Search Result

Search Results for " stress-induced "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T5491	GSK3179106		c-RET
	GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM		c-RET
TP1889	MCL0020	MCL 0020	Melanocortin Receptor
	MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e...		Melanocortin Receptor
T1997	JNJ-31020028	JNJ 31020028	Neuropeptide Y Receptor
	JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors.		Neuropeptide Y Receptor
T16481	PF-04995274		5-HT Receptor
	PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a...		5-HT Receptor
T13867	RH01386		Others
	RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ...		Others
T5913	Sulbutiamine	Bisibuthiamine	Antioxidant
	Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.		Antioxidant
T20797	NE-100 hydrochloride	NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl	Sigma receptor
	NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.		Sigma receptor
T4125	HSF1A		HSP
	HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.		HSP
T5500	DORA-22		OX Receptor
	DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory		OX Receptor
T21824	Sephin1	NSC 65390,IFB-088	Phosphatase
	Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α		Phosphatase
T14491	B022		NF-κB
	B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidati...		NF-κB
T22577	Antalarmin hydrochloride		CRFR , Immunology/Inflammation related
	Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel...		CRFR , Immunology/Inflammation related
T8869	B355252		Others
	B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.		Others
T4400	DIM-C-pPhOH	CDIM8	Apoptosis , Others
	DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi...		Apoptosis , Others
T9564	IRE1α kinase-IN-1		IRE1
	IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph...		IRE1
T34081	Piromelatine	NEU-P-11,NEU-P 11,NEU-P11	P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel
	Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ...
T16550	PKR-IN-C16		Others
	PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the A...		Others
T26684	Auten-99 HBr	Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99	Phosphatase
	Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate th...		Phosphatase
T50032	5-(2-furyl)-N-propylisoxazole-3-carboxamide		Others
	5-(2-furyl)-N-propylisoxazole-3-carboxamide is a compound used as a molecular structural unit and is thought to be a modulator of NMDA receptors, and has been shown to be protective against glutamate-induced excitotoxici...		Others
T7042	1,5-Isoquinolinediol		PARP
	1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol...		PARP
T35449	α-(difluoromethyl)-DL-Arginine	DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine	Others
	α-(difluoromethyl)-DL-Arginine (RMI 71897) is an enzyma-activated, irreversible inhibitor of arginine decarboxylase for E. coli (Ki = 800 μM), Pseudomonas aeruginosa, and Klebsiella pneumoniae. At 0.01 mM, it has been sh...		Others
T26002	Pyclen
	Pyclen is an inhibitor of cell death induced by oxidative stress and an inhibitor of AB1-40 aggregation induced by Cu2+ ion. It can both prevent and disrupt Cu(2+) induced AB(1-40) aggregation.
T25807	MHY884	MHY 884,MHY-884
	MHY884 is an inhibitor of tyrosinase that acts by inhibiting UVB-induced activation of the NF-κB signaling pathway through the downregulation of oxidative stress.
T31263	Deanol aceglumate	Otrun,Deanolo aceglumato,Risatarun,Deanoli aceglumas
	Deanol aceglumate is combination of deanol and N-acetyl-L-glutamic acid. deanol aceglumate can effect Hepatoprotective on stress-induced gastropathy and diabetes mellitus.
T13488	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide	2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide	Prostaglandin Receptor
	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase A2 and prostaglandin E2 in rats subjected to water immersio...		Prostaglandin Receptor
T26596	Allylpyrocatechol
	Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways.
T10809	CHPG		Others
	CHPG is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB pathway.		Others
T68959	Fenobam hydrate
	Fenobam hydrate is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate and inhibits ba...
T71479	Kahweol oleate
	Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell ...
T26172	S3QEL-2	S3QEL2,S3QEL 2
	S3QEL-2 is a retrograde signaling modulator. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ß-cells from intact islets.
T68398	MI-223
	MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
T3689L	Ruboxistaurin mesylate	LY-333531,LY333531,LY 333531,LY-333531 Mesylate
	Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic ne...
T27107	CYM-5478	CYM 5478,CYM5478
	CYM-5478 is a potent and selective S1P2 agonist. Under nutrient-deprivation stress produced by serum-starvation, CYM-5478 induced a significant increase in the viability of C6 cells in a dose dependent manner at concentr...
T34811	Terrein	NSC 291308,Terrain,(+)Terrein,NSC291308,NSC-291308
	Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+...
T68642	Kahweol palmitate
	Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducin...
T71478	Kahweol stearate
	Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing...
T25576	KF 392	KF392,KF-392
	KF 392 is antiulcer. It was found that KF-392 given orally to rats at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions.
T69068	Aspulvinone H
	Aspulvinone H is a natural inhibitor of glutamic oxaloacetate transaminase 1 (GOT1), suppressing glutamine metabolism, making PDAC cells sensitive to oxidative stress and inhibiting cell proliferation, exhibiting potent ...
T71480	Kahweol linoleate
	Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing...
T68641	Kahweol Acetate
	Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing ...
T38228	R 121919 hydrochloride
	High affinity corticotropin releasing factor receptor1 (CRF1) antagonist (Ki = 3.5 nM). Reduces stress-induced elevations of plasma ACTH. Anxiolytic and antidepressant in vivo. Orally bioavailable. Chen and Grigoriadis (...
T83050	Anti-inflammatory agent 62
	Anti-inflammatory agent 62 mitigates acetaminophen-induced hepatotoxicity in HepG2 cells by modulating inflammatory and oxidative stress pathways [1].
T73096	Z-LEVD-FMK
	Z-LEVD-FMK, a cell-permeable caspase-4 inhibitor, effectively blocks endoplasmic reticulum (ER) stress-induced apoptosis in cancer cells.
T81970	Kuwanon T
	Kuwanon T, an isoprenylated flavonoid extracted from the root bark of Morus alba, exhibits protective effects against t-BHP-induced oxidative stress, presenting an EC50 value of 30.32 μM [1].
T24883	Tingenin B	22-Hydroxytingenone
	Tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Tingenin b was cytotoxic against MCF-7s (IC50: 2.38 μM for 48 h) by inducing apoptosis. Endoplasmic re...
T36328	Termitomycamide B
	Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion disease...
T72543	BOLD-100 free base	NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base
	BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded pr...
T35670	Miro1 Reducer
	Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochon...
T76195	Stresscopin-related peptide (human)
	Stresscopin-related peptide (human), a specific ligand for the type 2 CRH receptor, effectively suppresses food intake, delays gastric emptying, and decreases heat-induced edema. It plays a crucial role in maintaining ho...
T63364	Nrf2 activator-5
	Nrf2 activator-5 is a potent activator of Nrf2 that attenuates H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglia, exhibiting antioxidant and anti-inflammatory activity.

