β-glucan

Lentinan, isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.

Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers.

Enfumafungin is a triterpenoid glycoside isolated from endophytic fungi, exhibiting antifungal activity against Candida and Aspergillus species by inhibiting (1,3)-β-D-glucan synthesis.

Fusacandin B inhibits (1,3)-β-glucan synthase and possesses antifungal properties.

Fusacandin A inhibits (1,3)-β-glucan synthase and exhibits antifungal properties.

Pneumocandin A1 is a lipopeptide antibiotic with potent anti-candidal activity. It inhibits 1,3-β-glucan synthesis in vitro, with an IC50 range of 0.07-0.5 μg/mL.

Pneumocandin A4 is a lipopeptide antibiotic with potent activity against Candida species. It inhibits 1,3-β-D-glucan synthesis in vitro, with an IC50 ranging from 0.07 to 0.5 μg/mL.

Arborcandin D is a 1,3-β-glucan synthase inhibitor that functions as an antifungal antibiotic. It exhibits IC50 values of 3 μg/mL against Candida albicans (C. albicans) and 0.35 μg/mL against Aspergillus fumigatus (A. fumigatus). The minimum inhibitory concentration (MIC) of Arborcandin D for Candida species is 4 μg/mL.

Arborcandin B is an inhibitor of 1,3-β-glucan synthase and serves as an antifungal antibiotic. The IC50 values of Arborcandin B for Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus) are 0.30 μg/mL and 0.025 μg/mL, respectively. The minimum inhibitory concentration (MIC) for Candida species is 2-4 μg/mL.

Arborcandin F, a 1,3-β-glucan synthase inhibitor, serves as an antifungal antibiotic. It exhibits IC50 values of 0.012 μg/mL against Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus). For Candida species, the minimum inhibitory concentration (MIC) of Arborcandin F ranges from 0.25 to 1 μg/mL.

Arborcandin E is a 1,3-β-glucan synthase inhibitor used as an antifungal antibiotic. It exhibits IC50 values of 0.1 μg/mL against Candida albicans (C. albicans) and 0.012 μg/mL against Aspergillus fumigatus (A. fumigatus). Additionally, Arborcandin E has a MIC of 0.5-2 μg/mL for Candida species.

Arborcandin A is a 1,3-β-glucan synthase inhibitor, acting as an antifungal antibiotic. It exhibits IC50 values of 0.25 μg/mL against Candida albicans (C. albicans) and 0.05 μg/mL against Aspergillus fumigatus (A. fumigatus). The MIC for the Candida species is 4-8 μg/mL.

Arborcandin C is an inhibitor of 1,3-β-glucan synthase, functioning as an antifungal antibiotic. It exhibits IC50 values of 0.15 μg/mL against Candida albicans (C. albicans) and 0.015 μg/mL against Aspergillus fumigatus (A. fumigatus). The compound's minimum inhibitory concentration (MIC) for Candida species ranges from 1-2 μg/mL.