Mitochondria

MitoSOX Red is a novel fluorescent probe that is specific and cell membrane-permeable and targets mitochondria in living cells.MitoSOX Red is oxidized by superoxide upon entry into the mitochondria and is not oxidized by other ROS or RNS-generating systems.MitoSOX Red then binds to nucleic acids in the mitochondrion and produces a strong red fluorescence.MitoSOX Red can be used as a fluorescent indicator for the specific detection of superoxide.MitoSOX Red can be used as a fluorescent indicator for the specific detection of superoxide. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. Superoxide dismutase (SOD) prevents the oxidation of MitoSOX Red.

Rhodamine 123 is a fluorescent dye (λex=503 nm, λem=527 nm).

MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability to inhibit members of the Hsp70 family of molecular chaperones.

TMRE (Tetramethylrhodamine ethyl ester perchlorate) is a mitochondria specific dye (λex: 550 nm, λem: 575 nm).

Rhodamine 800 is a near-infrared fluorescent dye.

Rhodamine 6G (Basic Red 1) is a rhodamine analog useful in Pgp efflux assays. It can be widely used in characterizing the kinetics of MRP1- mediated efflux as a laser dye and potential mitochondrial probe.

2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.

Rhod-2 AM is a fluorescent probe of the mitochondrion with λex of 552 nm and λem of 581 nm.

TMRM is a cell-permeant cationic lipophilic red fluorescent dye (λex: 530 nm, λem: 592 nm).

FIM-1, a fluorescent probe for protein kinase C (PKC), facilitates mitochondrial staining and serves as an ATP-competitive inhibitor at the catalytic site of PKC, effectively inhibiting its activity [1].

Rhodamine 700 is an organic perchlorate salt and has a role as a fluorochrome.

MitoMark Green I is a green fluorescent mitochondrial stain [λmax ~ 490 516 nm].

HKSOX-1m (5 6-mixture) is a mitochondria-targeting O2 fluorescent probe with excitation emission wavelengths of 509 534 nm (green), offering exceptional selectivity and sensitivity for O2 across a wide pH range and in the presence of strong oxidants and prevalent reductants within cells.

HKSOX-1m hydrobromide (5 6-mixture), a mitochondria-targeted O2•− fluorescent probe (Ex Em=509 534nm; green), demonstrates exceptional selectivity and sensitivity for O2•− across a wide pH spectrum, robustly distinguishing it from strong oxidants and prevalent cellular reductants [1].

Acridine Orange 10-Nonyl Bromide is a cardiolipin fluorescent probe (λex: 489 nm, λem: 525 nm).

Janus green B is an agent of basic dye.

Mito-TRFS is the first off-on probe for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells.

MitoPerOx is a ratiometric fluorescent probe that can be used to assess changes in lipid peroxidation within mitochondria. It is composed of a BODIPY fluorophore conjugated via a dienyl link to a triphenylphosphonium cation component that drives its accumulation in mitochondria. MitoPerOx displays an excitation maximum of 495 nm and exhibits a shift in emission maxima from 590 to 520 nm upon mitochondrial lipid peroxidation, enabling determination of ratiometric measurements of lipid peroxidation in live cells.

3,3'-Dihexyloxacarbocyanine iodide (DiOC6(3)) is a carbocyanine dye used to monitor changes in mitochondrial membrane potential.