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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7504 | Necrostatin 2 racemate | Necrostatin-2 racemate | RIP kinase |
Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1. | |||
T1847 | Necrostatin-1 | Nec-1,Necrostatin 1 | Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase |
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO. | |||
T25859 | Necrostatin-7 | Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7 | Apoptosis |
Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts. | |||
T37558 | Necrostatin-5 | Nec-5 | RIP kinase , Necroptosis |
Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM. | |||
T9095 | Necrostatin-34 | 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 | RIP kinase |
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain. | |||
T68520 | Cl-Necrostatin-1 | ||
Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase. It inhibits RIPK1 activity. | |||
T12203L | Necrostatin 2 | Others | |
Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. | |||
T12203 | Necrostatin 2 S enantiomer | Others | |
Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 | |||
T9305 | Necroptosis-IN-1 | RIP kinase | |
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1. | |||
T8468 | CIL62 | Caspase | |
CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1]. | |||
T73521 | Nec-3a | ||
Nec-3a, an analogue of Necrostatin-3, acts as a RIP1 inhibitor with an inhibition concentration (IC50) of 0.44 μM. This compound successfully impedes the autophosphorylation activity within the RIP1 kinase domain. |