oleic

Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 μg/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 μM, similar to arachidonic acid .3 Oleic acid (60 μM) induces release of intracellular calcium in human platelets.4

Oleic acid-d2 is the deuterated form of oleic acid. Oleic Acid (9-cis-Octadecenoic acid) is the most prevalent monounsaturated fatty acid found in human adipose tissues and other structures. Additionally, Oleic Acid acts as a Na+/K+ ATPase activator.

Oleic acid-d9 is the deuterated form of Oleic acid. Oleic acid, predominantly found in human adipose tissue and other tissues, is the most common monounsaturated fatty acid. It serves as an activator of Na+/K+ ATPase.

Oleic acid-d17 is the deuterated form of Oleic acid. Oleic acid, also known as 9-cis-Octadecenoic acid, is the most prevalent monounsaturated fatty acid found in human adipose tissue and other tissues. It serves as an activator of Na+/K+ ATPase.

Oleic acid-13C18 is the 13C-labeled version of oleic acid. Oleic acid (9-cis-Octadecenoic acid) is the most prevalent monounsaturated fatty acid found in human adipose tissue and other tissues. It acts as an activator of the Na+/K+ATPase enzyme.

Deulinoleic acid is a lipid peroxidation inhibitor and antioxidant.

Palmitoleic acid-13C16 is a 13C-labeled variant of Palmitoleic acid. As a constituent of fatty acids, Palmitoleic acid helps prevent death caused by cerebrovascular diseases in SHRSP rats.

Palmitoleic acid-d14 is a deuterated form of Palmitoleic acid. As a component of fatty acids, Palmitoleic acid can prevent death caused by cerebrovascular diseases in SHRSP rats.

Linoleic acid-d5 is the deuterated form of Linoleic acid. Linoleic acid is a common polyunsaturated fatty acid (PUFA) found in vegetable oils, nuts, and seeds. It is part of membrane phospholipids, contributing as a structural component to maintain epidermal transdermal water barriers. Linoleic acid can induce damage to erythrocytes and hemoglobin through oxidation.

Linoleic acid-13C1 is a 13C-labeled form of linoleic acid, a widely found polyunsaturated fatty acid (PUFA) present in plant oils, nuts, and seeds. As a component of membrane phospholipids, linoleic acid contributes to membrane fluidity and supports the transdermal water barrier of the epidermis. Its oxidation can lead to the damage of red blood cells and hemoglobin.

Linoleic Acid-d4 is the deuterated form of Linoleic acid. Linoleic acid is a common polyunsaturated fatty acid (PUFA) found in plant oils, nuts, and seeds. It is part of membrane phospholipids and acts as a structural component to maintain the epidermal transdermal water barrier. Additionally, Linoleic acid can cause oxidative damage to red blood cells and hemoglobin.

Palmitoleic acid-d13 is the deuterated form of Palmitoleic acid. Palmitoleic acid, a component of fatty acids, has the potential to prevent death from cerebrovascular diseases in SHRSP rats.

1,2-Dioleoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2-dioleoyl-rac-glycerol by GC- or LC-MS. 1,2-dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at the sn-1 and sn-2 positions. It effectively binds the C1 domain to activate conventional protein kinase C forms and serves as a substrate for diacylglycerol kinases and multisubstrate lipid kinase.1,2,3 |1. Yamaguchi, Y., Shirai, Y., Matsubara, T., et al. Phosphorylation and up-regulation of diacylglycerol kinase γ via its interaction with protein kinase Cγ. J. Biol. Chem. 281(42), 31627-31637 (2006).|2. Zhou, Q.Z., Raynor, R.L., Wood, M.G., Jr., et al. Structure-activity relationship of synthetic branched-chain distearoylglycerol (distearin) as protein kinase C activators. Biochemistry 27(19), 7361-7365 (1988).|3. Epand, R.M., Shulga, Y.V., Timmons, H.C., et al. Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase. Biochemistry 46(49), 14225-14231 (2007).

Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of endogenous lipids whose levels are modulated by fasting and high-fat diets, and they play a role in insulin sensitivity. These compounds consist of a fatty acid—either a C-16 or C-18, such as palmitoleic, palmitic, oleic, or stearic acid—esterified to a hydroxylated C-16 or C-18 lipid. One notable FAHFA, 9-PAHSA, features an ester linkage between palmitic acid and 9-hydroxy stearic acid. PAHSAs, with 9-PAHSA being the most prevalent isomer, are significantly found in the serum and both white and brown adipose tissues of glucose-tolerant AG4OX mice, which express the Glut4 gene in adipose tissue, enhancing insulin sensitivity. Additionally, 9-PAHSA is abundant in wild type and AG4OX mice and present in humans, though at reduced levels in those with insulin resistance. 9-PAHSA is associated with improved glucose tolerance, enhanced insulin secretion, and anti-inflammatory effects in mice. The compound 19-PAHSA^13C4 represents an isotopically enriched form of this polyunsaturated fatty acid.

1,2-Dioleoyl-3-lauroyl-rac-glycerol-13C3 is designed as an internal standard for the quantification of 1,2-dioleoyl-3-lauroyl-rac-glycerol, employable with GC- or LC-MS techniques. This compound is a type of triacylglycerol featuring oleic acid at the sn-1 and sn-2 positions, and lauric acid at the sn-3 position, and has been identified in date seed oil and the fat body of male B. lapidarius bumblebees.

Azelaic acid-d14 is the deuterated form of Azelaic acid. Azelaic acid is an organic compound produced through the ozonolysis of oleic acid and is used as a component in hair and skin conditioning agents.