pfkfb3

PFKFB3-IN-2 is an inhibitor of 6-phosphofructo-2-kinase fructose-2,6-bisphosphatase 3 (PFKFB3). Anti-sense treatment against PFKFB3 has demonstrated a reduction in tumor growth rate in vivo.

AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.

AZ-PFKFB3-67 quarterhydrate is a selective and potent inhibitor of the metabolic kinase PFKFB3 kinase, acting on PFKFB3 (IC50: 11 nM), PFKFB2 (IC50: 159 nM) and PFKFB1 (IC50: 1130 nM).

AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with an IC50=11nM for PFKFB3, reduces MCL-1, and inhibits angiogenesis by decreasing lactic acid production and ATP levels in endothelial cells (ECs) in tube-forming assays, and has neuroprotective effects.

(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase fructose-2, 6-bisphosphatase) inhibitor.

PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).

PFK-158 is an effective and specific inhibitor PFKFB3.

KAN0438757 is a selective and potent inhibitor of the metabolic kinase [PFKFB3] with an IC50 of 0.19 μM.

YN1 is an inhibitor of PFKFB3.

3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decreases the intracellular concentration

Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, acting as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].