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cGAS

Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. It is part of the cGAS-STING DNA sensing pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis. cGAMP then functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production. Mice lacking cGAS are more vulnerable to lethal infection by DNA viruses and RNA viruses. In addition, cGAS has been shown to be an innate immune sensor of retroviruses including HIV. The human gene encoding cGAS is MB21D1 on chromosome 6.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T10065 2',3'-cGAMP 1441190-66-4 98%
2',3'-cGAMP
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3...
T10065L 2',3'-cGAMP sodium 2734858-36-5 99.71%
2',3'-cGAMP sodium
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding co...
T11673 IRAK4-IN-4 1850276-58-2 99.13%
IRAK4-IN-4
IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhib...
T12432 PF-06928215 2378173-15-8 98.73%
PF-06928215
PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ).
T9213 G140 2369751-07-3 98.16%
G140
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS).
T5486 RU.521 2262452-06-0 98%
RU.521
RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
T11344 G150 2369751-30-2 97.39%
G150
G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase...
2',3'-cGAMP
T10065
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3...
2',3'-cGAMP sodium
T10065L
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding co...
IRAK4-IN-4
T11673
IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhib...
PF-06928215
T12432
PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ).
G140
T9213
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS).
RU.521
T5486
RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
G150
T11344
G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase...
TargetMol