1400w dihydrochloride

1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) is a highly effective and specific inhibitor of inducible NOS2 (iNOS).

Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1 2 4 6 (IC50=36 47 510 1400 nM). Romidepsin has antitumor activity and can be used for the treatment of peripheral T-cell lymphoma and cutaneous T-cell lymphoma.

DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a cell-permeable, stable free radical commonly used to evaluate the free radical scavenging ability, hydrogen donation capacity of compounds, and to measure the antioxidant activity of tissue extracts.

Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.

Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist.

Bevantolol hydrochloride (NC-1400 hydrochloride) is a β1-adrenoceptor antagonist that treatment angina pectoris and hypertension.

Pargolol hydrochloride is an antagonist of β adrenergic receptor.

Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (EC50: 6.0 μM).

LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), showing higher affinity for RARβ. It is highly selective over RARγ, RXRα, RXRβ, and RXRγ. LE135 also acts as a potent TRPV1 and TRPA1 receptor activator with EC50s of 2.5 μM and 20 μM, respectively.

KIN1400, a novel IRF3 activator, triggers IRF3-dependent innate immune antiviral genes and IFNbeta307 expression, suppresses WNV, DV infection, and HCV replication.

Ro 19-1400, a platelet-activating factor antagonist, directly inhibits immunoglobulin E-dependent mediator release.

Umbralisib (TGR 1202) is a PI3Kδ inhibitor.

Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies.

Umbralisib (TGR-1202) sulfate, an orally active compound, serves as a potent, selective inhibitor targeting both PI3Kδ and casein kinase-1-ε (CK1ε), with EC50 values of 22.2 nM and 6.0 μM, respectively. It demonstrates unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL) and is applicable in the research of hematological malignancies.

HDAC6-IN-17 (compound 5b) is a potent HDAC6 inhibitor with IC50 values of 150 nM for HDAC6, 1400 nM for HDAC8, and 2300 nM for HDAC4, demonstrating cytotoxic activity against human cancer cell lines and being utilized in cancer research [1].

PVA (Mw 67000, 87-89% hydrolyzed, ～1400 polymerization) is a form of polyvinyl alcohol with a molecular weight of 67000 and hydrolytic properties. The degree of hydrolysis indicates the rate at which acetate groups in the original polyvinyl acetate are converted to hydroxyl groups. This PVA is obtained by polymerizing vinyl acetate and subsequently removing the acetate groups through hydrolysis. Polyvinyl alcohols with varying degrees of hydrolysis can be used in self-crosslinking to form freeze gels, which are utilized as biological excipients.

PVA (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization) (Polyvinyl alcohol; Poly(Ethenol)) is a biodegradable polymer. It is utilized in the production of biocomposite films.

Sodium carboxymethyl cellulose (Viscosity: 1200-1400 mPa.s) is the sodium salt of carboxymethyl cellulose and is commonly employed as a thickening agent, paste, and barrier agent.