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Na+/Ca2+ Exchanger

The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). A single calcium ion is exported for the import of three sodium ions.[1] The exchanger exists in many different cell types and animal species. The NCX is considered one of the most important cellular mechanisms for removing Ca2+. The exchanger is usually found in the plasma membranes and the mitochondria and endoplasmic reticulum of excitable cells.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T16897 SM-6586 103898-38-0 99.43%
SM-6586
SM-6586 is a potent calcium channel antagonist with inhibitory effects on Na+/H+ and Na+/Ca2+ exchange channels, and can be used in the study of cerebrovascular ...
T1266 Terfenadine 50679-08-8 99.36%
Terfenadine
Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist...
T5850 Benzamil 2898-76-2 99.3%
Benzamil
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane ...
T14941 CGP37157 75450-34-9 99.04%
CGP37157
CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitoch...
T6144 KB-R7943 mesylate 182004-65-5 98%
KB-R7943 mesylate
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM.
T5457 SN 6 415697-08-4 98%
SN 6
SN 6 (SN6) is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)
T3508 SEA0400 223104-29-8
SEA0400
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.
T11319 FR183998 free base 239440-20-1 98%
FR183998 free base
FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
T16564 PPADS tetrasodium 192575-19-2 98%
PPADS tetrasodium
PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprote...
SM-6586
T16897
SM-6586 is a potent calcium channel antagonist with inhibitory effects on Na+/H+ and Na+/Ca2+ exchange channels, and can be used in the study of cerebrovascular ...
Terfenadine
T1266
Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist...
Benzamil
T5850
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane ...
CGP37157
T14941
CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitoch...
KB-R7943 mesylate
T6144
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM.
SN 6
T5457
SN 6 (SN6) is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)
SEA0400
T3508
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.
FR183998 free base
T11319
FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
PPADS tetrasodium
T16564
PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprote...
TargetMol