vgsc

VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, and demonstrates a 0.3% inhibition of cell invasion at the same concentration in the MDA-MB-231 human breast cancer cell line, without compromising cell viability.

VGSCs-IN-1 is a potent VGSC inhibitor, a 2-piperazine analog of Riluzole that exhibits good blocking activity on Nav1.4.VGSCs-IN-1 can be used to study cellular excitability disorders.

Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.

Neoline is an active ingredient of A. venetum root (PA) that ameliorates oxaliplatin-induced peripheral neuropathy in mice.Neoline inhibits Nav1.7 voltage-gated sodium channel currents (VGSC). It can be used as a labeling compound to determine the quality of PA products used in the study of neuropathic pain.

μ-Conotoxin KIIIA, an analgesic compound derived from Conus kinoshitai, selectively inhibits mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2), offering potential utility in pain research [1] [2].

Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodium channels (VGSC), notably slowing the rapid inactivation of TTX-resistant (TTX-R) VGSC in cardiac myocytes, with an IC50 of 0.26 μM [1].

μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB), derived from cone snail venom, is a selective blocker of mammalian neuronal voltage-gated sodium channels (VGSC) and is used as a research probe for ion channel function and the investigation of neurological disorders like pain [1].

μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA), derived from cone snail venom, functions as a voltage-gated sodium channel (VGSC) blocker and is utilized in researching neurological diseases [1].

Transfluthrin is a volatile pyrethroid insecticide that targets insect voltage-gated sodium channels (VGSC).

(-)-Sparteine ((-)-Lupinidine) is a quinolizidine alkaloid extracted from lupine, which is a voltage-gated sodium channel (VGSC) blocker with anticonvulsant activity.