Compounds

Target: Melanocortin Receptor

JNJ-31020028

T1997

Synonym: JNJ 31020028

Target: Neuropeptide Y Receptor

PF-04995274

T16481

Synonym:

Target: 5-HT Receptor

Synonym: Bisibuthiamine

Target: Antioxidant

NE-100 hydrochloride

T20797

Synonym: NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl

Target: Sigma receptor

Synonym: NSC 65390,IFB-088

Antalarmin hydrochloride

T22577

Synonym:

Target: CRFR, Immunology/Inflammation related

Target: Apoptosis, Others

Synonym: NEU-P-11,NEU-P 11,NEU-P11

Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel

Synonym: Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99

Target: Phosphatase

5-(2-furyl)-N-propylisoxazole-3-carboxamide

α-(difluoromethyl)-DL-Arginine

T35449

Synonym: DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine

Synonym: MHY 884,MHY-884

Target:

Deanol aceglumate

T31263

Synonym: Otrun,Deanolo aceglumato,Risatarun,Deanoli aceglumas

Target:

2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide

T13488

Synonym: 2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide

Target: Prostaglandin Receptor

Synonym: S3QEL2,S3QEL 2

Ruboxistaurin mesylate

T3689L

Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate

Target:

CYM-5478

T27107

Synonym: CYM 5478,CYM5478

Target:

Terrein

T34811

Synonym: NSC 291308,Terrain,(+)Terrein,NSC291308,NSC-291308

Synonym: KF392,KF-392

R 121919 hydrochloride

T38228

Synonym:

Target:

Anti-inflammatory agent 62

Synonym: 22-Hydroxytingenone

Synonym: NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base

Stresscopin-related peptide (human)

