Na+/Ca2+ Exchanger

The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). A single calcium ion is exported for the import of three sodium ions.[1] The exchanger exists in many different cell types and animal species. The NCX is considered one of the most important cellular mechanisms for removing Ca2+. The exchanger is usually found in the plasma membranes and the mitochondria and endoplasmic reticulum of excitable cells.

Cat. No.	Product name	CAS No.	Purity
T11319	FR183998 free base	239440-20-1	98%
FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
T5457	SN 6	415697-08-4	98%
SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)
T6144	KB-R7943 mesylate	182004-65-5	99.22%
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM.
T3508	SEA0400	223104-29-8	99.29%
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.
T5850	Benzamil	2898-76-2	99.3%
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane ...
T1266	Terfenadine	50679-08-8	99.75%
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...
T14941	CGP37157	75450-34-9	98%
CGP37157 is an inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria (IC50: 0.8 μM).

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T11319

FR183998 free base

239440-20-1

98%

FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.

T5457

SN 6

415697-08-4

98%

SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)

T6144

KB-R7943 mesylate

182004-65-5

99.22%

KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM.

T3508

SEA0400

223104-29-8

99.29%

SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.

T5850

Benzamil

2898-76-2

99.3%

Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane ...

T1266

Terfenadine

50679-08-8

99.75%

Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...

T14941

CGP37157

75450-34-9

98%

CGP37157 is an inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria (IC50: 0.8 μM).