kinetic

Sulfamonomethoxine is a long-acting sulfonamide antibacterial agent, blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.

LC kinetic stabilizer-1 is a potent, selective kinetic stabilizer for amyloidogenic immunoglobulin light chains, demonstrating EC50 values of 140 nM for WIL-FL* and 74.1 nM for WIL-FL*T46L/F49Y, respectively. Notably, WIL-FL represents an amyloidogenic FL LC dimer.

LC Kinetic Stabilizer-2 is a powerful stabilizer for amyloidogenic immunoglobulin light chains (LC), demonstrating significant efficacy with an EC50 of 24 nM.

Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II), an insect adipokinetic hormone (AKH), elevates fat body cAMP levels in vitro. These hormones (AKHs) regulate the mobilization of carbohydrates and lipids from fat body reserves for flight by activating AKH receptor(s) that stimulate cAMP production and glycogen phosphorylase through the stimulatory guanine nucleotide-binding protein (Gs) [1] [3].

Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I), an insect adipokinetic hormone (AKH), increases fat body cAMP levels in vitro and regulates the mobilization of carbohydrates and lipids from fat body stores for flight, through AKH receptor(s)' association with cAMP production and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) [1] [3].

Prokineticin 2 Isoform 2 (human), a hypothalamic neuropeptide, regulates thermoregulation and energy metabolism while decreasing food intake in rodents. This isoform is implicated in the study of metabolic syndrome (MetS), obesity, and hyperglycemia [1].

Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta), a peptide shared by diverse insects, elicits a potent adipokinetic/hypertrehalosemic response but lacks the function to mobilize glycogen and maintains an inadequate glycogen reserve in the fat body for effective utilization [1].

Adipokinetic hormone Gryllus bimaculatus (Grybi-AKH), an adipokinetic hormone, mobilizes lipids and carbohydrates from the insect fat body, regulating energy homeostasis. It also enhances the locomotor activity of the two-spotted cricket and has potential applications in human medical studies for body weight regulation, weight loss induction, and alleviation of glycogen storage disorders [1] [2] [3].

Adipokinetic Hormone (AKH) (24-32), locust (TFA), is a neurohormone extracted from the corpora cardiaca of locusts that regulates lipid utilization during flight [1].

Adipokinetic Hormone (AKH) (24-32), locust, is a peptide hormone isolated from locusts.

TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).

Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.

Itopride hydrochloride (Ganaton) is an AChE and D2DR inhibitor.

Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis.

Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

An antibiotic produced by Streptomyces fradiae.

Sulfachloropyrazine sodium(Sulfachloropyrazine) is an antiprotozoal,with antibacterial and anticoccidial effects

Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.

Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes

Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).

Tiapride is a selective blocker of D2/3 dopamine receptors in the brain. It is used in the therapy of various psychiatric and neurological disorders containing dyskinesia, negative symptoms of psychosis, alcohol withdrawal syndrome, and aggression and agitation in the elderly.

Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).

NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.

GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties.