reticulocyte

YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.

Actinobolin hemisulfate ((+)-Actinobolin hemisulfate) is the hemisulfate salt form of Actinobolin. This antibiotic functions by targeting ribosomes in both bacteria and eukaryotes to inhibit protein synthesis. Actinobolin hemisulfate exhibits inhibitory effects on Mycobacterium smegmatis, Escherichia coli, and rabbit reticulocyte lysate (RRL) with IC50 values of 19.2, 27.9, and 288 μmol L, respectively.

Actinobolin ((+)-Actinobolin) is an antibiotic that inhibits protein synthesis by targeting ribosomes in both bacteria and eukaryotes. It suppresses the activity of Mycobacterium smegmatis, Escherichia coli, and rabbit reticulocyte lysate (RRL), with IC50 values of 19.2 μmol L, 27.9 μmol L, and 288 μmol L, respectively.

PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

EPO Mimetic Peptide-1 (EMP-1) is a 20 amino acid peptide that promotes cell proliferation, modulates the cell cycle, and stimulates reticulocyte production in vivo [1].

Shepherdin is a synthetic peptide mirroring amino acids 79-87 of human survivin, acting as an inhibitor of the survivin-heat shock protein 90 (Hsp90) interaction. It specifically targets the N-terminal domain of Hsp90, blocking the survivin-Hsp90 interaction in human reticulocyte extracts at a 150 µM concentration. Conjugates of Shepherdin with cell-permeable peptides, such as penetratin or the HIV Tat sequence, exhibit anticancer properties both in vitro and in vivo.

9-OxoODE, formed through the oxidation of the allylic hydroxyl group in both 9(S)-HODE and 9(R)-HODE, is present in rabbit reticulocyte plasma and mitochondrial membranes as both 9- and 13-oxoODEs, constituting approximately 2% of the total linoleate residues. The majority of these oxidized linoleate residues are esterified to membrane lipids.

Adustin is an antifungal antibiotic characterized as a polypeptide that inhibits translation. It effectively suppresses translation in a cell-free rabbit reticulocyte lysate system, exhibiting an IC50 of 0.34 μM.