β-glucuronidase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13477	β-Glucuronidase-IN-1		Antibacterial
	β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuron...		Antibacterial
T63250	β-Glucuronidase-IN-2
	β-Glucuronidase-IN-2 is a potent inhibitor of E. coli β-glucuronidase β-glucuronidase (IC50: 0.24 μM, Ki: 1.09 μM) and exhibits anti-proliferative effects with potential for anti-cancer and anti-inflammatory therapeutic ...
T63805	β-Glucuronidase/hCAII-IN-1
	β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50 values of 440.1 μM and 4.91 μM, respectively [1].
T63789	β-Glucuronidase/hCAII-IN-2
	β-Glucuronidase/hCAII-IN-2 is a potent inhibitor of β-glucuronidase and hCA II, and their IC50 values were 670.7 μM and 21.77 μM, respectively.
T37811	6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt)		Others
	6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) can be used in the histochemical analysis of β-glu...		Others
T41319	D-Saccharic acid 1,4-lactone hydrate		Others
	D-Saccharic acid 1,4-lactone hydrate is a potent β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2].		Others
T15422	GSK-626616		DYRK
	GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.		DYRK
T75363	Fluorescein Di-β-D-Glucuronide
	Fluorescein Di-β-D-Glucuronide, a fluorescent probe, enables non-invasive imaging of intestinal bacterial β-glucuronidase activity in nude mice. This compound's utilization for both in vitro and in vivo imaging offers va...
T78428	X-Gluc cyclohexanamine
	X-Gluc cyclohexanamine is a dye used to detect β-glucuronidase (GUS) activity and is commonly used as a marker for gene expression, which can be used to detect the expression of target genes.
T63908	HCAII-IN-4
	hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM. Additionally, it demonstrates inhibition of β-glucuronidase, presenting a...
T72259	3-Chlorogentisyl alcohol
	3-Chlorogentisyl alcohol, characterized by its potent inhibitory action against E. coli β-glucuronidase with an IC(50) value of 0.74 µM and a K(i) value of 0.58 µM, demonstrates significant antiproliferative activity. Th...
T19076	X-Gluc Dicyclohexylamine	5-Bromo-4-chloro-3-indolyl-beta-D-glucuronide cyclohexylammonium salt	Others
	X-Gluc Dicyclohexylamine (5-Bromo-4-chloro-3-indolyl-beta-D-glucuronide cyclohexylammonium salt) is a reagent to detect β-glucuronidase and can be used in molecular biology experiments to mark and select the expression o...		Others
T80692	β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE
	β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20), an auristatins-glucuronide conjugate, exhibits in vitro antiproliferative effects on cancer cells, both β-glucuronidase pretreated and untreated, with an IC50 ...
T36623	Antileukinate
	Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutro...
T36367	RK-682 (calcium salt)
	Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to th...
T15204	EHT 1610	EHT 5372	GSK-3 , NF-κB , Tyrosinase , DYRK , CDK
	EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, regulating cell cycle and inducing cell apoptosis...		GSK-3 , NF-κB , Tyrosinase , DYRK , CDK
T7390	DMAT	Casein kinase II Inhibitor,CK2 Inhibitor	Casein Kinase
	DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).		Casein Kinase

Compounds

β-Glucuronidase-IN-1

T13477

Synonym:

Target: Antibacterial

β-Glucuronidase-IN-2

T63250

Synonym:

Target:

β-Glucuronidase/hCAII-IN-1

T63805

Synonym:

Target:

β-Glucuronidase/hCAII-IN-2

T63789

Synonym:

Target:

6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt)

T37811

Synonym:

Target: Others

D-Saccharic acid 1,4-lactone hydrate

Fluorescein Di-β-D-Glucuronide

T75363

Synonym:

Target:

X-Gluc cyclohexanamine

3-Chlorogentisyl alcohol

T72259

Synonym:

Target:

X-Gluc Dicyclohexylamine

T19076

Synonym: 5-Bromo-4-chloro-3-indolyl-beta-D-glucuronide cyclohexylammonium salt

Target: Others

β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE

RK-682 (calcium salt)

Target: GSK-3, NF-κB, Tyrosinase, DYRK, CDK

DMAT

T7390

Synonym: Casein kinase II Inhibitor,CK2 Inhibitor

Target: Casein Kinase

Cat No.	Product Name	Synonyms	Targets
TN1818	Kaempferol 3-O-β-D-glucuronide	Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,Kaempferol-3-glucuronide	IL Receptor
	Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide)e has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells.		IL Receptor
TN7224	2,2'-Dihydroxy chalcone		Antibacterial , Autophagy
	2,2'-Dihydroxy chalcone is a potent inhibitor of β-glucuronidase (IC50=1.6±0.2 μM) and lysozyme (IC50=1.4±0.2 μM) release from rat neutrophils stimulated with fMLP/CB.2,2'-Dihydroxy chalcone has inhibitory activity again...		Antibacterial , Autophagy
T13716	(+)-Guaiacin		Others
	(+)-Guaiacin is a compound isolated from the bark of Machilus wangchiana Chun. It shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-act...		Others
TN2766	2'-Hydroxydaidzein		Cannabinoid Receptor , Antioxidant
	2'-Hydroxydaidzein is an isoflavonoid phytonutrient found in plant species, when a natural compound. 2'-Hydroxydaidzein has antioxidant activity, driven mainly by o-hydrogen bond dissociation enthalpy (BDE) and hydrogen ...		Cannabinoid Receptor , Antioxidant
TN1847	Kushenol X		Others
	Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).		Others

Natural Products

Kaempferol 3-O-β-D-glucuronide

TN1818

Synonym: Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,Kaempferol-3-glucuronide

Target: IL Receptor

2,2'-Dihydroxy chalcone

TN7224

Synonym:

Target: Antibacterial, Autophagy

Target: Cannabinoid Receptor, Antioxidant

Cat No.	Product Name	Species	Expression System
TMPJ-00787	GUSB Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Beta-D-glucuronidase from E.coli is a highly specific enzyme in hydrolyzing glucuronides. Beta-D-glucuronidase (GLUase) activity can be measured as the rate of production of fluorescent methylumbelliferone (MU), resulti...

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Targets

Compounds

Natural Products

Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins