resveratrol

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.

Resveratrol analog 1, an analog of Resveratrol, is a natural polyphenolic phytoalexin with antioxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

Resveratrol analog 2 is an analog of Resveratrol, a natural polyphenolic phytoalexin with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

Resveratrol-4'-O-D-Glucuronide has anti-fat accumulation properties, is metabolized by resveratrol, and can be used in metabolism-related studies.

Azo-Resveratrol is an analog of Resveratrol used as a potent tyrosinase inhibitor.

Trans-Resveratrol-3-O-β-D-Glucuronide, an active metabolite of trans-resveratrol, inhibits the proliferation of various intestinal cancer cell lines. Additionally, this compound enhances pyruvate production in the liver [1] [2] [3].

Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.

cis-Resveratrol ((Z)-Resveratrol) has antiviral activity, inhibits enteroviruses, increases TyrRS, promotes histone serine-ADP ribosylation-dependent DNA repair, and provides neuroprotection in a TyrRS-dependent manner.

cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects.

4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)

trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

(E/Z)-Resveratrol-13Cn6 (Standard) is a reference standard of (E/Z)-Resveratrol-13Cn6 intended for quantitative analysis, quality control, and related biochemical research applications. Resveratrol-(4-Hydroxyphenyl)-13CN6 is the carbon-13 labeled form of Resveratrol-(4-Hydroxyphenyl).

Resveratrol 12-C-β-glucopyranoside is a natural product exhibiting antioxidant activity against DPPH (IC50=70.47 mg/L).

DMU-212 is a methylated derivative of resveratrol with antimitotic, anti-proliferative, antioxidant, and apoptosis-promoting activities. It induces mitotic arrest, apoptosis, and activation of ERK1/2 protein and has oral activity[1][2]. DMU-212 (0.3125-40 μM) inhibits the growth of human melanoma cells (A375, MeWo, Bro, M5)[1]. At concentrations of 30-50 μM over 24 hours, it upregulates cell cycle inhibitors, induces apoptosis, and activates ERK in A375 cells[1]. DMU-212 also induces G2/M arrest and apoptosis in cancer cells[1]. In a xenograft model of human ovarian cancer with six-week-old SCID female mice (20-24 g), DMU-212 (50 mg/kg, administered orally three times a week for 14 days) inhibits tumor growth[2]. [1]. Vasilis Pericles Androutsopoulos, et al. Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells. Exp Dermatol. 2015 Aug;24(8):632-4. [2]. Hanna Piotrowska, et al. DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer. Biomed Pharmacother. 2014 May;68(4):397-400.

Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.

HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model

Resveratrol 4'-(6-galloylglucoside) (Resveratrol-4'-O-(6"-galloyl)glucoside) is a natural poduct found in the roots of rhubarb (Rheum palmatum L.).

TPP-resveratrol is a conjugate of Resveratrol and triphenylphosphine (TPP), noted for its anticancer activity. This compound enhances the efficacy of Resveratrol by facilitating its targeted delivery to mitochondria, thus inducing mitochondrial-mediated cell apoptosis (apoptosis).

C1 resveratrol is a novel multifunctional derivative of resveratrol, which is used to treat atrial fibrillation.

Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 μM, and induces apoptosis at concentrations of 25 and 50 μM. Resveratrol-3-O-sulfate also displaces rosiglitazone from the outer mitochondrial protein mitoNEET (IC50 = 3.36 μM for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.

Resveratrol-d4 is the deuterated form of Resveratrol. Resveratrol (trans-Resveratrol; SRT501) is a naturally occurring polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It has a broad range of targets, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase. Resveratrol is also a specific <

Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.

Resveratrol-(4-Hydroxyphenyl)-13CN6 is the carbon-13 labeled form of Resveratrol-(4-Hydroxyphenyl).

Resveratrol (Standard) is a reference standard for research and analysis in studies involving Resveratrol. Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.