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MyD88

MyD88 (Myeloid differentiation primary response gene 88) is a protein that is encoded by the MYD88 gene in humans. Available evidence suggests that MYD88 is dispensable for human resistance to common viral infections and to all but a few pyogenic bacterial infections, demonstrating a major difference between mouse and human immune responses. MyD88 is an essential adaptor protein in the IL-1R1 signaling pathway. MyD88 may define a family of signal transduction molecules with an ancestral function in the activation of the immune system. MyD88 functions as a pure adaptor linking the IL-1R1 to downstream IRAK kinases. Mutation in MYD88 at position 265 leading to a change from leucine to proline have been identified in many human lymphomas including ABC subtype of Diffuse Large B-cell Lymphoma and Waldenstrom's Macroglobulinemia.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T27034 CL075 256922-53-9 98%
CL075
CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to e...
T3898 Schaftoside 51938-32-0 99.32%
Schaftoside
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T13063 T6167923 2437475-16-4 99.23%
T6167923
T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrup...
T41142 EM 163 1206480-93-4 99.07%
EM 163
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR stru...
T13932 TLR1 566914-00-9 98.51%
TLR1
TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.
T9765 TJ-M2010-5 1357471-57-8 97.01%
TJ-M2010-5
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myoca...
T77353 MyD88-IN-1 2911609-80-6 100%
MyD88-IN-1
MyD88-IN-1 is a potent MyD88 inhibitor MyD88-IN-1 has anti-inflammatory activity and inhibits downstream inflammatory signaling pathways, including the NF-κB pat...
CL075
T27034
CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to e...
Schaftoside
T3898
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T6167923
T13063
T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrup...
EM 163
T41142
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR stru...
TLR1
T13932
TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.
TJ-M2010-5
T9765
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myoca...
MyD88-IN-1
T77353
MyD88-IN-1 is a potent MyD88 inhibitor MyD88-IN-1 has anti-inflammatory activity and inhibits downstream inflammatory signaling pathways, including the NF-κB pat...
TargetMol