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Serotonin Transporter

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports serotonin from the synaptic cleft back to the presynaptic neuron.

  • Fluoxetine hydrochloride
    T0450L56296-78-7
    Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
    • $48
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  • Dapoxetine hydrochloride
    T6461129938-20-1
    Dapoxetine hydrochloride (LY-210448 hydrochloride) is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation.
    • $30
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  • Vilazodone
    T1279163521-12-8
    Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from the synaptic cleft while stimulating the release of 5-HT into the synaptic cleft. This increases the concentration of 5-HT in the synaptic cleft and potentiates serotonergic neurotransmission in the central nervous system.
    • $54
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  • PF-00217830
    T24613846032-02-8In house
    PF-00217830 is a serotonin 1A receptor agonist, dopamine D2 receptor agonist, and serotonin 2A receptor antagonist.PF-00217830 may be used in the study of schizophrenia.
    • $143
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  • MAO-B-IN-9
    T606712416910-88-6
    MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence. MAO-B-IN-9 has neuroprotective effects against Aβ1-42-induced neuronal cell death, which may be related to the anti-aggregation effect of Aβ1-42.
    • $195
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    TargetMol | Inhibitor Sale
  • Tedatioxetine
    T34795508233-95-2In house
    Tedatioxetine (Lu AA24530) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with antidepressant properties.Tedatioxetine acts as a CYP2D6 substrate.
    • $293
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  • WAY-260022
    T23711850692-43-2
    WAY-260022 is an orally available and selective norepinephrine transporter protein inhibitor that displays inhibitory effects on serotonin and dopamine transporter proteins.
    • $293
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  • Nitroxazepine
    T1223247439-36-1
    Nitroxazepine (CIBA 2330Go) is a serotonin-norepinephrine reuptake inhibitor, and treatment depression. Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression
    • $79
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  • Azaphen
    T752124853-80-3
    Azaphen (Pipofezin hydrochloride) is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity.
    • $135
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  • Clovoxamine
    T2704754739-19-4In house
    Clovoxamine (DU 23811) is a 5-hydroxytryptamine reuptake, serotonin and norepinephrine inhibitor with antidepressant and anticonvulsant activity.
    • $293
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  • Desipramine hydrochloride
    T099158-28-6
    Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.
    • $35
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    TargetMol | Citations Cited
  • Venlafaxine
    T2245393413-69-5
    Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia.
    • $32
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  • Fluoxetine
    T045054910-89-3
    Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.
    • $30
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  • Imipramine hydrochloride
    T7941113-52-0
    Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion
    • $53
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  • Paroxetine hydrochloride
    T163678246-49-8
    Paroxetine hydrochloride (Paroxetine HCl) is a serotonin uptake inhibitor that is effective in the treatment of depression.
    • $45
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  • Sertraline hydrochloride
    T048279559-97-0
    Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.
    • $47
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  • Centanafadine hydrochloride
    T10758L923981-14-0
    Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).
    • $54
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  • Paroxetine
    T870861869-08-7
    Paroxetine is a inhibitor of serotonin uptake that is effective in the treatment of depression.
    • $30
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  • Vortioxetine hydrobromide
    T2395L960203-27-4
    Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).
    • $43
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  • Deschloroclozapine
    T110781977-07-7
    Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
    • $50
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  • Milnacipran hydrochloride
    T1189101152-94-7
    Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromyalgia. Milnacipran hydrochloride and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice.
    • $31
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  • DL-Tryptophan
    TN228554-12-6
    DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment.
    • $30
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  • Dasotraline hydrochloride
    T3526675126-08-6
    Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
    • $41
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  • Fluvoxamine maleate
    T107761718-82-9
    Fluvoxamine maleate (DU-23000 (maleate)) is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.
    • $47
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  • Dextromilnacipran
    T259496847-55-1
    Dextromilnacipran (Levomilnacipran) is a selective serotonin and norepinephrine reuptake inhibitor.
    • $45
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  • DOV-216,303 Free Base
    T1108766504-40-3
    DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.
    • $135
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  • Phenelzine
    T954051-71-8
    Phenelzine is an antidepressant and mania drug, which is a monoamine oxidase inhibitor. Its antidepressant effect is similar to that of niacinamide. It can reduce the degradation of catecholamines (norepinephrine, dopamine, and serotonin) in the brain and increase the content of catecholamines. , and play an antidepressant effect. It has a good effect on endogenous depression but has a poor effect on exogenous and reactive depression.
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  • Cinchonidine
    T1317485-71-2
    Cinchonidine (L-Cinchonidine) is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine.
    • $31
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  • Desvenlafaxine succinate hydrate
    T6188386750-22-7
    Desvenlafaxine succinate hydrate (WY 45233 Succinate) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
    • $35
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  • Desvenlafaxine
    T158093413-62-8
    Desvenlafaxine (O-Desmethylvenlafaxine) is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an antidepressive agent.
    • $89
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  • Amitriptyline hydrochloride
    T0678549-18-8
    Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
    • $45
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  • Duloxetine
    T7061116539-59-4
    Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.
    • $40
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  • Vilazodone Hydrochloride
    T6232163521-08-2
    Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.
    • $40
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  • Duloxetine hydrochloride
    T1471136434-34-9
    Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.
    • $48
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  • Escitalopram Oxalate
    T6493219861-08-2
    Escitalopram Oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
    • $33
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  • Citalopram hydrobromide
    T148359729-32-7
    Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). Citalopram hydrobromide is the orally bioavailable hydrobromide salt of the racemic bicyclic phthalene derivative citalopram with antidepressant activity. This agent has minimal effects on the CNS neuronal reuptake of norepinephrine (NE) and dopamine (DA).
    • $40
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    TargetMol | Citations Cited
  • Clomipramine hydrochloride
    T025517321-77-6
    Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
    • $32
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  • Venlafaxine hydrochloride
    T047299300-78-4
    Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
    • $32
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  • Escitalopram
    T0185128196-01-0
    Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
    • $41
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  • Gentisein
    T19931529-49-7
    Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7 µM[1][2].
    • $51
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  • Vortioxetine
    T2395508233-74-7
    Vortioxetine (Lu AA 21004) is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment.
    • $43
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  • ZZL-7
    T6431799141-91-0
    ZZL-7 is a fast-onset antidepressant agent. ZZL-7 disrupts the interaction between the neuronal nitric oxide synthase (nNOS) and serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the blood-brain barrier readily. ZZL-7 has research value in major depressive disorder (MDD).
    • $47
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  • (Z)-Thiothixene
    T134583313-26-6
    (Z)-Thiothixene (Thiothixene) is an antagonist of serotonergic receptor.
    • $37
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  • Milnacipran ((1S-cis) hydrochloride)
    T7940175131-60-9
    Milnacipran (1S-cis) hydrochloride (Levomilnacipran Hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI), treatment of fibromyalgia.
    • $31
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  • Amitifadine hydrochloride
    T2092410074-74-7
    Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
    • $97
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  • Ketanserin tartrate
    T1066L83846-83-7
    Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist with antihypertensive activity, inhibits serotonin-induced vasoconstriction and platelet activation, and can be used in the study of systemic sclerosis.
    • $31
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