qc

QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).

QC-01-175 is a heterobifunctional small molecule specifically designed to induce degradation of aberrant tau protein, and it effectively reduces levels of A152T and P301L mutant tau, protects neurons from tau-mediated cytotoxicity. QC-01-175 significantly improves neuronal survival, thereby providing a valuable chemical biology tool for studying tauopathies and developing targeted protein degradation strategies for neurodegenerative diseases.

Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.

QC-308 HCl is a novel Heme Oxygenase-1 Inhibitor (HO-1 IC50=0.27μM; HO-2 IC50=0.46μM).

QC-124 is a PROTAC degrader specifically targeting p300/CBP.

Zavondemstat (QC8222 free base) is a histone lysine demethylase 4 (KDM4) inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.

Vidofludimus hemicalcium (4sc-101; SC12267) is an orally active compound that acts as a dihydroorotate dehydrogenase (DHODH) inhibitor and serves as a novel modulator of the farnesoid X receptor (FXR). This immunomodulatory agent is utilized in the research of autoimmune disorders, including inflammatory bowel disease (IBD), and is explored for its potential in fatty liver disease research through FXR targeting.

QC-182 is a potent p300/CBP PROTAC degrader. It reduces p300 protein levels in SK-HEP-1 cells with a DC50 of 93 nM. QC-182 effectively inhibits cell growth in SK-HEP-1 and JHH7 cell lines, with IC50 values of 0.733 μM and 0.477 μM, respectively. QC-182 is applicable for hepatocellular carcinoma (HCC) research.

QC-125 is a PROTAC degrader specifically targeting p300/CBP.

PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease.

QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).

BQCA (benzylquinolone carboxylic acid) a highly selective allosteric M1 mAChR modulator.

3-AQC is a competitive antagonist of 5-HT3.

Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].

QCC-374 is a prostanoid agonist. It potentially for the treatment of pulmonary arterial hypertension.

HQCG is an inhibitor of 2- Oxoglutarate- dependent nucleic acid demethylase that also acts as a prolyl- 4- hydroxylase inhibitor.

Liqcoumarin belongs to the hydroxycoumarin class. Within cells, it is primarily located in the cytoplasm. Outside the human body, it can be found in herbs, spices, and teas. This makes Liqcoumarin a potential biomarker of consumption of these foods.

2-APQC is a selective, orally active Sirtuin-3 (SIRT3) agonist (Kd=2.756 μM) that modulates mitochondrial homeostasis. It attenuates ISO-induced myocardial hypertrophy and fibrosis in vivo and in vitro, making it suitable for heart failure research. 2-APQC inhibits mTOR-p70S6K, JNK, TGF-β/Smad3, and ROS-p38MAPK pathways while activating PYCR1 and AMPK-Parkin, thereby suppressing necrosis and mitigating mitochondrial oxidative damage.

TQC2731 is a fully human monoclonal antibody that targets TSLP. It can be utilized for research on asthma and other related diseases mediated by Th2 inflammation.

TQC2938 is a humanized IgG2 monoclonal antibody inhibitor that targets stimulating factor-2 (ST2). It blocks the ST2/IL-33 signaling pathway, reducing downstream Th2 cytokines (such as IL-4, IL-5, and IL-13) and levels of eosinophils and other inflammatory cells. TQC2938 is applicable for research in inflammatory diseases like asthma.

Qca-Methylester-D3 (Standard) is a reference standard of Qca-Methylester-D3 intended for quantitative analysis, quality control, and related biochemical research applications.

MC-Sq-Cit-PAB-Dolastatin10 is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), incorporating Dolastatin10 (a tubulin polymerization inhibitor) connected via the MC-Sq-Cit-PAB ADC linker.

MC-Sq-Cit-PAB-Gefitinib is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Gefitinib—an EGFR tyrosine kinase inhibitor—connected through the MC-Sq-Cit-PAB ADC linker.

Zavondemstat (L-lysine) (QC8222; TACH 101) is an inhibitor of the histone lysine demethylase 4D (KDM4D) with antitumor properties.