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Na+/Ca2+ Exchanger

The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). A single calcium ion is exported for the import of three sodium ions.[1] The exchanger exists in many different cell types and animal species. The NCX is considered one of the most important cellular mechanisms for removing Ca2+. The exchanger is usually found in the plasma membranes and the mitochondria and endoplasmic reticulum of excitable cells.
Cat. No. Product name CAS No. Purity Chemical Structure
T11319 FR183998 free base 239440-20-1 98%
FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
T5457 SN 6 415697-08-4 98%
SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)
T14941 CGP37157 75450-34-9 98%
CGP37157 is an inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria (IC50: 0.8 μM).
T6144 KB-R7943 mesylate 182004-65-5 98%
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM.
T3508 SEA0400 223104-29-8 98%
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.
T5850 Benzamil 2898-76-2 98%
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane ...
T1266 Terfenadine 50679-08-8 98%
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...
FR183998 free base
T11319
FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
SN 6
T5457
SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)
CGP37157
T14941
CGP37157 is an inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria (IC50: 0.8 μM).
KB-R7943 mesylate
T6144
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM.
SEA0400
T3508
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.
Benzamil
T5850
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane ...
Terfenadine
T1266
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...