bcl6 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60008	BCL6-IN-6		BCL
	BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes.		BCL
T10487	BCL6-IN-3		BCL , Others , DNA
	BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.		BCL , Others , DNA
T36484	BCL6-IN-4	BCL6-IN-4
	BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1].
T39788	BCL6-IN-5	BCL6-IN-5
	BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.
T3940	CID5721353	BCL6 inhibitor	Apoptosis , BCL
	CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove.		Apoptosis , BCL
T8731	BCL6-IN-7
	BCL6-IN-7 is a potent BCL6 protein-protein interaction(PPI) inhibitor[1].
T14515	BCL6-IN-8c		Others
	BCL6-IN-8c is an orally active and potent inhibitor of B-cell lymphoma 6 (BCL6)-corepressor interaction(IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay).		Others
T73869	BCL6 PROTAC 1
	BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 value of 8.8 µM and significantly degrades BCL6 in diffuse large B-cell lymph...
T62854	BCL6-IN-9
	BCL6-IN-9 (compound 1) is a potent inhibitor of B-cell lymphoma 6 protein (BCL6) (IC50: 3.9 nM) and can be used to study cancer.
T14561	BI-3812		BCL
	BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity.		BCL
T5408	BI-3802		BCL
	BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependen...		BCL
T4089	FX1		Apoptosis , BCL
	FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).		Apoptosis , BCL
T4019	Cambinol	SIRT1/2 Inhibitor IV,NSC 112546	Apoptosis , Phospholipase , Sirtuin
	Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Ca...		Apoptosis , Phospholipase , Sirtuin
T75105	OICR12694 TFA
	OICR12694 (JNJ-65234637) TFA, an orally active B cell lymphoma 6 (BCL6) inhibitor [1], demonstrates effectiveness in targeting BCL6 pathways.
T78854	WK499
	BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage. It effectively hampers the proliferation of various AML ce...
T39697	Thalidomide-piperazine-Boc
	Thalidomide-piperazine-Boc is an intermediate utilized for synthesizing BCL6 PROTAC, which targets B-cell lymphoma 6 protein.
T63862	CCT373567
	CCT373567 is a potent degrader of the transcriptional repressor BCL6 (IC50: 2.9 nM) and exhibits anti-proliferative effects.
T63503	CCT369260
	CCT369260 (compound 1), an orally active inhibitor targeting B-cell lymphoma 6 (BCL6), demonstrates anti-tumor efficacy with an IC50 value of 520 nM [1].
T73333	OICR12694	JNJ-65234637
	OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6) .
TP1562	F1324
	F1324 is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6) with an IC50 of 1 nM. F1324 exhibits binding t1/2 value of 441 s and has strong inhibition activity against BCL6 PPI.
TP1797	F1324 TFA
	F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM.
T84316	ARV-393		PROTACs
	ARV-393 is a BCL6 PROTAC degrader with DC50 and GI50 values of <1 nM in both DLBCL and BL cell lines. ARV-393 inhibits tumor volume in multiple tumor xenograft models.		PROTACs
T78177	CCT374705
	CCT374705, an orally active BCL6 inhibitor, exhibits potent antiproliferative effects in vitro and effectively inhibits tumor growth in a lymphoma xenograft mouse model [1].
T79801	TCIP 1		Epigenetic Reader Domain
	TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL6 and BRD4. This compound facilitates cell death gene expre...		Epigenetic Reader Domain
T63861	CCT373566
	CCT373566 is a potent, orally active degrader of the transcriptional repressor BCL6 (IC50: 2.2 nM). CCT373566 exhibits significant anti-proliferative effects in vitro and reduces tumour growth in vivo.
T67949	TMX-2164
	TMX-2164, a potent and irreversible inhibitor of B-cell lymphoma 6 (BCL6), demonstrates an IC50 of 152 nM, indicating strong inhibitory efficacy. It exhibits prolonged target engagement and effectively inhibits cell prol...

Compounds

BCL6-IN-6

T60008

Target: BCL, Others, DNA

Synonym: BCL6 inhibitor

Target: Apoptosis, BCL

Target: Apoptosis, BCL

Cambinol

T4019

Synonym: SIRT1/2 Inhibitor IV,NSC 112546

Target: Apoptosis, Phospholipase, Sirtuin

Thalidomide-piperazine-Boc

Synonym: JNJ-65234637

Target: Epigenetic Reader Domain

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01000	BCL6 Protein, Human, Recombinant	Human	E. coli
	BCL6 Protein, Human, Recombinant is expressed in E. coli.
TMPH-00999	BCL6 Protein, Human, Recombinant (His)	Human	E. coli
	BCL6 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-02430	BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx)	Human	E. coli
	The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexe...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His)	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate...