sk-ov-3 cells

CCT251236 is a cell-based phenotypic high-throughput screening (HTS) chemical probe developed to screen for inhibitors of the HSF1 stress pathway.CCT251236 exhibits antimyeloma activity and inhibits HSF1.

NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.

RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.

Tubulin inhibitor 8 is an inhibitor of tubulin and various cancer cell lines and inhibits tubulin polymerisation and K562 cell growth with an IC50 of 0.73 μM and 14 nM respectively.

ATG7-IN-1 is a highly potent, selective small-molecule ATG7 inhibitor with an IC₅₀ of 62 nM. ATG7-IN-1 blocks the formation of the ATG12-ATG5 and LC3-PE conjugate system at both the cellular and in vivo levels, thereby inhibiting autophagosome formation. ATG7-IN-1 can be used in research on autophagy mechanisms.

Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death. Carboplatin has antitumor activity.

Capsaicin is an active natural component found in chili peppers and acts as a TRPV1 agonist (EC50 = 0.29 μM). It possesses multiple activities, including pain relief, antitumor, anti-inflammatory, antioxidant, and neuroprotective effects, as well as some neurotoxicity. Capsaicin can be used to establish itch models.

HP-β-CD (Hydroxypropyl betadex) is a water-soluble cyclodextrin derivative obtained by hydroxypropylation of β-cyclodextrin. HP-β-CD serves as a drug delivery carrier that enhances stability and bioavailability.

Duocarmycin TM belongs to natural products, serving as a DNA alkylating agent with sequence-selective double-stranded DNA alkylation capability, featuring high cell permeability and potent antitumor activity, for targeted therapy including drug-resistant and low-proliferative tumors.

SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).

IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.

Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3a binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3a has antitumor activity.

Vorsetuzumab mafodotin (SGN‑75) is an auristatin-based, CD70-targeted antibody-drug conjugate (ADC), composed of the humanized monoclonal antibody Vorsetuzumab and the ADC cytotoxic molecule MMAF, and exerts antitumor effects.

4F-Docetaxel (4FDT) is a fluorinated derivative of docetaxel that exhibits significant antitumor activity against hepatocellular carcinoma (HCC) and is suitable for research on liver cancer.

HDAC10-IN-3 (Compound 2a) is a potent inhibitor of HDAC10, with IC50 values of 0.41, 37, 350, and 4500 nM for HDAC10, HDAC6, HDAC8, and HDAC1, respectively. It exhibits moderate cytotoxicity against KB and SK-OV-3 cells but shows no significant cytotoxicity against most cancer cell lines. HDAC10-IN-3 can be utilized in cancer research.

4-Chloro-7-ethoxyquinoline (Compound 9a) is a quinoline derivative with anticancer properties. It effectively inhibits the proliferation of HCT-116, RKO, DLD1, HepG2, BGC-823, NCI-H1650, and SK-OV-3 cells, with IC50 values of 3.16, 3.87, 2.75, 2.66, 3.91, 3.34, and 3.46 μM, respectively.

IDO1-IN-13 (compound 27a) is a potent IDO1 inhibitor with an IC50 of 61.6 nM. It inhibits cell IDO1 with an EC50 of 30 nM for HeLa cells and reduces the kyn/trp ratio by 51% in SK-OV-3 xenograft tumor tissue.

Antitumor agent-61 (Compound 9b), an Irinotecan (Ir) derivative, demonstrates potent anticancer activity with IC50 values ranging from 0.92 to 3.23 μM against six human cancer cell lines: SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549, and MG-63, and specifically induces apoptosis in SK-OV-3 cells via mitochondrial pathways [1].

Glucozaluzanin C, a lignan extracted from the MeOH extract of Ainsliaea acerifolia (Compositae) roots, demonstrates ED50 values of 2.45 μg/mL for A549 cells, 1.37 μg/mL for SK-OV-3 cells, 0.40 μg/mL for SK-MEL-2 cells, 1.41 μg/mL for XF498 cells, and 1.43 μg/mL for HCT15 cells, respectively [1].

Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the proliferation of cultured human tumor

Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.

Przewaquinone A is a natural product exhibiting inhibitory activity against cancer cells such as A549, HCT15, and SK-OV-3.

Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.

Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.