Cat No.	Product Name	Synonyms	Targets
T3S0488	Syringaresinol diglucoside	Syringaresinol-di-O-glucoside	Others
	Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) protects the animals from the stress-induced decreases in sex behaviours and in rectal temperature, the stress-induced failure of retrieval of memory, and the st...		Others
T0632	3,4,5-Trimethoxybenzoic acid	Gallic acid trimethyl ether,Eudesmic acid,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid	Antioxidant
	3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice. It...		Antioxidant
T8704	4-hydroxyphenyl acetate		Nrf2
	4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer		Nrf2
T6S1768	Narcissin	Isorhamnetin 3-Rutinoside,Narcissoside	Antioxidant
	Narcissin (Isorhamnetin 3-Rutinoside), with synergism of B.flavum flavonoid and rutin, could be responsible for stronger protection against mitochondrial induced oxidative stress.		Antioxidant
T2805	Chlorogenic Acid	NSC-407296,3-O-Caffeoylquinic acid,Heriguard	Others , Influenza Virus , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Antibacterial
	Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats.
TN1058	Pelargonidin chloride		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
T5665	Geraniol		Others , Endogenous Metabolite , Antifungal
	geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress.		Others , Endogenous Metabolite , Antifungal
TN1600	Eclalbasaponin I		Others
	Eclalbasaponin I has anti-oxidative, and antitumor activities, it reduces oxidative stress-induced neural cell death by autophagy activation, it can dose-dependently inhibit the proliferation of hepatoma cell smmc-7721 w...		Others
TN1594	DL-Syringaresinol	(±)-Syringaresinol	Antioxidant , Antifungal
	DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin agi...		Antioxidant , Antifungal
T4868	Gamma-Linolenic acid	gamolenic acid,γ-Linolenic acid	Endogenous Metabolite
	gamma-Linolenic acid (gamolenic acid), is an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. Research on hepatocellular cell lines has shown γ-Linolenic Acid to have induced r...		Endogenous Metabolite
T3860	Isoliquiritin apioside		MMP , p38 MAPK , NF-κB
	Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...		MMP , p38 MAPK , NF-κB
T2S0690	Ecliptasaponin A	Echinocystic acid-3-o-glucoside	Others
	1. Ecliptasaponin A (Echinocystic acid-3-o-glucoside) has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-...		Others
TN1461	(-)-Butin	Butin	Akt , PI3K , Nrf2
	(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SO...		Akt , PI3K , Nrf2
T11685	Isolongifolene	(-)-Isolongifolene	Apoptosis , Others
	Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative ...		Apoptosis , Others
T6S0221	Eriocitrin	eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside	Apoptosis , Carbonic Anhydrase
	1. Eriocitrin (Eriodictyol-7-O-Rutinoside) is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in a rat model of high-fat diet....		Apoptosis , Carbonic Anhydrase
TN1957	Mulberrofuran Q	MulberrofuranQ
	Mulberrofuran Q is an active compound that inhibits the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase product) , which protects neuronal cells from hypoxia-glycorrhoea-def...
T6S1966	Curculigoside	Curculigoside A	Antioxidant , NF-κB , JAK , STAT
	1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disord...		Antioxidant , NF-κB , JAK , STAT
T3395	Timosaponin AIII	Filiferin B,AneMarsaponin A3,Timosaponin A3	AChE , mTOR
	Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC...		AChE , mTOR
TN1601	Effusol		Caspase
	Effusol is a natural product, exhibits potent scavenging activity for DPPH and ABTS radicals(IC50 values of 79 μM and 2.73 μM, respectively). Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampa...		Caspase
T3753	Sinapinic Acid	Sinapic acid,Synapoic acid	Apoptosis , RAAS , Reactive Oxygen Species , HDAC
	Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...		Apoptosis , RAAS , Reactive Oxygen Species , HDAC
T2909	Fraxetin	7,8-dihydroxy-6-methoxy coumarin	Apoptosis , Others
	Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m...		Apoptosis , Others
T3795	Corilagin		Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy
	Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B...
TN1413	Atranorin		Endogenous Metabolite , NO Synthase , Ras
	Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotectiv...		Endogenous Metabolite , NO Synthase , Ras
TWS1977	Kamebakaurin	Kamebakaurine	NF-κB
	1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression...		NF-κB
T4001	Euxanthone	1,7-Dihydroxyxanthone	Autophagy
	Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stres...		Autophagy
T40615	N,N'-Dimethylthiourea	DMTU	Antioxidant
	N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects a...		Antioxidant
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T2854	Phillyrin	Forsythin	P450 , Influenza Virus , AMPK
	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ...		P450 , Influenza Virus , AMPK
T6S1784	Brazilin	Natural Red 24,Braziletto,Brasilin,Superbresiline	Apoptosis , Others , AMPK , Autophagy
	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign...		Apoptosis , Others , AMPK , Autophagy
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
T3414	Morroniside		Apoptosis , MMP , Pyroptosis
	Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib...		Apoptosis , MMP , Pyroptosis
T3779	Crocin II	Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B	Caspase , COX , NO Synthase
	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...		Caspase , COX , NO Synthase
T6S0735	Flavokawain B	Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis , Others
	1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in...		Apoptosis , Others
T4719	1,4-D-Gulonolactone	D-Gulonic acid γ-lactone	Others , Endogenous Metabolite
	1,4-D-Gulonolactone (D-Gulonic acid γ-lactone) (also known as reduced ascorbic acid, RAA) is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase (EC 1.1.3.8), which catalyzes the last step of the biosynthesis...		Others , Endogenous Metabolite
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
TN1163	2'-Hydroxychalcone		Others
	2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxyc...		Others
T37512	Cis-4-Hydroxy-L-proline		Endogenous Metabolite
	cis-L-Hydroxyproline inhibits the synthesis and extracellular deposition of collagen. The growth inhibition of pancreatic cancer cells induced by the Hyp isomer could be due to endoplasmatic reticulum stress.		Endogenous Metabolite
T24025	Eckol
	Eckol inhibits ultraviolet B-induced cell damage by a decrease in oxidative stress in human keratinocytes.
TN1581	Dihydroguaiaretic acid		COX , DNA/RNA Synthesis
	Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.		COX , DNA/RNA Synthesis
TN4941	Sanggenon N		Others
	Sanggenon N shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 23.45 ± 4.72 uM. It inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.		Others
T19576	Tetrahydrocortisone		Others
	Tetrahydrocortisone, a stress-induced hormone and a urinary metabolite of Cortisone, originates from the reduction of Cortisone facilitated by 5-reductase.		Others
TN3473	Axillarin
	Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress.
TN1542	Cycloheterophyllin		NADPH-oxidase , PKA , PKC
	Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.		NADPH-oxidase , PKA , PKC
TN6613	Delphinidin-3-O-galactoside chloride
	Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cyto...
T27711	Kahweol Eicosanate	J002075,J 002075,J-002075
	Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, ...
TN3618	Cedrin		Beta Amyloid , BCL , Caspase
	Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppres...		Beta Amyloid , BCL , Caspase
TN4465	Luvangetin		COX , Prostaglandin Receptor , Antifection
	Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rat...		COX , Prostaglandin Receptor , Antifection
TN4587	Mulberrofuran C		HSV
	Mulberrofuran C shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 0.41 ± 0.48 uM ; it also shows protective effects on glutamate-induced cell death with the EC50 value of 16.50 ± 7.82 uM. ...		HSV
TN2287	Turkesterone		Calcium Channel
	Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodulating and antistress activity, can increase the adaptation ...		Calcium Channel
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Natural Products

