAB-14
	NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compou...
T79569	AChE/Aβ-IN-1
	AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM...
T79571	AChE/Aβ-IN-2
	AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM. It also functions as an NMDA receptor antagonist (GluN1-1b/GluN2B subunit combination) with an IC50 of...