aaa — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T35855	AAA
	AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-...
T40048	MC-AAA-NHCH2OCH2COOH	MC-AAA-NHCH2OCH2COOH
	MC-AAA-NHCH2OCH2COOH (compound 20) is a cleavable antibody-drug conjugate (ADC) linker. Its primary application lies in the synthesis of ADCs.
T40049	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), is a camptothecin payload which can be utilized in the synthesis of a camptothecin antibody-drug conjugate (ADC) by conjugation to a mono...
T63060	AAA-10
	AAA-10 is an orally active inhibitor of bile salt hydrolase (BSH) in B. intestinalis that acts on B. thetarBSH (IC50: 10 nM) and B. longumrBSH (IC50: 80 nM).
T63616	AAA-10 formic
	AAA-10 formic is an orally active inhibitor of intestinal bacterial bile salt hydrolase (BSH) against B. thetarBSH (IC50: 10 nM) and B. longumrBSH (IC50: 80 nM).
T8513	Spastazoline		Others
	Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).		Others
T9882	RUVBL1/2 ATPase-IN-1		Others
	RUVBL1/2 ATPase-IN-1 is an effective RUVBL1/2 ATPase inhibitor with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1/2 ATPase-IN-1 can be used in cancer disease studies.		Others
T6796	CB-5083	CB5083,CB 5083	p97
	CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).		p97
T83298	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT
	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT is a double-stranded ribonucleoside that is modified with the fluorescent molecule 5'6-FAM, a combination of 5-FAM and 6-FAM. The excitation/emission wavelengths of 5-F...
T60432	NAAA-IN-3
	NAAA-IN-3 (Compound 17a) is a potent and selective NAAA inhibitor with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanola...
T60378	NAAA-IN-2
	NAAA-IN-2 (Compound 9), a potent and selective inhibitor of NAAA, exhibits an IC50 of 50 nM. NAAA, a cysteine amidase, primarily breaks down the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OE...
T60767	NAAA-IN-1
	NAAA-IN-1 (Compound 1) can be used in the inflammation and pain research. NAAA-IN-1 is a potent and selective NAAA inhibitor (IC 50 = 7 nM). NAAA is a cysteine amidase. NAAA preferentially hydrolyzes the endogenous bioli...
T5425	ML367		Epigenetic Reader Domain
	ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and acts as a probe molecule that has low micromolar inhibitory activity		Epigenetic Reader Domain
T28506	Rbin-2		Phosphatase
	Rbin-2 is a cell-permeable, potent, selective and reversible inhibitor of Midasin (Mdn1).Rbin-2 directly targets the AAA+ ATPase Midasin and inhibits eukaryotic ribosome production, making it a potent probe for the study...		Phosphatase
T14965	Ciliobrevin D		ATPase , Hedgehog/Smoothened
	Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ...		ATPase , Hedgehog/Smoothened
T72043	SCFSkp2-IN-2		Apoptosis , E1/E2/E3 Enzyme
	SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells.		Apoptosis , E1/E2/E3 Enzyme
T9008	NPD8733		Others
	NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.		Others
T29068	UPCDC-30245	UPCDC 30245
	UPCDC30245 is an AAA ATPase p97 allosteric inhibitor.
T39008	PRMT5-IN-4	PRMT5-IN-4
	PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.
T12114	MSC1094308		p97
	MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase.		p97