msi

MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B) with an IC50 of approximately 1 μM.

MSI-1701, an analogue of MSI-1436, enhances (MSI-1436) activity by increasing (pMEK) and (pERK) phosphorylation, thus promoting (PI3K/AKT) pathway signaling and inhibiting apoptosis in neuronal cells, which may contribute to its neuroprotective effects.

MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B) with an IC50 of approximately 1 μM.

Ro 08-2750 is a non-peptide, reversible nerve growth factor (NGF) inhibitor that binds to NGF with an IC50 of approximately 1 µM. It is also a selective MSI RNA-binding activity inhibitor, exhibiting an IC50 of 2.7 μM. Additionally, Ro 08-2750 selectively inhibits NGF binding to p75NTR over TRKA.

Squalamine is an aminosterol compound, with potent broad spectrum antiviral activity.

Squalamine lactate, an aminosterol compound discovered in the tissues of the dogfish shark, exhibits antimicrobial activity.

Pexiganan acetate (MSI 78) is a synthetic cationic peptide composed of 22 amino acids and demonstrates potent antibacterial activity. Pexiganan acetate is an analogue of magainin 2, which is a naturally occurring host defense peptide originally isolated from frog skin. The antibacterial action of Pexiganan acetate is thought to involve disruption of the integrity and permeability of the bacterial cell membrane or cell wall, leading to bacterial cell death.

Gimsilumab (MORAb-022) is a humanized monoclonal antibody targeting granulocyte macrophage colony-stimulating factor for the study of COVID-19-induced inflammation and hypoxemia.

Extensumside H is a useful organic compound for research related to life sciences. The catalog number is T125381 and the CAS number is 2079912-14-2.

Extensumside F is a useful organic compound for research related to life sciences. The catalog number is T125382 and the CAS number is 2079912-12-0.

Extensumside E is a useful organic compound for research related to life sciences. The catalog number is T125383 and the CAS number is 2079912-11-9.

Extensumside C is a useful organic compound for research related to life sciences. The catalog number is T125384 and the CAS number is 2079912-09-5.

Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.

Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.

Camsirubicin is a drug candidate of antineoplastic.

Trimetaphan camsilate is a drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor, is short-acting, and is given intravenously.

Camsirubicin, also known as GPX-150, MNPR-201, and CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis.

mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable activator of ERK 1/2 with an EC50 of 2.5-5 μM. It disrupts the interaction between the α and βγ subunits, facilitating α subunit dissociation without inducing nucleotide exchange [1].

mSIRK (L9A) is a cell-penetrating, N-myristoylated G protein-binding peptide (mSIRK) that includes a single point mutation where Leu9 is replaced with Ala. This modification prevents mSIRK (L9A) from enhancing ERK1/2 phosphorylation, making it useful as a control peptide.

c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).

c-Fms-IN-3 is a novel inhibitor of c-FMS, suitable for research on antirheumatic and anti-inflammatory diseases.

c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).

c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50 = 17 nM) and serves as an anti-inflammatory agent.

Kaolin (Bolus alba) is a clay dominated by minerals of the kaolinite family. Kaolin increased the sensitivity of this method for monitoring hemophilia therapy.