Syringaresinol diglucoside

T3S0488

Synonym: Syringaresinol-di-O-glucoside

Target: Others

3,4,5-Trimethoxybenzoic acid

T0632

Synonym: Gallic acid trimethyl ether,Eudesmic acid,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid

Target: Antioxidant

4-hydroxyphenyl acetate

Synonym: Isorhamnetin 3-Rutinoside,Narcissoside

Target: Antioxidant

Chlorogenic Acid

T2805

Synonym: NSC-407296,3-O-Caffeoylquinic acid,Heriguard

Target: Others, Influenza Virus, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Antibacterial

Pelargonidin chloride

TN1058

Synonym:

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Geraniol

T5665

Synonym:

Target: Others, Endogenous Metabolite, Antifungal

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

gamma-Linolenic acid

T4868

Synonym: gamolenic acid,γ-Linolenic acid

Target: Endogenous Metabolite

Isoliquiritin apioside

T3860

Synonym:

Target: MMP, p38 MAPK, NF-κB

Ecliptasaponin A

T2S0690

Synonym: Echinocystic acid-3-o-glucoside

Target: Akt, PI3K, Nrf2

Isolongifolene

T11685

Synonym: (-)-Isolongifolene

Target: Apoptosis, Others

Eriocitrin

T6S0221

Synonym: eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside

Target: Apoptosis, Carbonic Anhydrase

Mulberrofuran Q

TN1957

Synonym: MulberrofuranQ

Target:

Curculigoside

T6S1966

Synonym: Curculigoside A

Target: Antioxidant, NF-κB, JAK, STAT

Timosaponin AIII

T3395

Synonym: Filiferin B,AneMarsaponin A3,Timosaponin A3

Synonym: Sinapic acid,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Fraxetin

T2909

Synonym: 7,8-dihydroxy-6-methoxy coumarin

Target: Apoptosis, Others

Corilagin

T3795

Synonym:

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Atranorin

TN1413

Synonym:

Target: Endogenous Metabolite, NO Synthase, Ras

Kamebakaurin

TWS1977

Synonym: Kamebakaurine

Target: NF-κB

Euxanthone

T4001

Synonym: 1,7-Dihydroxyxanthone

Target: Autophagy

N,N'-Dimethylthiourea

Target: ERK, p38 MAPK, NF-κB

Phillyrin

T2854

Synonym: Forsythin

Target: P450, Influenza Virus, AMPK

Brazilin

T6S1784

Synonym: Natural Red 24,Braziletto,Brasilin,Superbresiline

Target: Apoptosis, Others, AMPK, Autophagy

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

5,7-Dihydroxychromone

T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Morroniside

T3414

Synonym:

Target: Apoptosis, MMP, Pyroptosis

Crocin II

T3779

Synonym: Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B

Target: Caspase, COX, NO Synthase

Flavokawain B

T6S0735

Synonym: Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

1,4-D-Gulonolactone

T4719

Synonym: D-Gulonic acid γ-lactone

Target: Others, Endogenous Metabolite

Obtusifolin

T4S0969

Synonym:

Target: Antioxidant, NF-κB

cis-4-Hydroxy-L-proline

T37512

Synonym:

Target: Endogenous Metabolite

Dihydroguaiaretic acid

TN1581

Synonym:

Target: COX, DNA/RNA Synthesis

Target: NADPH-oxidase, PKA, PKC

Delphinidin-3-O-galactoside chloride

Synonym: J002075,J 002075,J-002075

Target: Beta Amyloid, BCL, Caspase

Luvangetin

TN4465

Synonym:

