pressure-lowering — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0106	Methazolamide	L584601,CL 8490	Carbonic Anhydrase
	Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.		Carbonic Anhydrase
T12478L	Pinacidil	S 1230,P 1134,S-1230,P-1134,P1134	Potassium Channel
	Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.		Potassium Channel
T4661	PKG drug G1		PKA
	PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.		PKA
T15718	Latanoprost acid		GPR
	Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway. Latanoprost acid can be used in studies about low...		GPR
T26453	A 81282	A81282,A-81282,Abbott 81282,Abbott-81282
	A 81282 is a selective antagonist of angiotensin receptors. It has the activity of lowering blood pressure.
T25483	H-0106 Dihydrochloride	H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride
	H-0106 Dihydrochloride is an inhibitor of ROCK that acts by applying strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys.
T25482	H-0104 Dihydrochloride	H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl
	H-0104 Dihydrochloride is an inhibitor of ROCK that acts by applying potent intraocular pressure (IOP)-lowering effects into the eyes of monkeys.
T81915	LPP Tripeptide
	LPP Tripeptide, a blood pressure-lowering tripeptide, is utilized in hypertension research [1].
T0112L	Diltiazem	Diltiazem free base,Dilticard,CRD-401,CRD401,Dilzen,CRD 401
	Diltiazem is a non-dihydropyridine (non-DHP) calcium channel blocker that relaxes the smooth muscle in arterial walls, thus opening (dilating) arteries, allowing easier blood flow, and lowering blood pressure, and is use...
T76499	Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine
	Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine, is a peptide composed of 4 amino acids recognized for its blood pressure-lowering properties and functions as an angiotensin-converting enzyme (ACE) inhibitor. This...
T68098	Midaglizole	(±)-DG5128 free base,DG5128 free base,(±)-DG5128 free base ; DG5128 free base
	Midaglizole ((±)-DG5128 free base, DG5128 free base) is a powerful α2-adrenoceptor antagonist that acts as a hypoglycemic agent by increasing blood pressure and lowering blood glucose levels in vivo.
T39063	Azilsartan mepixetil
	Azilsartan mepixetil is a potent angiotensin II receptor antagonist with enhanced efficacy and prolonged duration of action. It exhibits more prominent and sustained effects in lowering blood pressure and heart rate, whi...
T16388	Omidenepag isopropyl		Prostaglandin Receptor
	Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, an...		Prostaglandin Receptor
T78624	OPC-163493		Reactive Oxygen Species
	OPC-163493 is an orally active, liver-targeted mitochondrial uncoupling agent that diminishes Δψ (delta psi) and mitochondrial ROS (reactive oxygen species) production. This compound demonstrates antidiabetic properties ...		Reactive Oxygen Species
T72213	Efonidipine hydrochloride	NZ-105 hydrochloride
	Efonidipine HCl (NZ-105) serves as both a T-type and L-type calcium channel blocker. This compound, distinct from other calcium channel blockers, notably increases N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate...

Compounds

Methazolamide

T0106

Synonym: L584601,CL 8490

Target: Carbonic Anhydrase

Pinacidil

T12478L

Synonym: S 1230,P 1134,S-1230,P-1134,P1134

Target: Potassium Channel

Synonym: A81282,A-81282,Abbott 81282,Abbott-81282

Target:

H-0106 Dihydrochloride

T25483

Synonym: H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride

Target:

H-0104 Dihydrochloride

T25482

Synonym: H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl

Synonym: Diltiazem free base,Dilticard,CRD-401,CRD401,Dilzen,CRD 401

Target:

Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine

Synonym: (±)-DG5128 free base,DG5128 free base,(±)-DG5128 free base ; DG5128 free base

Target: Prostaglandin Receptor

OPC-163493

T78624

Synonym:

Target: Reactive Oxygen Species

Efonidipine hydrochloride

T72213

Synonym: NZ-105 hydrochloride

Target:

Cat No.	Product Name	Synonyms	Targets
T0022	Taurine	2-Aminoethanesulfonic acid	LDL , Endogenous Metabolite , Autophagy
	Taurine (2-Aminoethanesulfonic acid), an organic acid, is distributed in various animal tissues.		LDL , Endogenous Metabolite , Autophagy
T6S0654	Isocorynoxeine	7-Isocorynoxeine	5-HT Receptor
	1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ...		5-HT Receptor
T2782L	Catharanthine Tartrate(2468-21-5(free base))		Calcium Channel
	Catharanthine Tartrate is a natural product isolated from Madagascar periwinkle, Catharanthine Tartrate inhibits voltage-operated L-type Ca2+ channel, with anti-cancer and blood pressure-lowering activity		Calcium Channel
T3744	Veratric acid	Veratrumenoic acid,3,4-Dimethoxybenzoic acid	Reactive Oxygen Species , COX
	Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects.		Reactive Oxygen Species , COX
T3332	Isosteviol	(-)-Isosteviol	IL Receptor , Potassium Channel , TNF , NF-κB , Reactive Oxygen Species , COX , Topoisomerase
	Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and stevio...
TN2350	Pingpeimine A		Others
	Pingpeimine A has the effect of expectorating and lowering blood pressure. Derived from Fritillaria sibiricum.		Others