metastases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6451	Clodronic acid disodium salt	Loron,Clodronate Disodium,Lodronate	Others
	Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.		Others
T90596	Sivifene		Others
	Sivifene is a antitumor agent. Sivifene can be used for research on the treatment of cutaneous metastases from cancer.		Others
T6482	Efaproxiral Sodium	RSR13 sodium	Reactive Oxygen Species
	Efaproxiral Sodium (RSR13 sodium), a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.		Reactive Oxygen Species
T12205	Ned 19		Calcium Channel
	Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in mice.		Calcium Channel
T9869	N-[2-(diethylamino)ethyl]-2-iodobenzamide		Others
	N-[2-(diethylamino)ethyl]-2-iodobenzamide is a radiopharmaceutical for the scintigraphic detection of melanoma and metastases.		Others
T10397	ATN-161 trifluoroacetate salt	ATN-161 TFA salt	Integrin
	ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model.		Integrin
T22324	Ensartinib hydrochloride	Ensartinib dihydrochloride,X-396 dihydrochloride	Others , Trk receptor , c-Met/HGFR , ALK
	Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both...		Others , Trk receptor , c-Met/HGFR , ALK
TP1526L1	Fibronectin CS1 Peptide acetate		Others
	CS1 peptide is present within type III homology connecting segment (IIICS) as well as C-274 (cell-binding domain). Fibronectin CS1 Peptide lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in sp...		Others
T75643	Isoxanthohumol		HSV
	Isoxanthohumol is a prenylated flavonoid derived from hops and beer with antiproliferative activity against several human cancer cell lines.Isoxanthohumol inhibits the metastasis or invasion of lung metastases of tumor c...		HSV
T6739	Zoledronic Acid	CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa	Apoptosis , Rho , Autophagy
	Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalc...		Apoptosis , Rho , Autophagy
T39333	DOTA Zoledronate
	DOTA Zoledronate represents a novel, advanced compound utilized specifically in bone-targeted radionuclide therapy to diagnose bone metastases.
T10398	ATN-161		Others
	ATN-161 is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases in a murine model.		Others
T38181	C17 Lactosylceramide (d18:1/17:0)
	C17 Lactosylceramide is a naturally occurring sphingolipid that has been found in human brain metastases of lung adenocarcinomas but not in healthy brain tissue.
T68233	Kadsurenone
	Kadsurenone is a platelet-activating factor receptor antagonist from Chinese herbal plant, haifenteng. It is a useful and promising treatment strategy for breast cancer bone metastases by blocking the PAF/PTAFR signaling...
T11938	Macropa-NH2 hydrochloride		Others
	Macropa-NCS, conjugated to Anti-Human HER2 and the prostate-specific membrane antigen-targeting compound RPS-070, serves as a promising therapeutic radionuclide for soft-tissue metastases treatment. Its precursor, Macrop...		Others
T2610	BMS-599626	AC480	EGFR , MEK , HER , Src
	BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.		EGFR , MEK , HER , Src
T74607	KRAS G12D inhibitor 15
	KRAS G12D inhibitor 15 is a potent inhibitor specifically targeting the KRAS G12D mutation. It holds potential for research into numerous diseases or disorders, including cancer and its metastases[1].
T81522	Pendetide	GYK-DTPA
	Pendetide, a chelating agent, is conjugable with Indium (111In) Capromab to create Capromab Pendetide, an FDA-approved imaging agent used for detecting soft tissue metastases in prostate carcinoma [1].
TP2245	Endostatin (84-114)-NH2 (JKC367)		Others
	Endostatin is a potent inhibitor of primary tumor growth and endothelial cell proliferation and migration. Recombinant endostatin potently inhibited angiogenesis, maintains metastases at a low level, and suppressed tumor...		Others
T69714	Etanidazole
	Etanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This age...