negative

The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5.

ELA-14 negative control is an inactive peptide that serves as a negative control for ELA-14.

BING, a antimicrobial peptide discovered in Japanese medaka fish (O. laptipes), originates from vacuolar protein sorting-associated protein 13D-like (Vps13D). It exhibits efficacy against a range of Gram-negative and Gram-positive bacteria, notably including methicillin-resistant S. aureus (MRSA; MICs = 4-64 µg/ml). Furthermore, BING enhances the effectiveness of antibiotics such as ampicillin, amoxicillin, and novobiocin against P. aeruginosa, and it prevents resistance development to kanamycin and ampicillin in E. coli. Notably, its administration in vivo significantly improves survival rates in O. laptipes challenged with E. tarda.

ZIP (SCRAMBLED) Acetate (ZIP (SCRAMBLED) Acetate (908012-18-0 Free Base)) is a scrambled peptide that can be used as a negative control for zeta inhibitory peptide (ZIP).

CysHHC10 acetate shows antibacterial activities against both Gram-positive and Gram-negative bacteria with MIC of 10.1, 20.2, 2.5, and 1.3 mM for E. coli, P. aeruginosa, S. aureus, and S. epidermidis, respectively.

Colistin-1,3,5,9-tetramethanesulfonic A acid is used for the treatment of serious infections due to selected aerobic Gram-negative pathogens in patients with limited treatment options.

Magainin 1 acetate is an antimicrobial peptide. Magainin 1 acetate exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.

SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.

RLLFT-NH2 acetate is a reversed amino acid sequence negative control peptide for TFLLR-NH2.

Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1. Tat-beclin 1 acetate decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1).

Polymyxin B nonapeptide acetate is a cationic cyclic peptide. Polyxin B nonapeptide is a derivative produced by enzymatic cleavage of polyxin B. Compared with polyxin B, polyxin B nonapeptide has low toxicity, lacks bactericidal activity and still has the

Thiostrepton (Alaninamide) is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.

Polymyxin B Sulfate (Poly-RX) is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B Sulfate (Poly-RX) is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probab

PBP10, a cell-permeable and selective gelsolin-derived peptide, inhibits formyl peptide receptor 2 (FPR2) over FPR1 [1]. This 10-amino acid (AA) peptide features a rhodamine conjugation at its N terminus, exhibiting bactericidal activity against both gram-positive and gram-negative bacteria while mitigating microbial-induced inflammatory effects [2].

Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).

Colistin A is an antibiotic generated by certain strains of the bacteria Paenibacillus polymyxa. Colistin is a mixture of the cyclic polypeptides colistin A and B and belongs to the class of polypeptide antibiotics known as polymyxins. Colistin is effecti

Bradykinin analog nonapeptide. Reverse sequence of Bradykinin (Cat.No. 3004). Exhibits no significant kinin activity. Can be used as a negative control. Lande (1962) Retrobradykinin: a peptide with the reverse sequence of bradykinin. J.Org.Chem. 27 4558

Human β-defensin-2 (HβD-2) is a cationic skin-antimicrobial peptide (SAP) characterized by its small size and rich cysteine content. It is produced by various epithelial cells and exhibits potent antimicrobial properties against gram-negative bacteria and Candida. However, it does not effectively target gram-positive Staphylococcus aureus. Given these characteristics, Human β-defensin-2 serves as a valuable tool in colitis research.

Scrambled TRAP Fragment is a variant of the TRAP Fragment compound, characterized by its random amino acid sequence. It is typically employed as a negative control due to its similarity in composition to the active fragment.

Darobactin is an antibiotic effective against critical Gram-negative pathogens, demonstrating activity both in vitro and in animal infection models [1].

SPR741, formerly NAB741 (12), is a cationic peptide derived from polymyxin B and is one such potentiator molecule that is under development for the treatment of serious Gram-negative bacterial infections.

CRAMP-18 (mouse) is an antibiotic peptide with demonstrated efficacy against Gram-negative bacteria, including S. typhimurium and P. aeruginosa, while exhibiting no hemolytic activity. This compound shows promise for research into antifungal, antibacterial, and antitumor applications [1] [2].

Cecropin D, an antimicrobial peptide, exhibits a minimum inhibitory concentration (MIC) of 4.55 μg/mL and demonstrates efficacy against both Gram-negative and Gram-positive bacteria. Additionally, it possesses antiviral, antifungal, antitumor, and immunomodulatory properties [1] [2].

BNC210 (IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.

Crotalicidin, obtained from rattlesnake venom, is both an antimicrobial and anti-tumor peptide with potent efficacy against Gram-negative bacteria and cancerous cells, showing promise for research in microbial infections and oncology [1].

Pyrrhocoricin is a bioactive peptide exhibiting antimicrobial activity against Gram-negative bacteria.

SMAP-18, an 18-amino acid residue peptide amide, is a biologically active truncated variant of Sheep myeloid antimicrobial peptide-29 (SMAP-29). It retains potent antimicrobial activity against Pseudomonas strains, other Gram-negative bacteria, and multidrug-resistant pathogens. Notably, SMAP-18 exhibits increased cell selectivity relative to the parent peptide SMAP-29 due to its reduced hemolytic activity while maintaining its antimicrobial efficacy.

K4 peptide exhibits potent antimicrobial properties, effectively targeting both Gram-positive and Gram-negative bacteria, particularly pathogenic strains like Staphylococcus aureus and Marine Vibrio species [1].

