pressure-lowering

Taurine (2-Aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues and is one of the constituents of bile acids. Taurine is involved in a number of processes related to energy expenditure and muscle function, and can treat fatigue and muscles as well as improve immune function.

Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Omidenepag isopropyl (DE-117) is a selective prostaglandin EP2 receptor agonist and a novel topical ocular blood pressure lowering compound.Omidenepag isopropyl has a weak affinity for EP1, EP2, and FP receptors.Omidenepag isopropyl is used in studies of glaucoma and hypertension. Omidenepag isopropyl can be used to study glaucoma and hypertension.

Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist that acts as a hypoglycemic agent by lowering blood glucose levels and increasing blood pressure in vivo.

Catharanthine Tartrate is a natural product isolated from Madagascar periwinkle, Catharanthine Tartrate inhibits voltage-operated L-type Ca2+ channel, with anti-cancer and blood pressure-lowering activity

Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and steviolbioside, have many biological activities, such as reducing blood glucose, lowering blood pressure, anti-inflammation, anti-tumor, anti-diarrhea, antibacterium, immunoregulation, etc.

Veratric acid (3,4-Dimethoxybenzoic acid) is a benzoic acid derivative from plants and fruits, possessing antioxidant, anti-inflammatory, and blood pressure-lowering properties.

Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.

Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway. Latanoprost acid can be used in studies about lowering pressure inside the eyes.

Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.

1,4-Dihydropyridine acts as an antagonist for calcium channels (calcium channel), specifically blocking the L-type calcium channels. This action reduces the influx of calcium ions into cardiac and vascular smooth muscle cells, consequently decreasing cardiac contractility and heart rate, dilating blood vessels, and lowering blood pressure.

Dropempine (Abdoman) is a ganglionic blocker with pharmacological effects that include lowering blood pressure and providing anti-ulcer benefits.

Tipentosin, a derivative of prazosin, acts as an angiotensin-converting enzyme inhibitor. This compound was developed for its blood pressure-lowering properties.

Trimoxamine is a compound known for its blood pressure-lowering effects.

Research indicates that Biclodil is a vasodilator with blood pressure-lowering effects.

CGS-24592 is an orally active, selective, and potent inhibitor of neutral endopeptidase 24.11 (NEP), with an IC50 value of 1.6 nmol/L. It reduces the degradation of atrial natriuretic peptide (ANP), thereby increasing plasma ANP concentration and lowering blood pressure. CGS-24592 shows potential for research in cardiovascular diseases such as hypertension and congestive heart failure.

ent-Levobunolol (hydrochloride) ((R)-Bunolol (hydrochloride)) is a competitive β-adrenergic receptor blocker. It functions by inhibiting the transmission of sympathetic nerve impulses, reducing the production of aqueous humor, and constricting blood vessels within the eye, thereby lowering intraocular pressure. This compound shows potential for research in conditions like glaucoma and other ocular hypertension disorders.

Bimatoprostcyclohexyl amide (N-Cyclohexyl-desamethyl bimatoprost; 17-Phenyl trinor prostaglandin F2α cyclohexyl amide) is an analogue of Bimatoprost. This compound acts as an agonist of the prostaglandin F2α receptor (FP receptor) and can be utilized for research in lowering intraocular pressure and in studies of glaucoma.

SB772077B is a ROCK inhibitor with anti-inflammatory properties. It boosts aqueous humor outflow (OF) by inhibiting the RhoA/ROCK signaling pathway. This compound significantly reduces mRNA levels of β-catenin and protein levels of fibrosis markers such as vinculin, fibronectin, collagen1 A, and vimentin. Additionally, SB772077B exhibits vasodilatory effects, lowering both pulmonary arterial and systemic blood pressure. It is useful for research on glaucoma and pulmonary arterial hypertension.

Atiprosine (AY-28228) is an orally active and selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. It also exhibits antagonist activity against α2-adrenergic receptors, 5-HT₂ receptors, and H₁ receptors, with pA2 values of 6.04, 6.87, and 7.32 respectively. Atiprosine is effective in reducing hypertension and lowering blood pressure in rats, dogs, and monkeys. It is utilized in cardiovascular and mental disorder research.

CAII-IN-11 (Compound A1) is a dual-targeted compound that includes an hCA II inhibitor segment (IC₅₀= 2 nM) and a NO donor component. It also shows inhibitory activity against hCA IX, hCA XII, and hCA I, with IC₅₀ values of 6, 3, and 152 nM, respectively. CAII-IN-11 significantly elevates cGMP levels in human trabecular meshwork cells. Furthermore, it reduces apoptosis of retinal ganglion cells by decreasing oxidative stress (ROS levels), inhibiting astrocytes, and NLRP3 inflammasome activation. In a rabbit model, CAII-IN-11 demonstrates intraocular pressure-lowering activity, making it a potential candidate for glaucoma research.

H-0104 Dihydrochloride is an inhibitor of ROCK that acts by applying potent intraocular pressure (IOP)-lowering effects into the eyes of monkeys.

H-0106 Dihydrochloride is an inhibitor of ROCK that acts by applying strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys.

A 81282 is a selective antagonist of angiotensin receptors. It has the activity of lowering blood pressure.