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Protease substrates

Protease substrate dyes are compounds designed specifically for detecting protease activity. They are usually composed of a peptide segment that can be recognized and cleaved by a specific protease and a chromogenic or fluorophore. When the protease acts on the substrate, a chromogenic or fluorescent signal is released, thereby achieving quantitative analysis of protease activity. This type of dye is widely used in intracellular protease activity research, drug screening, and disease diagnosis.

X-GAL
T190757240-90-6
X-GAL (BCIG) is a widely used chromogenic substrate for β-galactosidase, which cleaves X-GAL to produce an insoluble blue compound.
  • $59
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4-MUNANA
T3812076204-02-9
4-MUNANA is a fluorescent substrate employed in neuraminidase activity assays and serves as a neuraminidase substrate analogue.
  • $31
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ABTS diammonium salt
T1890830931-67-0
ABTS diammonium salt (AzBTS-(NH4)2) is used as a substrate for horseradish peroxidase (HRP) conjugate.
  • $35
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Boc-Gln-Ala-Arg-AMC hydrochloride
T74040201849-55-0
Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorescent compound used as a substrate for trypsin and for assessing the protein hydrolysis activity of TMPRSS2.
  • $47
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BCIP
T189236578-06-9
BCIP (BCIP p-toluidine salt) (BCIP p-toluidine salt) is an artificial chromogenic substrate. It is used for the sensitive colorimetric detection of alkaline phosphatase activity.
  • $85
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Z-IETD-AFC
T36333219138-02-0
Z-IETD-AFC is a fluorescent substrate for caspase-8 and granzyme B. It can be used to quantify cysteinyl aspartate-8 or granzyme B activity.
  • $60
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Dansylcadaverine
T1896810121-91-2
Dansylcadaverine (Monodansyl cadaverine) is a fluorescent probe.
  • $29
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4-Methylumbelliferyl-β-D-glucuronide hydrate
T18887881005-91-0
4-Methylumbelliferyl-β-D-glucuronide hydrate (MUG) is a fluorogenic substrate (λex=362 nm, λem=445 nm).
  • $39
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BCDA
T188803252-36-6
BCDA (5-bromo-4-chloroindoxyl acetate) is a chromogenic substrate utilized to detect esterase activity.
  • $30
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Msr-Ratio
T398172290635-22-0In house
Msr-Ratio (Msr-green) (Msr-green) is a ratiometric fluorescent probe specifically designed for the detection of methionine sulfoxide reductase (MSR) activity. It has an excitation wavelength of 375 nm and an emission wavelength of 550 nm. This probe offers the ability to monitor the enzyme activity both in vitro and in live cells, making it a valuable tool for studying MSR function.
  • $31
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Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2
T370251926163-82-7
Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Upon cleavage by MMP-14, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation emission maxima of 328 420 nm, respectively.
  • TBD
35 days
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Mca-PLGL-Dpa-AR-NH2
T762671135689-33-6
Mca-PLGL-Dpa-AR-NH2 is a fluorescent peptide MMP substrate [1] .
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Mca-Ala-Pro-Lys(Dnp)-OH
T40384305336-82-7
Mca-Ala-Pro-Lys(Dnp)-OH, a specific quenched fluorogenic substrate for ACE2, enables the detection of ACE2 activity in various tissues, including urinary, heart, and lung.
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    Fast Green free acid
    T3174925738-40-3
    Fast Green free acid is a dye that resists acid once applied.
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    Z-Arg-Arg-4MβNA triacetate
    T75367100900-19-4
    Z-Arg-Arg-4MβNA triacetate serves as a specific substrate for cathepsin B, producing the fluorescent product 4MβNA, which has an excitation wavelength (λ ex) of 355 nm and an emission wavelength (λ em) of 430 nm [1] [2].
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    3-6 months
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    TFMU-ADPr
    T745102412923-11-4
    TFMU-ADPr serves as a versatile substrate for assessing poly(ADP-ribose) glycohydrolase (PARG) activity, enabling direct measurement of total PAR hydrolase activity through the liberation of a fluorophore. Exhibiting exceptional reactivity, generality, stability, and usability, TFMU-ADPr is an effective tool for evaluating small-molecule inhibitors and investigating the regulation of ADP-ribosyl catabolic enzymes in vitro [1].
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    DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS
    T75369263718-22-5
    DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye used as a fluorogenic substrate for aspartyl proteinase from the human malaria parasite [1]. It should be stored protected from light.
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    3-6 months
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    D-Ala-Lys-AMCA
    T18959375822-19-8
    D-Ala-Lys-AMCA, a known substrate of proton-coupled oligopeptide transporter 1 (PEPT1), emits blue fluorescence and may be transported into Caco-2 cells and liver cancer cells.
    • $1,670
    8-10 weeks
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    Mca-YVADAP-Lys(Dnp)-OH
    T76090189696-01-3
    Mca-YVADAP-Lys(Dnp)-OH serves as a fluorogenic substrate specifically for caspase-1 and angiotensin-converting enzyme 2 (ACE2) [1].
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    Z-DEVD-AMC
    T76232
    Z-DEVD-AMC is a selective substrate for caspase-3, measurable through fluorescence spectrometry, and serves as a fluorescence reference standard for AMC-based enzyme substrates, including those for caspase [1].
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    Dnp-PLGLWA-DArg-NH2 TFA
    T76269
    Dnp-PLGLWA-DArg-NH2 TFA, a fluorogenic substrate specifically for MMP-1 and MMP-9, facilitates the quantification of MMP activity at an excitation wavelength of 280 nm and an emission wavelength of 360 nm [1] [2].
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    L-Leucine-7-amido-4-methylcoumarin hydrochloride
    T3706262480-44-8
    L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase.1Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation emission maxima of 340-360 440-460 nm, respectively. 1.Izquierdo, M., Lin, D., O'Neill, S., et al.Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using rapidfire mass spectrometrySLAS Discov.25(9)1064-1071(2020)
    • $135
    7-10 days
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    CUG
    T1893764664-99-9
    CUG is a fluorogenic substrate (λex=386, λem=445 nm, ε=32K).
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      Z-(L-Arg)-AMC (hydrochloride)
      T3705370375-22-3
      Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation emission maxima of 340-360 440-460 nm, respectively. 1.Zimmerman, M., Ashe, B., Yurewicz, E.C., et al.Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substratesAnal. Biochem.78(1)47-51(1977) 2.Brindley, P.J., Kalinna, B.H., Dalton, J.P., et al.Proteolytic degradation of host hemoglobin by schistosomesMol. Biochem. Parasitol.89(1)1-9(1997)
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