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Search Results for " necrostatin "

11

Compounds

Cat No. Product Name Synonyms Targets
T7504 Necrostatin 2 racemate Necrostatin-2 racemate RIP kinase
Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.
T1847 Necrostatin-1 Nec-1,Necrostatin 1 Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
T25859 Necrostatin-7 Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7 Apoptosis
Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts.
T37558 Necrostatin-5 Nec-5 RIP kinase , Necroptosis
Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM.
T9095 Necrostatin-34 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 RIP kinase
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
T68520 Cl-Necrostatin-1
Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase. It inhibits RIPK1 activity.
T12203L Necrostatin 2 Others
Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.
T12203 Necrostatin 2 S enantiomer Others
Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2
T9305 Necroptosis-IN-1 RIP kinase
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
T8468 CIL62 Caspase
CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].
T73521 Nec-3a
Nec-3a, an analogue of Necrostatin-3, acts as a RIP1 inhibitor with an inhibition concentration (IC50) of 0.44 μM. This compound successfully impedes the autophosphorylation activity within the RIP1 kinase domain.
TargetMol