CysHHC10 TFA, a synthetic antimicrobial peptide (AMP), demonstrates potent effectiveness against a broad spectrum of bacteria, including both Gram-positive and Gram-negative strains. Specifically, Minimum Inhibitory Concentration (MIC) values for CysHHC10 TFA are determined to be 10.1 mM against E. coli, 20.2 mM against P. aeruginosa, 2.5 mM against S. aureus, and 1.3 mM against S. epidermidis, highlighting its potential as a versatile antimicrobial agent [1].

SPR741 TFA (NAB741 TFA), a cationic peptide derived from polymyxin B, acts as a potentiator molecule that enhances the permeability of Gram-negative bacteria's outer membrane, thereby facilitating the treatment of severe Gram-negative bacterial infections. This compound effectively inhibits multidrug-resistant Gram-negative bacteria and, when combined with antibiotics, broadens their spectrum of activity [1] [2].

MDP1, derived from Melittin, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria, leading to bacterial death through membrane damage. This compound exhibits potent antibacterial activity against multidrug-resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa [1].

Compound 9C [c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]] demonstrates broad-spectrum efficacy against drug-resistant Gram-positive and Gram-negative bacteria. It exhibits minimum inhibitory concentrations (MICs) of 3.1 μg/mL for MRSA (ATCC BAA-1556), 3.1 μg/mL for S. aureus (ATCC 29213), 12.5 μg/mL for P. aeruginosa (ATCC 27883), and 25 μg/mL for E. coli (ATCC 25922) [1].

Hepcidin-20 (human), a peptide characterized by its histidine content, cysteine-rich composition, and β-sheet structure, exhibits antifungal properties. Furthermore, it effectively inhibits biofilm formation and disrupts the metabolism of bacterial cells in both polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains [1] [2] [3].

Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide that exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative aerobic bacteria, in addition to antimalarial properties. Notably, it does not possess the adverse hemolytic effects commonly associated with bee venom peptides [1].

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), acts as a negative modulator of TRH's cholinergic effect in the mouse brain, significantly reducing TRH-induced release of extracellular acetylcholine in the hippocampus. Resistant to metabolism by thyroliberinase, (Glu2)-TRH exhibits neuroprotective, antidepressant, and anticonvulsant properties in the CNS [1].

CAP18 (rabbit) is a 37 amino acid antimicrobial peptide derived from rabbit granulocytes. It exhibits extensive antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. Thus, CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research.

LL-37 scrambled peptide acetate is a scrambled peptide of cathepsin antimicrobial peptide LL-37, which is often used as a negative control for LL-37 peptide in experiments.

Tat-peptide 168-189, a cell-permeable, Tat-labeled fusion peptide derived from residues 168-189 of rat G3BP1, features the HIV Tat sequence at its least conserved terminus to enhance cellular uptake. It serves as the negative control for Tat-peptide 168-189 TFA, which promotes axon growth and neurite proliferation [1].

LMW peptide, an antimicrobial peptide, exhibits activity against both Gram-positive and Gram-negative bacteria, including B. subtilis, L. monocytogenes, E. coli, P. aeruginosa, and V. cholera [1].

Dermaseptin-B3 is an antimicrobial peptide that exhibits inhibitory effects against both Gram-positive and Gram-negative bacterial strains, with minimum inhibitory concentrations (MICs) of 1.3, 2.3, 5.0, 2.6, and 2.3 μM for S. aureus, P. aeruginosa, E. (ATCC 25922), and E. (54127) respectively. Additionally, this compound demonstrates antiproliferative activity against tumor cells [1] [2].

DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer [1].

Gramicidin S (Gramicidin Soviet), a cationic cyclic peptide antibiotic, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria and inhibits cytochrome bd quinol oxidase [1].

CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria.

Colistin A sulfate hydrate, a key constituent of the polymyxin antibiotic Colistin, effectively combats infections from challenging gram-negative bacteria [1].

Buforin II, a powerful antimicrobial peptide originating from Buforin I (a protein extracted from the Asian toad Bufo bufo gargarizans's stomach), exhibits broad-spectrum antimicrobial properties against both Gram-positive and Gram-negative bacteria [1].

MDP1 acetate, a derivative of Melittin, compromises the membrane integrity of both Gram-positive and Gram-negative bacteria leading to bacterial death through membrane damage. It exhibits potent antibacterial activity against multidrug-resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa [1].

Pseudin-2, an antimicrobial peptide (AMP) isolated from the skin of the South American paradoxical frog (Pseudis paradoxa), demonstrates a potent inhibitory effect on the growth of Gram-negative bacteria [1].

ND1-YL2 is a peptide-based PROTAC®Degrader of steroid receptor co-activator 1 (SRC-1; also known as nuclear receptor coactivator 1, NCOA1). ND1-YL2 is composed of a stapled peptide that binds SRC-1 (YL2) joined by a linker to a tetrapeptide that binds UBR box domains. Upon ternary complex formation, SRC-1 is polyubiquitinated and subsequently degraded via the N-degron pathway. This Degrader induces dose-dependent degradation of SRC-1 in the MDA-MB-231 triple negative breast cancer cell line (DC50 = 10 μM), and binds to the PAS-B domain of SRC-1 (Ki = 320 nM). ND1-YL2 inhibits MDA-MB-231 cell migrationin vitro, and suppresses metastasis of MDA-MB-231 cellsin vivo.

IDR-1 is an antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.