Target: COX, Prostaglandin Receptor, Antifection

Target: Calcium Channel

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00433	VSIR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	Human Cells
	platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling...
TMPJ-01372	Cornulin Protein, Human, Recombinant (His)	Human	E. coli
	Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-ter...
TMPJ-01382	HSPB8 Protein, Human, Recombinant (His)	Human	E. coli
	Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in t...
TMPY-01066	MICB Protein, Human, Recombinant (His)	Human	HEK293
	MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related prote...
TMPY-00991	LIFR Protein, Human, Recombinant (His)	Human	HEK293
	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff...
TMPY-05493	LIFR Protein, Human, Recombinant (hFc)	Human	HEK293
	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff...
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-03523	ANGPTL4 Protein, Human, Recombinant (His)	Human	HEK293
	ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancrea...
TMPY-02053	MICA Protein, Human, Recombinant (His), MICA*018	Human	HEK293
	MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree ...
TMPY-05476	MICA Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree ...
TMPY-01694	Clusterin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-01691	Clusterin Protein, Human, Recombinant (CLU34, His)	Human	HEK293
	Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPH-02681	GPX7 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
TMPH-02298	Urocortin-3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
TMPH-02587	CIRBP Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpres...
TMPH-02135	SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiati...
TMPH-01502	Humanin Protein, Human, Recombinant (GST)	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-00730	RpoS Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and...
TMPH-01313	EIF4G1 Protein, Human, Recombinant (His)	Human	Yeast
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F c...
TMPH-03443	GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)	Saccharomyces cerevisiae	E. coli
	Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the pres...
TMPY-02390	SSPA Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Stringent starvation protein A (ssPA), a member of the GST superfamily, is an RNA polymerase-associated transcriptional activator for the lytic development of phage P1 and is essential for stationary phase-induced acid t...
TMPH-02506	ANG Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S...
TMPH-00731	RpoS Protein, E. coli, Recombinant	E. coli	E. coli
	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and...
TMPH-01312	EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)	Human	E. coli
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F c...
TMPH-01851	PSIP1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens ...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-00085	SIZ1 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli
	E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses. Functions as an upstream negative regulator of s...
TMPH-03274	ATF-4 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, an...
TMPK-00246	MICB Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antige...
TMPK-00247	MICB Protein, Human, Recombinant (hFc)	Human	HEK293
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antige...
TMPK-00245	MICB Protein, Human, Recombinant (His & Avi)	Human	HEK293
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antige...
TMPJ-00754	CRYAA Protein, Human, Recombinant (His)	Human	E. coli
	Alpha-Crystallin A Chain (CRYAA) belongs to the small heat shock protein (HSP20) family and can be induced by heat shock. The expression of CRYAA is preferentially restricted to the lens cell. CRYAA may contribute to the...
TMPY-02072	HSF1 Protein, Human, Recombinant (His)	Human	E. coli
	Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock...
TMPY-04425	PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated...
TMPY-02732	ARMET/MANF Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of...
TMPY-01678	ARMET/MANF Protein, Human, Recombinant (His)	Human	HEK293
	Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of...
TMPY-00885	MICB Protein, Human, Recombinant (His & hFc)	Human	HEK293
	MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related prote...
TMPH-02929	TXNIP Protein, Mouse, Recombinant (His)	Mouse	Yeast
	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated ...
TMPH-02200	TXNIP Protein, Human, Recombinant (B2M & His)	Human	in vitro E. coli expression system
	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated ...
TMPY-00028	ARMET/MANF Protein, Human, Recombinant (hFc)	Human	HEK293
	Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of...
TMPY-02299	ALDH3A1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (...
TMPY-01597	LIFR Protein, Mouse, Recombinant (His)	Mouse	HEK293
	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff...
TMPY-04378	MAPKAPK3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ...
TMPY-02150	GADD45A Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulatio...
TMPJ-00246	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to T...
TMPY-04122	ATOX1 Protein, Human, Recombinant (His)	Human	E. coli
	ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the t...
TMPY-06010	LIFR Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff...
TMPY-06892	LIFR Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff...
TMPY-03306	LIFR Protein, Rat, Recombinant (His)	Rat	HEK293
	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff...
TMPH-02322	SLC30A10 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic p...
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VSIR Protein, Cynomolgus, Recombinant (His)

TMPJ-00433

Species: Cynomolgus

Expression System: Human Cells

Cornulin Protein, Human, Recombinant (His)

TMPJ-01372

Species: Human

Expression System: E. coli

HSPB8 Protein, Human, Recombinant (His)

TMPJ-01382

Species: Human

Expression System: E. coli

MICB Protein, Human, Recombinant (His)

TMPY-01066

Species: Human

Expression System: HEK293

LIFR Protein, Human, Recombinant (His)

TMPY-00991

Species: Human

Expression System: HEK293

LIFR Protein, Human, Recombinant (hFc)

TMPY-05493

Species: Human

Expression System: HEK293

C-ABL/ABL1 Protein, Human, Recombinant (GST)

TMPY-04396

Species: Human

Expression System: Baculovirus-Insect Cells

ANGPTL4 Protein, Human, Recombinant (His)

TMPY-03523

Species: Human

Expression System: HEK293

MICA Protein, Human, Recombinant (His), MICA*018

TMPY-02053

Species: Human

Expression System: HEK293

MICA Protein, Cynomolgus, Recombinant (His)

TMPY-05476

Species: Cynomolgus

Expression System: HEK293

Clusterin Protein, Mouse, Recombinant (His)

TMPY-01694

Species: Mouse

Expression System: HEK293

Clusterin Protein, Human, Recombinant (CLU34, His)

TMPY-01691

Species: Human

Expression System: HEK293

GPX7 Protein, Mouse, Recombinant (His & Myc)

TMPH-02681

Species: Mouse

Expression System: E. coli

Urocortin-3 Protein, Human, Recombinant (His & SUMO)

TMPH-02298

Species: Human

Expression System: E. coli

CIRBP Protein, Mouse, Recombinant (His)

TMPH-02587

Species: Mouse

Expression System: E. coli

SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)

