snap

SNAP is a nitric oxide donor that acts as a stable inhibitor of platelet aggregation. SNAP has played a pivotal role in elucidating nitric oxide–mediated mechanisms in liver fibrosis, hepatic stellate cell phenotype maintenance, and S-nitrosylation pathways in breast cancer models to counteract radiation-induced oxidative stress. SNAP additionally functions as a P-glycoprotein/BCRP inhibitor to enhance radiotracer quantification in rats, while its application as a protease inhibitor in cardiac tissue homogenization has advanced the study of cardiac fibrosis progression and associated biochemical processes.

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.

SNAP 398299 is a Glycopeptide Receptor Type 3 (Gal3) antagonist with anxiolytic and antidepressant-like effects and is used in the study of mood disorders.

SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)

SNAP-fusion protein ligand-1 (Compound 1i) serves as a ligand for a target protein in PROTAC (Ligand for Target Protein for PROTAC) applications. It is used in the synthesis of PROTAC VHL-SNAP2-5C.

α1A-adrenoceptor antagonist

SNAP-7941 is a selective antagonist of the melanin concentrating hormone receptor MCH1 with promising anxiolytic, antidepressant and anorectic effects in initial animal studies.

SNAP-8719 is a selective antagonist of α1D-AR. SNAP-8719 showed better selectivity for α1D-AR and lower binding affinity for the 5-HT1A receptor.

SNAP 94847 (SNAP-94847) is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice.

SNAP-5089 is a highly selective alpha1A-adrenoceptor antagonist.

Alkyne-PEG5-SNAP is a chemical reagent characterized by its alkyne group. This compound can conjugate with benzyl guanine (BG), where the BG moiety undergoes a specific and rapid reaction with the SNAP-tag (a type of peptide protein tag), facilitating irreversible and covalent labeling of SNAP fusion proteins, and provides additional alkyne functionality for further coupling. Additionally, Alkyne-PEG5-SNAP serves as a click chemistry reagent that interacts with molecules containing azide groups through a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC).

Alkyne-SNAP (compound 3) is an alkyne-coupled benzylguanine that interacts with SNAP-tag for irreversible covalent labeling of SNAP fusion proteins. The alkyne segment of the molecule can subsequently undergo click chemistry for further labeling.

This amino acids187 to 203 fragment is derived from the C-terminal helix of synaptosomal-associated protein of 25 kDa (SNAP-25). This peptide is able to rescue exocytosis from botulinum neurotoxin E (BoNT/E)-treated cells, albeit at higher concentrations

Diminishing the appearance of wrinkles.

(S)-SNAP5114 is a selective inhibitor of GABA transport, exhibiting IC50 values of 5 μM for hGAT-3 and 21 μM for rGAT-2, and possesses anticonvulsant properties.

VHL-SNAP2-5C is a PROTAC degrader based on the self-labeling protein SNAP tag. It enables visualization and selective removal of SNAP-fusion proteins, such as CLCa and EGFP, when endogenously labeled.

SNAP8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2) is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation.

L-771688 (SNAP 6383) is a novel potent and selective α1A-adrenoceptor antagonist with a Ki value of 0.43±0.02 nM.L-771688 KE is used for the treatment of benign prostatic hyperplasia.

N-Acetyl-DL-penicillamine is a chelating agent.1,2,3It inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells when used at a concentration of 1 mM.1,2N-Acetyl-DL-penicillamine (3 mmol/kg per day, p.o.) reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice when administered following injection of methyl mercuric chloride. It decreases mercuric chloride-induced mortality in mice when administered orally at a dose of 1.6 mmol/kg.3N-Acetyl-DL-penicillamine is also an analog of SNAP that does not generate nitric oxide and has been used as a negative control in experiments using SNAP.4,5

BGN3 is a suitable substrate for both SNAP-tag and H 5 enzymes, exhibiting reasonable activities with IC50 values of 15.6 μM and 23.5 μM, respectively.

HaXS8 is a dimerizer that facilitates the covalent and irreversible intracellular dimerization of proteins of interest labeled with HaloTag and SNAP-tag. Furthermore, HaXS8 does not exhibit any interference with PI3K/mTOR signaling.

Isosaponarin is a natural product with multiple activities. It inhibits the increase in Ca2+ levels induced by 4-aminopyridine in rat synaptosomes without affecting the membrane potential of synaptosomes, while reducing the phosphorylation of PKC, PKCα, SNAP-25, and MARCKS, thereby inhibiting the release of glutamate from vesicles in synaptosomes.

HT-2157 (SNAP-37889) is a selective, high-affinity competitive antagonist of the galanin-3 receptor (Gal3), demonstrating effective inhibition of this target.

T4 UvsX Recombinase initiates DNA replication on double-stranded templates by catalyzing synapsis with a homologous primer single strand. It significantly enhances the snap-back (hairpin-primed) DNA synthesis catalyzed by the T4 DNA polymerase holoenzyme on linear, single-stranded templates [1].