mtc

S-MTC is a selective inhibitor of type I nitric oxide synthase.

MTC420 is a anti-tuberculosis agent with acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM).

Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.

S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.

NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid used as an endogenous nitrosation indicator in gas chromatography-thermal energy analysis (GC-TEA).

ETMTC is a inhibitor of inflammatory cell adhesion molecules (cams)

Acitazanolast (WP-871) is an anti-allergic drug candidate.

LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.

4-PivO-NMT chloride is an indole derivative-based regulator of the AMPK signaling pathway. It modulates neurogenesis or neurite outgrowth by influencing AMPK activity and holds potential for research in neurological disorders, pain, and inflammation.

Prolinomethyltetracycline is a hormone.

Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and protein. Through this action, Ezutromid increases muscle function in dystrophin-deficient MDX mice, a mouse model of muscular dystrophy.

5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].

5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog with exceptional safety and significant antisense activity, as demonstrated in studies [1] [2].

5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog and a modified antisense oligonucleotide [1].

5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].

5-Furan-2-yl-2'-O-methyl-5'-O-DMT-cytidine is a 5 modified pyrimidine nucleoside; 2'-O-Methyl nucleoside.

QMT-CBT is a near-infrared aggregation-induced emission compound. Upon activation of caspase1 (Cas1), QMT-CBT undergoes a CBT-Cys click reaction, forming a cyclic dimer known as QMT-Dimer (the first aggregate), which further assembles into nanoparticles (the second aggregate). This process turns on the AIE signal, enhancing imaging for Alzheimer's disease (AD).

RET-IN-25 (compound 6b) is an anticancer RET kinase inhibitor effective against medullary thyroid carcinoma (MTC), with half-maximal inhibitory concentrations (IC50s) of 3.6 μM at 3 days and 3.0 μM at 6 days in TT(C634R) MTC [1].

11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphoma through its parent compound, Tenacigenin B.