scutellaria

Norwogonin (5,7,8-Trihydroxyflavone), isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).

6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM.

(2R)-6-Methoxynaringenin is one of the potentially active components in Scutellaria baicalensis.

Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from Scutellaria baicalensis that exhibits anti-inflammatory, antioxidant, antitumor, and antiviral activity. Baicalin can be used in research on inflammation, neurodegenerative diseases, tumors, and metabolic syndrome.

Scutellarin (Breviscapin) is a natural flavonoid isolated from Scutellaria baicalensis that exhibits antioxidant, anti-inflammatory, antithrombotic, neuroprotective, and cardioprotective and neuroprotective activities. Scutellarin demonstrates antiviral activity against HIV-1 IIIB, HIV-1 (74V), and HIV-1 KM018. Scutellarin inhibits the RANKL-mediated MAPK/NF-κB pathway (IC₅₀ = 10 μM) and activates the Nrf2/HO-1 antioxidant pathway (EC₅₀ = 5 μM). Scutellarin can be used in natural product development and basic research on cardiovascular and cerebrovascular diseases.

Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.

1. Malic acid (Pomalus acid) did reduce populations of L. monocytogenes on poultry. 2. Malic acid supplementation may be useful for conservative treatment of calcium renal stone disease by virtue of its capacity to induce these effects.

Terpinyl Butyrate is a terpenoid ester widely used in biochemical experiments and drug synthesis research.

Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.

Scutellarin methyl ester has the effect of improving sleep, such as prolonging sleep time, increasing the incidence of sleep, shortening sleep latency, which also helps to delay aging process.

1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.

Darendoside B is a new phenethyl alcohol glycosides, were isolated from the methanolic extract of the aerial parts of Scutellaria orientalis subsp.

Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.

Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.

Oroxin B has antioxidant activity.

Oroxylin A 7-O-β-d-glucuronide and wogonoside should also be served as the chemical markers together with baicalin for the quality control of herbs and proprietary traditional Chinese medicine (PTCM) products of radix Scutellariae. Oroxylin A 7-O-glucuronide, Oroxin A, and Oroxin B can bind to the "stem" region of α-hemolysin (α-HL), when inhibiting the hemolytic activity of α-HL. Oroxylin A 7-O-glucuronide and 4', 5, 7-trihydroxy-6-methoxyflavone at a concentration of 100 microM inhibit 34 and 43% of total prolyl oligopeptidase (POP) activity, respectively.

Viscidulin I, a natural product found in Scutellaria baicalensis, exhibits distinct chemical properties.

MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.

Oroxin A (Baicalein 7-O-glucoside) has antitussive and expectorant effects.

5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.

Oroxylin A 7-O-β-D-glucuronide methyl ester, a natural product, can be isolated from the roots of *Scutellaria baicalensis* Georgi [1].

Dihydrobaicalin, a flavonoid glycoside, is isolated from the American skullcap (Scutellaria lateriflora L.) [1].

5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.

5,7,8-Trihydroxy-6-methoxyflavone-7-O-glucuronide is a naturally occurring compound extractable from Scutellaria baicalensis Georgi [1].