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Search Results for "lung fibrosis"

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Compounds

Cat No.	Product Name
T0239	Lonidamine	Diclondazolic Acid,DICA,AF1890,氯尼达明	Hexokinase , Apoptosis , Mitochondrial Metabolism
	Lonidamine 是一种抗肿瘤药物，是己糖激酶、线粒体丙酮酸载体和质膜单羧酸转运蛋白抑制剂，同时也抑制线粒体复合物 II。		Hexokinase , Apoptosis , Mitochondrial Metabolism
T6S0105	Peiminine	Zhebeinone,Verticinone,Raddeanine,Fritillarine,贝母素乙	Others , Autophagy
	Peiminine 是浙贝母中的一种生物碱，具有抗炎症活性。		Others , Autophagy
T2S0690	Ecliptasaponin A	Echinocystic acid-3-o-glucoside,旱莲苷A,早莲苷 A	Others
	Ecliptasaponin A 是一种墨旱莲 (Eclipta prostrate) 中分离得到的五环三萜皂苷。其中墨旱莲是一种具有多效作用的滋补草药，如抗炎、保肝、抗氧化和免疫调节。		Others
T2663	GTS-21 dihydrochloride	DMXB-A,DMBX-anabaseine,GTS 21 dihydrochloride	AChR , 5-HT Receptor
	GTS 21 dihydrochloride 是一种选择性 α7 烟碱乙酰胆碱受体激动剂，具有抗炎和增强认知的活性。它也是一种拮抗剂，对人α4β2的 Ki 为20 nM，对5-HT3A 受体的 IC50为3.1 μM。		AChR , 5-HT Receptor
TN1936	Mogroside III-E	罗汉果皂苷ⅢE	TLR , TNF , IL Receptor
	Mogroside IIIe 是一种葫芦烷型化合物，从罗汉果中分离得到，可抑制 NO 的释放，具有抗肺纤维化作用。		TLR , TNF , IL Receptor
T5S0106	Peimisine	贝母辛,Ebeiensine	AChR , RAAS
	Peimisine 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。		AChR , RAAS
T6S1572	Sauchinone		NF-κB , p38 MAPK , ERK
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。		NF-κB , p38 MAPK , ERK
TP1016L	Aviptadil Acetate	Vasoactive Intestinal Peptide acetate salt,醋酸阿肽地尔,阿肽地尔	SARS-CoV , RAAS
	Aviptadil acetate 是模拟血管活性肠多肽类似物，具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。		SARS-CoV , RAAS
T16434	PAT-048		PDE
	PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibit...		PDE
T61581	LasR-IN-2
	LasR-IN-2, a compound that inhibits the activity of LasR, forms hydrogen bonding with the TRY-56 residue. It finds appli...
T64141	ATX inhibitor 11
	ATX inhibitor 11 是 ATX (autotaxin) 的有效抑制剂 (IC50: 2.7 nM)。ATX inhibitor 11 能够缓解小鼠纤维化模型中纤维化组织的严重程度，有效减少纤维化生物标志物 α-SMA 的沉积。...
T39719	Nrf2 activator-1	Nrf2 activator-1
	Nrf2 activator-1, a highly potent activator of NF-E2 related factor 2 (Nrf2), shows promising therapeutic potential for ...
T61612	ATX inhibitor 15
	ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX...
T69517	Bexotegrast HCl
	Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmon...
T69035	Camostat free base
	Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of ca...
TMPY-01110	Surfactant protein D/SFTPD Protein, Mouse, Recombinant (His Tag)
	Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type l...
TMPY-01634	Surfactant protein D/SFTPD Protein, Rhesus, Recombinant (His Tag)
	Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type l...
TMPY-01765	Surfactant protein D/SFTPD Protein, Human, Recombinant (His Tag)
	Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type l...
T63776	PDE1-IN-4
	PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂，能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 ...
TMPY-02783	Prostasin/PRSS8 Protein, Mouse, Recombinant (aa 30-289, His Tag)
	Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays impo...