y-15

Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.

7-Acetoxy-15-methoxy-10-O-methyldihydrobotrydial is a useful organic compound for research related to life sciences. The catalog number is T125441 and the CAS number is 196796-12-0.

MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP TAZ levels in vivo.

WAY-151693 is an inhibitor of human collagenase-3 (MMP-13).

Compound 7, 1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran, is an eudesmane-type sesquiterpenoid located in the root bark of Pseudolarix kaempferi [1].

BAY-155 is a powerful and selective menin-MLL inhibitor, exhibiting an IC 50 of 8 nM. It significantly down-regulates MEIS1 gene expression while up-regulating CD11b and MNDA genes. BAY-155 also demonstrates anti-proliferative effects in AML ALL (acute myeloid lymphoblastic leukemia) models [1].

15-Deoxy-15-oxolankamycin exhibits mild activity against Gram-positive bacteria.

15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one is a natural product for research related to life sciences. The catalog number is TN2633 and the CAS number is 1374328-47-8.

5,8,9,10,14-Pentaacetoxy-3-benzoyloxy-15-hydroxypepluane is a natural product for research related to life sciences. The catalog number is TN3097 and the CAS number is 210108-91-1.

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.

ent-6,11-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3951 and the CAS number is 81263-97-0.

ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3953 and the CAS number is 81264-00-8.

ent-7alpha,9-Dihydroxy-15-oxokaur-16-en-19,6bet-olide is a natural product for research related to life sciences. The catalog number is TN3954 and the CAS number is 59885-89-1.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3955 and the CAS number is 81263-96-9.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3956 and the CAS number is 77658-39-0.

ent-9-Hydroxy-15-oxokauran-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5577 and the CAS number is 77658-45-8.

ent-11α,16α-Epoxy-15α-hydroxykauran-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5584 and the CAS number is 77658-46-9.

8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione is a natural product for research related to life sciences. The catalog number is TN5610 and the CAS number is 76497-89-7.

(S)-3-Hydroxy-15-methylhexadecanoyl-CoA ((S)-3-Hydroxy-15-methylhexadecanoyl-coenzyme) is a derivative of coenzyme A.

L-Sophoridine (Matridin-15-one) , a natural product obtained from medicinal plants, which has a variety of pharmacological effects, including anti-Y effects, and selectively induces apoptotic cell death in a variety of human Y cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated.

BIIE-0246 is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 of 15 nM.

Y-320 is a new phenylpyrazoleanilide immunomodulator.

(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg kg prior to occlusion or reperfusion.[5] Reference:[1]. Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem. Biophys. Res. Commun. 104(3), 916-922 (1982).[2]. Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J. Biol. Chem. 257(7), 3771-3781 (1982).[3]. Jiang, J.-X., Zhang, S.-J., Xiong, Y.-K., et al. EETs attenuate ox-LDL-induced LTB4 production and activity by inhibiting p38 MAPK phosphorylation and 5-LO BLT1 receptor expression in rat pulmonary arterial endothelial cells. PLoS One 10(6), e0128278 (2015).[4]. Oltman, C.L., Weintraub, N.L., VanRollins, M., et al. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ. Res. 83(9), 932-939 (1998).[5]. Nithipatikom, K., Moore, J.M., Isbell, M.A., et al. Epoxyeicosatrienoic acids in cardioprotection: Ischemic versus reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 291(2), H537-H542 (2006).

6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg/ml).2 |1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity of 6-substituted indoles. J. Antibiot. (Tokyo) 55(11), 1009-1012 (2002).|2. Nkunya, M.H., Makangara, J.J., and Jonker, S.A. Prenylindoles from Tanzanian Monodora and Isolona species. Nat. Prod. Res. 18(3), 253-258 (2004).