resveratrol

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.

Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.

cis-Resveratrol ((Z)-Resveratrol) has antiviral activity, inhibits enteroviruses, increases TyrRS, promotes histone serine-ADP ribosylation-dependent DNA repair, and provides neuroprotection in a TyrRS-dependent manner.

DMU-212 is a methylated derivative of resveratrol with antimitotic, anti-proliferative, antioxidant, and apoptosis-promoting activities. It induces mitotic arrest, apoptosis, and activation of ERK1/2 protein and has oral activity[1][2]. DMU-212 (0.3125-40 μM) inhibits the growth of human melanoma cells (A375, MeWo, Bro, M5)[1]. At concentrations of 30-50 μM over 24 hours, it upregulates cell cycle inhibitors, induces apoptosis, and activates ERK in A375 cells[1]. DMU-212 also induces G2/M arrest and apoptosis in cancer cells[1]. In a xenograft model of human ovarian cancer with six-week-old SCID female mice (20-24 g), DMU-212 (50 mg/kg, administered orally three times a week for 14 days) inhibits tumor growth[2]. [1]. Vasilis Pericles Androutsopoulos, et al. Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells. Exp Dermatol. 2015 Aug;24(8):632-4. [2]. Hanna Piotrowska, et al. DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer. Biomed Pharmacother. 2014 May;68(4):397-400.

Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.

HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model

Resveratrol analog 1, an analog of Resveratrol, is a natural polyphenolic phytoalexin with antioxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

Resveratrol analog 2 is an analog of Resveratrol, a natural polyphenolic phytoalexin with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

4'-Acetoxy resveratrol is a derivative of Resveratrol. In human skin models, this compound enhances the gene expression of elastin, type III and IV collagen, superoxide dismutase (SOD), and catalase (CAT), while reducing the expression of interleukins (IL-1A, IL-1R2, IL-6, IL-8) and cyclooxygenase-2 (COX-2). It is applicable for skin research.

Resveratrol-4'-O-D-Glucuronide has anti-fat accumulation properties, is metabolized by resveratrol, and can be used in metabolism-related studies.

Azo-Resveratrol is an analog of Resveratrol used as a potent tyrosinase inhibitor.

Trans-Resveratrol-3-O-β-D-Glucuronide, an active metabolite of trans-resveratrol, inhibits the proliferation of various intestinal cancer cell lines. Additionally, this compound enhances pyruvate production in the liver [1] [2] [3].

cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects.

Resveratrol 4'-(6-galloylglucoside) (Resveratrol-4'-O-(6"-galloyl)glucoside) is a natural poduct found in the roots of rhubarb (Rheum palmatum L.).

TPP-resveratrol is a conjugate of Resveratrol and triphenylphosphine (TPP), noted for its anticancer activity. This compound enhances the efficacy of Resveratrol by facilitating its targeted delivery to mitochondria, thus inducing mitochondrial-mediated cell apoptosis (apoptosis).

4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)

C1 resveratrol is a novel multifunctional derivative of resveratrol, which is used to treat atrial fibrillation.

trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 μM, and induces apoptosis at concentrations of 25 and 50 μM. Resveratrol-3-O-sulfate also displaces rosiglitazone from the outer mitochondrial protein mitoNEET (IC50 = 3.36 μM for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.

Resveratrol-D4 is the deuterated form of Resveratrol. Resveratrol (T1558) (trans-Resveratrol; SRT501) is a naturally occurring polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It has a broad range of targets, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase. Resveratrol (T1558) is also a specific <

Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (T1558) (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol (T1558) is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.

(E/Z)-Resveratrol-13CN6 is the carbon-13 labeled form of Resveratrol- (4-Hydroxyphenyl).

Resveratrol (Standard) is the analytical standard of Resveratrol, primarily used for research and quantitative analysis. Resveratrol (trans-Resveratrol; SRT501) is a natural polyphenol with potent antioxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It interacts with a broad spectrum of targets, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase. Resveratrol is a specific SIRT1 activator that mimics the metabolic effects of caloric restriction. It also acts as a potent inhibitor of the Pregnane X Receptor (PXR) and an activator of Nrf2, ameliorating age-related renal injury.

(E/Z)-Resveratrol-13Cn6 (Standard) is a reference standard of (E/Z)-Resveratrol-13Cn6 intended for quantitative analysis, quality control, and related biochemical research applications. Resveratrol-(4-Hydroxyphenyl)-13CN6 is the carbon-13 labeled form of Resveratrol-(4-Hydroxyphenyl).