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TargetMol | Tags Apoptosis
TargetMol | Tags Autophagy
TargetMol | Tags Immunology/Inflammation

FKBP

The FKBPs, or FK506 binding proteins, constitute a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino acid sequence. FKBPs have been identified in many eukaryotes, ranging from yeast to humans, and function as protein folding chaperones for proteins containing proline residues. Along with cyclophilin, FKBPs belong to the immunophilin family.

FilterSignaling PathwaysImmunology/Inflammation-Autophagy-ApoptosisFKBP
  • SAFit2
    T168361643125-33-0In house
    SAFit2 is a highly effective and selective fk506 binding protein 51(FKBP51) inhibitor (Ki: 6 nM). SAFit2 can enhance AKT2-AS160 binding and participate in the downstream response of glucocorticoid release in vivo, and is a candidate compound for the treatment of obesity, chronic pain, depression and anxiety.
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    TargetMol | Inhibitor Hot
  • FKBP51F67V-selective antagonist Ligand2
    T791841680228-76-5
    FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or FKBP52 [1]. It effectively reverses the anxiogenic phenotype resulting from FKBP51 F67V overexpression in the amygdala.
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