TMPH-02135

Species: Human

Expression System: E. coli

Humanin Protein, Human, Recombinant (GST)

TMPH-01502

Species: Human

Expression System: E. coli

RpoS Protein, E. coli, Recombinant (His)

TMPH-00730

Species: E. coli

Expression System: E. coli

EIF4G1 Protein, Human, Recombinant (His)

TMPH-01313

Species: Human

Expression System: Yeast

GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)

TMPH-03443

Species: Saccharomyces cerevisiae

Expression System: E. coli

SSPA Protein, E. coli, Recombinant (His)

TMPY-02390

Species: E. coli

Expression System: E. coli

ANG Protein, Mouse, Recombinant (His)

TMPH-02506

Species: Mouse

Expression System: E. coli

RpoS Protein, E. coli, Recombinant

TMPH-00731

Species: E. coli

Expression System: E. coli

EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)

TMPH-01312

Species: Human

Expression System: E. coli

PSIP1 Protein, Human, Recombinant (His & SUMO)

TMPH-01851

Species: Human

Expression System: E. coli

Humanin Protein, Human, Recombinant (hFc)

TMPH-01503

Species: Human

Expression System: HEK293

SIZ1 Protein, Arabidopsis thaliana, Recombinant (His)

TMPH-00085

Species: Arabidopsis thaliana

Expression System: E. coli

ATF-4 Protein, Rat, Recombinant (His & Myc)

TMPH-03274

Species: Rat

Expression System: E. coli

MICB Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00246

Species: Human

Expression System: HEK293

MICB Protein, Human, Recombinant (hFc)

TMPK-00247

Species: Human

Expression System: HEK293

MICB Protein, Human, Recombinant (His & Avi)

TMPK-00245

Species: Human

Expression System: HEK293

CRYAA Protein, Human, Recombinant (His)

TMPJ-00754

Species: Human

Expression System: E. coli

HSF1 Protein, Human, Recombinant (His)

TMPY-02072

Species: Human

Expression System: E. coli

PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)

TMPY-04425

Species: Human

Expression System: Baculovirus-Insect Cells

ARMET/MANF Protein, Mouse, Recombinant (His)

TMPY-02732

Species: Mouse

Expression System: HEK293

ARMET/MANF Protein, Human, Recombinant (His)

TMPY-01678

Species: Human

Expression System: HEK293

MICB Protein, Human, Recombinant (His & hFc)

TMPY-00885

Species: Human

Expression System: HEK293

TXNIP Protein, Mouse, Recombinant (His)

TMPH-02929

Species: Mouse

Expression System: Yeast

TXNIP Protein, Human, Recombinant (B2M & His)

TMPH-02200

Species: Human

Expression System: in vitro E. coli expression system

ARMET/MANF Protein, Human, Recombinant (hFc)

TMPY-00028

Species: Human

Expression System: HEK293

ALDH3A1 Protein, Human, Recombinant (His)

TMPY-02299

Species: Human

Expression System: Baculovirus-Insect Cells

LIFR Protein, Mouse, Recombinant (His)

TMPY-01597

Species: Mouse

Expression System: HEK293

MAPKAPK3 Protein, Human, Recombinant (GST)

TMPY-04378

Species: Human

Expression System: Baculovirus-Insect Cells

GADD45A Protein, Human, Recombinant (His & GST)

TMPY-02150

Species: Human

Expression System: Baculovirus-Insect Cells

TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc)

TMPJ-00246

Species: Mouse

Expression System: Human Cells

ATOX1 Protein, Human, Recombinant (His)

TMPY-04122

Species: Human

Expression System: E. coli

LIFR Protein, Human, Recombinant (His), Biotinylated

TMPY-06010

Species: Human

Expression System: HEK293

LIFR Protein, Rhesus, Recombinant (His)

TMPY-06892

Species: Rhesus

Expression System: HEK293

LIFR Protein, Rat, Recombinant (His)

TMPY-03306

Species: Rat

Expression System: HEK293

SLC30A10 Protein, Human, Recombinant (His & Myc)

TMPH-02322

Species: Human

Expression System: E. coli

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Cat No.	Product Name
L9700	Endoplasmic Reticulum Stress Compound Library		193 compounds
	A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);

Libraries

Endoplasmic Reticulum Stress Compound Library

L9700

Compounds: 193