protein storage

Edetic acid (Ethylenediaminetetraacetic acid) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.

IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein disease, polyglutamine and polyalanine diseases, leukodystrophy, cystic fibrosis, multiple sclerosis, lysosome storage disorders, amyloidosis diseases, inflammation, metabolic disorders, cardiovascular diseases, osteoporosis, neurological trauma, and more.

DL-Selenomethionine (Seleno-DL-methionine) is a selenium (Se) analogue of methionine in which sulfur is replaced with the trace element selenium. Selenomethionine (SeMet) can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible Se storage in organs and tissues.

EDTA tetrasodium tetrahydrate is a metal chelator known for its ability to bind with divalent and trivalent metal cations, including calcium. It exhibits antihypercalcemic and anticoagulant properties. This compound reduces metal ion-catalyzed oxidative damage to proteins and maintains a reducing environment during protein purification processes, making it commonly used for protein purification and storage. Additionally, it helps in minimizing the formation of disulfide bonds.

N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine enhances β-glucocerebrosidase (β-Glucocerebrosidase) activity by 20%. It is used in research on lysosomal storage disorders and other protein accumulation diseases.

C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.

Cy5.5-SE (Cyanine5.5 NHS ester) DIPEA, a cyanine (CY) dye, comprises two nitrogen atoms linked by an odd number of methyl units. Characterized by long wavelength, tunable absorption and emission, high extinction coefficient, and good water solubility, alongside relatively straightforward synthesis [1], CY dyes are frequently utilized for labeling proteins, antibodies, and small molecular compounds. Their application in protein antibody labeling is achieved through a simple mixing reaction, providing a method of notable reference significance [2]. Storage instructions include protection from light.

Ethylenediaminetetraacetic acid-d12 is the deuterated form of Ethylenediaminetetraacetic acid. Ethylenediaminetetraacetic acid (EDTA) serves as a metal chelator, binding with divalent and trivalent metal cations, including calcium. It exhibits antihypercalcemic and anticoagulant properties, reduces metal ion-catalyzed oxidative damage to proteins, and maintains a reducing environment during protein purification. EDTA is commonly used in protein purification and storage and helps minimize the formation of disulfide bonds.

Myoglobin is a small pigment protein composed of globin and heme (Heme), capable of reversibly binding with oxygen to form MbO2, known as oxy-myoglobin, while Mb refers to deoxy-myoglobin. Within muscle cells, myoglobin plays a role in the transport and storage of oxygen.

Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a metal chelator that binds with divalent and trivalent metal cations, including calcium. It exhibits antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemic, and anticoagulant properties. EDTA sodium hydrate reduces protein oxidation damage catalyzed by metal ions and maintains a reducing environment during protein purification, making it a common choice for protein purification and storage. Additionally, it can alleviate liver fibrosis and is used in research related to coronary artery disease and neurological disorders.

L-Histidine buffer (Sterile) is a widely used antibody-storage formulation containing 20 mM L-Histidine, 240 mM sucrose, 150 mM NaCl, and 0.05% Tween-80 at pH 5.8. L-Histidine buffer (Sterile) supports long-term protein stability by providing osmoprotection, isotonicity, and controlled acidity, making it suitable for monoclonal antibody preservation and biologics development.